A Novel Mechanism of Genetic Mutation Independent Metal Tolerance in a Multi-Hierarchical Terrestrial Organism Population Using High Precision XAFS

2022 Fiscal Year Annual Research Report

• Project/Area Number: 20K20633
• Research Institution: Hokkaido University
• Principal Investigator: 中山 翔太 北海道大学, 獣医学研究院, 准教授 (90647629)
• Co-Investigator(Kenkyū-buntansha): 藤森 崇 龍谷大学, 先端理工学部, 准教授 (20583248) ; 中田 北斗 北海道大学, 獣医学研究院, 博士研究員 (60815273) [Withdrawn] ; 銅谷 理緒 北海道大学, 獣医学研究院, 学術研究員 (00934415)
• Project Period (FY): 2020-07-30 – 2023-03-31
• Keywords: 金属耐性機構 / 動物種差 / XAFS解析 / エピジェネティクス解析 / 毒性発現

Outline of Annual Research Achievements

高濃度の鉛に暴露されても毒性影響が顕在化しない陸生動物におけるメカニズム解明のため、鉛の化学形態解析に注目して大型放射光施設のXAFS解析を環境毒性学分野において応用した。凍結乾燥による試料均一性の増大や鉛濃度の濃縮により、測定制約のあった実験室内投与実験ではない「フィールド由来生物試料のXANESスペクトル」の測定に成功した。野生のラット、トカゲ、ニワトリ、イヌにおける肝臓、腎臓、心臓、脳、肺、脾臓、筋肉、胃・小腸・大腸の内容物、および糞便における鉛形態の違いや、消化器系や体内へ吸収された際の鉛化学形態の変化に関する精緻な知見を初めて得た。トカゲ臓器の鉛のXAFSにおいては肝臓のスペクトルは個体間で差がなく前述のチオール基と結合した鉛と類似したスペクトルを示した。これらは肝臓が重金属の解毒／排出機構においてグルタチオン等の分子を介して重要な役割を果たすことを反映していると考えられた。一方で個体ごとに臓器間でスペクトルを比較すると、肝臓、肺、胃内容物の間で大きな差が見られない個体グループと、肺で特徴的なスペクトルを示す個体グループに分かれた。これらの個体について硫黄のXAFSにも着目すると、肝臓と肺の鉛スペクトルが異なった個体どうしでは肺の硫黄スペクトルが類似しており、またこれらのピーク位置は土壌のものと一致した。このピーク位置は環境中に多く存在する硫酸化合物のものとも一致しており、鉛でも他の臓器と異なるスペクトルが得られた傾向と合わせて、肺では土壌の吸入の影響が大きいことを反映していると考えられた。スペクトルに結合元素や酸化状態ごとに違いが現れやすい硫黄にも着目して解析を行うことで、微細な構造に着目する必要のある鉛のスペクトル解析から得られた暴露経路の推定を補強できる一例であり、この手法は他の動物種や地域の研究でも応用可能である。

Research Products

• [Int'l Joint Research] ザンビア大学/ザンビア保健省/ザンビア鉱山省(ザンビア)
  • Country Name: ZAMBIA
  • Counterpart Institution: ザンビア大学/ザンビア保健省/ザンビア鉱山省
  • # of Other Institutions: 3
• [Int'l Joint Research] ナミビア大学(ナミビア)
  • Country Name: NAMIBIA
  • Counterpart Institution: ナミビア大学
• [Int'l Joint Research] ジンバブエ大学(ジンバブエ)
  • Country Name: ZIMBABWE
  • Counterpart Institution: ジンバブエ大学
• [Int'l Joint Research] ボツワナ大学(ボツワナ)
  • Country Name: BOTSWANA
  • Counterpart Institution: ボツワナ大学
• [Journal Article] Immobilization of Pb and Zn leached from mining residue materials in Kabwe, Zambia: Performance of calcined dolomite in column experiments (2023)
  • Author(s): Mufalo Walubita、Tangviroon Pawit、Arima Takahiko、Igarashi Toshifumi、Ito Mayumi、Sato Tsutomu、Noto Kenta、Kawashima Takeshi、Nyambe Imasiku、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Journal of Geochemical Exploration Volume: 249 Pages: 107209～107209
  • DOI: 10.1016/j.gexplo.2023.107209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Social cost of mining-related lead (Pb) pollution in Kabwe, Zambia, and potential remediation measures (2023)
  • Author(s): Yamada Daichi、Hiwatari Masato、Narita Daiju、Hangoma Peter、Chitah Bona、Nakata Hokuto、Nakayama Shouta M.M.、Yabe John、Ito Mayumi、Igarashi Toshifumi、Ishizuka Mayumi、Zyambo Golden
  • Journal Title: Science of The Total Environment Volume: 865 Pages: 161281～161281
  • DOI: 10.1016/j.scitotenv.2022.161281
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accumulation of Metals in the Environment and Grazing Livestock near A Mongolian Mining Area (2022)
  • Author(s): Bataa Bayartogtokh、Motohira Kodai、Dugar Delgermurun、Sainnokhoi Tsend-Ayush、Gendenpil Lkhamjav、Sainnokhoi Tserenchimed、Pelden Bolormaa、Yohannes Yared Beyene、Ganzorig Sumiya、Nakayama Shouta M. M.、Ishizuka Mayumi、Ikenaka Yoshinori
