2021 Fiscal Year Final Research Report

Development of mice model for elucidating the mechanism of healthy life expectancy extension

Research Project

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Project/Area Number	20K20310
Project/Area Number (Other)	17H06284 (2017-2019)
Research Category	Grant-in-Aid for Challenging Research (Pioneering)
Allocation Type	Multi-year Fund (2020) Single-year Grants (2017-2019)
Research Field	Health science and related fields
Research Institution	Hiroshima University
Principal Investigator	Kamiya Kenji 広島大学, 医療政策室, 特任教授 (60116564)
Co-Investigator(Kenkyū-buntansha)	河合秀彦広島大学, 医系科学研究科(薬), 准教授 (30379846) 笹谷めぐみ (豊島めぐみ) 広島大学, 原爆放射線医科学研究所, 准教授 (80423052) 林田耕臣広島大学, 原爆放射線医科学研究所, 助教 (10882061) 神代紗央理広島大学, 原爆放射線医科学研究所, 助教 (60882058)
Project Period (FY)	2017-06-30 – 2022-03-31
Keywords	放射線発がん / 老化 / SASP
Outline of Final Research Achievements	To extend healthy life expectancy are now urgent issues as the super-aged society continues to develop in Japan. Our previous studies have revealed that chronic radiation exposure could accelerate aging process efficiently in vitro and in vivo. Furthermore, we have developed the mouse model susceptible for radiation-induced carcinogenesis at low doses and low dose rates. In this study, we generated the novel mouse model to elucidate the mechanism of radiation induced senescence and aging involved in the senescence-associated secretory phenotype (SASP). Furthermore, we developed the mouse model for elucidation the role of DNA repair system in chronic radiation-induced senescence. The elucidation of the mechanism of senescence induction by chronic irradiation using our developed mouse models is helped to conceptualize aging research for extending healthy life extension. Our research might be expected to contribute to the progress of the research field of healthy life extension.
Free Research Field	放射線影響研究分野
Academic Significance and Societal Importance of the Research Achievements	本研究課題である老化解析のためのモデルマウスの開発は、老化研究を飛躍的に発展させるブレークスルーとなり、世界が直面する超高齢化社会に対して多大な貢献が期待できる。さらに、本研究で開発したモデルマウスを用いた低線量率放射線被ばくによる発がんメカニズムの解明は、持続的な放射線被ばくでの健康影響評価のための科学的知見を提供できる可能性があり、社会的意義を有する。