  • Journal Title: Toxics Volume: 10 Pages: 773～773
  • DOI: 10.3390/toxics10120773
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimation of the reference lead (Pb) concentration levels affecting immune cells in the blood of Black-headed Gulls (Chroicocephalus ridibundus, Laridae) (2022)
  • Author(s): Ushine Nana、Kurata Osamu、Tanaka Yoshikazu、Nakayama Shouta M.M、Ishizuka Mayumi、Kato Takuya、Hayama Shin-Ichi
  • Journal Title: Avian Conservation and Ecology Volume: 17 Pages: -
  • DOI: 10.5751/ACE-02336-170240
  • Peer Reviewed / Open Access
• [Journal Article] Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb) (2022)
  • Author(s): Yohannes Yared Beyene、Nakayama Shouta M.M.、Yabe John、Toyomaki Haruya、Kataba Andrew、Nakata Hokuto、Muzandu Kaampwe、Miyashita Chihiro、Ikenaka Yoshinori、Choongo Kennedy、Ishizuka Mayumi
  • Journal Title: Epigenetics Volume: 17 Pages: 2377～2388
  • DOI: 10.1080/15592294.2022.2123924
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interdisciplinary approach to addressing lead pollution caused by mining activity in Kabwe, The Republic of Zambia (2022)
  • Author(s): NAKATA Hokuto、NAKAYAMA Shouta M. M.、YABE John、MUZANDU Kaampwe、KATABA Andrew、IKENAKA Yoshinori、ISHIZUKA Mayumi
  • Journal Title: Environmental Monitoring and Contaminants Research Volume: 2 Pages: 94～111
  • DOI: 10.5985/emcr.20220004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague?Dawley rats? (2022)
  • Author(s): Nakata Hokuto、Nakayama Shouta M.M.、Kataba Andrew、Toyomaki Haruya、Doya Rio、Beyene Yohannes Yared、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: Journal of Functional Foods Volume: 97 Pages: 105242～105242
  • DOI: 10.1016/j.jff.2022.105242
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Narrative review of lead poisoning in humans caused by industrial activities and measures compatible with sustainable industrial activities in Republic of Zambia (2022)
  • Author(s): Nakata Hokuto、Nakayama Shouta M.M.、Yabe John、Muzandu Kaampwe、Kataba Andrew、Ikeda-Araki Atsuko、Drisse Marie-Noel Brune、Onyon Lesley Jayne、Gorman Julia、Kritika Poudel、Fukunaga Hisanori、Ikenaka Yoshinori、Kishi Reiko、Ishizuka Mayumi
  • Journal Title: Science of The Total Environment Volume: 850 Pages: 157833～157833
  • DOI: 10.1016/j.scitotenv.2022.157833
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Behavior and toxic effects of Pb in a waterfowl model with oral exposure to Pb shots: Investigating Pb exposure in wild birds (2022)
  • Author(s): Sato Hiroshi、Ishii Chihiro、Nakayama Shouta M.M.、Ichise Takahiro、Saito Keisuke、Watanabe Yukiko、Ogasawara Kohei、Torimoto Ryota、Kobayashi Atsushi、Kimura Takashi、Nakamura Yukiko、Yamagishi Junya、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: Environmental Pollution Volume: 308 Pages: 119580～119580
  • DOI: 10.1016/j.envpol.2022.119580
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impacts of Surface Water on Windborne Lead Dispersion from the Zinc Plant Leach Residue in Kabwe, Zambia (2022)
  • Author(s): Nakamura Shinsaku、Igarashi Toshifumi、Uchida Yoshitaka、Ito Mayumi、Hirose Kazuyo、Sato Tsutomu、Mufalo Walubita、Chirwa Meki、Nyambe Imasiku、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Minerals Volume: 12 Pages: 535～535
  • DOI: 10.3390/min12050535
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human Health Risk Assessment from Lead Exposure through Consumption of Raw Cow Milk from Free-Range Cattle Reared in the Vicinity of a Lead?Zinc Mine in Kabwe (2022)
  • Author(s): Zyambo Golden、Yabe John、Muzandu Kaampwe、M’kandawire Ethel、Choongo Kennedy、Kataba Andrew、Chawinga Kenneth、Liazambi Allan、Nakayama Shouta M. M、Nakata Hokuto、Ishizuka Mayumi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19 Pages: 4757～4757
  • DOI: 10.3390/ijerph19084757
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Alkaline Leaching and Concurrent Cementation of Dissolved Pb and Zn from Zinc Plant Leach Residues (2022)
  • Author(s): Silwamba Marthias、Ito Mayumi、Hiroyoshi Naoki、Tabelin Carlito Baltazar、Hashizume Ryota、Fukushima Tomoki、Park Ilhwan、Jeon Sanghee、Igarashi Toshifumi、Sato Tsutomu、Nyambe Imasiku、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Minerals Volume: 12 Pages: 393～393
  • DOI: 10.3390/min12040393
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Geochemical identification of particulate lead pollution in shallow groundwater in inhabited areas in Kabwe, Zambia (2022)
  • Author(s): Toyoda Kazuhiro、Nakano Shota、Tanaka Shunitz、Banda Kawawa、Nyambe Imasiku A.、Ishikawa Tsuyoshi、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Applied Geochemistry Volume: 139 Pages: 105215～105215
  • DOI: 10.1016/j.apgeochem.2022.105215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study (2022)
  • Author(s): Nakata Hokuto、Eguchi Akifumi、Nakayama Shouta M. M.、Yabe John、Muzandu Kaampwe、Ikenaka Yoshinori、Mori Chisato、Ishizuka Mayumi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19 Pages: 541～541
  • DOI: 10.3390/ijerph19010541
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Geospatial approach to investigate spatial clustering and hotspots of blood lead levels in children within Kabwe, Zambia (2022)
  • Author(s): Moonga Given、Chisola Moses N.、Berger Ursula、Nowak Dennis、Yabe John、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi、Bose-O'Reilly Stephan
  • Journal Title: Environmental Research Volume: 207 Pages: 112646～112646
  • DOI: 10.1016/j.envres.2021.112646
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Environmental, animal and human health impacts of lead and other heavy metals arising from unsustainable mining activities in Kabwe, Zambia: a One Health Approach (2023)
  • Author(s): John Yabe, Shouta MM Nakayama, Yared B Yohannes, Hokuto Nakata, Haruya Toyomaki, Kaampwe Muzandu, Andrew Kataba, Golden Zyambo, Nosiku Sipilanyambe Munyinda, Tiza Mufune, Allan Liazambi, Kenneth Chawinga, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka
  • Organizer: 6th International Chemical Hazard Symposium ＆ 6th Symposium of Japan Society for Environmental Chemistry, Hokkaido-Tohoku Branch
  • Int'l Joint Research / Invited
• [Presentation] Investigating Mechanisms of High Metal Accumulation in Wild Lizards in Zambia by XAFS Analysis of Lead and Sulfur Chemical Species (2023)
  • Author(s): Rio Doya, Shouta M.M. Nakayama, Takashi Fujimori, Kenji Shiota, Hokuto Nakata, Golden Zyambo, Nyein Chan Soe, Andrew Kataba, Kaampwe Muzandu, John Yabe, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 6th International Chemical Hazard Symposium ＆ 6th Symposium of Japan Society for Environmental Chemistry, Hokkaido-Tohoku Branch
  • Int'l Joint Research
• [Presentation] Distribution of lead in organs of stray dogs from Kabwe, Zambia (2023)
  • Author(s): Nyein Chan Soe, Andrew Kataba, Yared B. Yohannes, Madalitso Tembo, John Yabe, Kenneth Chawinga, Golden Zyambo, Kaampwe Muzandu, Yoshinori Ikenaka1, Mayumi Ishizuka, Shouta M.M. Nakayama
  • Organizer: 6th International Chemical Hazard Symposium ＆ 6th Symposium of Japan Society for Environmental Chemistry, Hokkaido-Tohoku Branch
  • Int'l Joint Research
• [Presentation] Impact of Lead on Human Health: a Kabwe, Zambia perspective (2023)
  • Author(s): Yabe J, Nakayama S, Yohannes YB, Nakata H, Toyomaki H, Muzandu K, Kataba A, Zyambo G, Moonga G, Munyinda NS, Mufune T, Liazambi A, Chawinga K, Sakala D, Ikenaka Y, Choongo K, Ishizuka M
  • Organizer: BirdLife South Africa, Lead Advocacy Workshop for the Conservation of Southern African Vultures
  • Int'l Joint Research / Invited
• [Presentation] Global and Gene-Specific Methylation in Lead-Exposed Children in Kabwe, Zambia (2023)
  • Author(s): Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Kennedy Choongo, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: SOT 62nd Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] ザンビアにおける鉛汚染とヒト・動物への健康影響 (2023)
  • Author(s): 中山翔太、石塚真由美
  • Organizer: 日本薬学会第143年会
  • Invited
• [Presentation] Immobilization of lead in soil by chicken manure and its efficacy on a mouse model (2022)
  • Author(s): Nyein Chan Soe, Takamitsu Ohigashi, Hokuto Nakata, Chikae Tatsumi, Yoshitaka Uchida, Walubita Mufalo, Mayumi Ito, Tsutomu Sato, Toshifumi Igarashi, Yared B. Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta M.M. Nakayama
  • Organizer: Japan Geoscience Union (JpGU) Meeting 2022～セッションM-ZZ51：環境汚染・環境毒性と生物～
• [Presentation] Land-use Based Mapping of Lead Exposure Risk around a Former Mining Site in Zambia, using Lizard Biomonitoring Data (2022)
  • Author(s): 銅谷 理緒、中山 翔太、中田 北斗、Yabe John、Muzandu Kaampwe、池中 良徳、石塚 真由美
  • Organizer: Japan Geoscience Union (JpGU) Meeting 2022～セッションM-ZZ51：環境汚染・環境毒性と生物～
• [Presentation] ザンビア・カブエ地区における高濃度鉛汚染を示した犬のゲノムワイドなDNAメチル化解析 (2022)
  • Author(s): 山﨑 淳平、豊巻 治也、中山 翔太、Yabe John、Muzandu Kaampwe、Jelinek Jaroslav、横山 晶子、池中 良徳、滝口 満喜、石塚 真由美
  • Organizer: Japan Geoscience Union (JpGU) Meeting 2022～セッションM-ZZ51：環境汚染・環境毒性と生物～
• [Presentation] Lead Poisoning Among Residents of the Zambian Settlement of KABWE, Particularly Among Children (2022)
  • Author(s): YARED Beyene Yohannes, Nakayama S.M.M, Yabe J, Haruya T, Kataba A, Muzandu K, Nakata H, Ikenaka Y, Choongo K, Ishizuka M
  • Organizer: Japan Geoscience Union (JpGU) Meeting 2022～セッションM-ZZ51：環境汚染・環境毒性と生物～
• [Presentation] 鉛と硫黄の化学形態から野生トカゲの生体内重金属類高濃度要因を探る-ザンビア共和国鉱床地域での研究例- (2022)
  • Author(s): 銅谷 理緒，中山 翔太，藤森 崇，塩田 憲司，中田 北斗，Golden Zyambo，Nyein Chan Soe，Andrew Kataba，Kaampwe Muzandu，John Yabe，池中 良徳，石塚 真由美
  • Organizer: 環境化学物質3学会合同大会
• [Presentation] Wild Lizards as a Target of Heavy Metal Biomonitoring Focusing on Land Use Patterns; Example from a Former Mining Site in Zambia (2022)
  • Author(s): Rio Doya, Shouta M.M. Nakayama, Hokuto Nakata, Mitsuki Kondo, Golden Zyambo, John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, and Mayumi Ishizuka
  • Organizer: 第49回日本毒性学会学術年会
• [Presentation] In vivo accumulation of different lead species in mice under environmentally relevance circumstance (2022)
  • Author(s): Nyein Chan Soe, Takamitsu Ohigashi, Hokuto Nakata, Chikae Tatsumi, Yoshitaka Uchida, Walubita Mufalo, Mayumi Ito, Tsutomu Sato, Toshifumi Igarashi, Yared B. Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta M.M. Nakayama
  • Organizer: 第49回日本毒性学会学術年会
• [Presentation] Lead and Heavy Metals arising from unsustainable Mining activities in Kabwe, Zambia (2022)
  • Author(s): Yabe J, Nakayama S, Nakata H, Yohannes YB, Toyomaki H, Muzandu K, Moonga G, Kataba A, Zyambo G, Munyinda NS, Mufune T, Liazambi A, Choongo K, Ishizuka M.
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] The impact of elevated blood lead levels in children on maternal health-related quality of life (2022)
  • Author(s): Nosiku Munyinda, Sandra Shanungu, Given Moonga, Doreen Sakala, Lweendo Hachamba, Kennedy Choongo, Harukazu Tohyama, Wakako Fujita, John Yabe, Shouta MM Nakayama, Mayumi Ishizuka
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] Lead Exposure and its Epi-(Genetic) Effects on Children in Kabwe, Zambia (2022)
  • Author(s): YARED Beyene Yohannes, Nakayama S.M.M, Yabe J, Haruya T, Kataba A, Muzandu K, Nakata H, Ikenaka Y, Choongo K, Ishizuka M
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] Genome-wide analysis of DNA methylation in canine brain from Kabwe, Zambia (2022)
  • Author(s): Nyein Chan Soe, Jumpei Yamazaki, John Yabe, Kaampwe Muzandu, Andrew Kataba, Golden Zyambo, Hokuto Nakata, Kenneth Chawiga, Allan Liazambi, Yared B. Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta M.M. Nakayama
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] Land use and Dispersion Pattern Affect Exposure Levels of Lizard to Lead in Kabwe (2022)
  • Author(s): Rio Doya, Shouta M.M. Nakayama, Hokuto Nakata, Golden Zyambo, John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] Analysis of Lead Accumulation and Expression of Genes related to Glucose Metabolism in Wild Rats in High and Low Lead Contaminated Areas in Zambia. (2022)
  • Author(s): Seigo Ishihara, Hokuto Nakata, John Yabe, Andrew Kataba, Kaampwe Muzandu, Golden Zyambo, Kodai Motohira, Yared Beyene Yohannes, Rio Doya, Mitsuki Kondo, Takahiro Ichise, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta Nakayama
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] Environmentally relevant lead levels induce neuromuscular, cardiovascular and oxidative stress systems derangements in zebrafish embryos. (2022)
  • Author(s): Andrew Kataba, Tarryn L. Botha, Shouta M.M Nakayama, Yared B. Yohannes, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] Evaluation of lead exposure in cow milk for risk assessment in Kabwe, Zambia (2022)
  • Author(s): Golden Zyambo, John Yabe, Kaampwe Muzandu, Ethel M’kandawire, Kennedy Choongo, Andrew Kataba, Kenneth Chawinga, Allan Liazambi, Shouta M. M. Nakayama, Hokuto Nakata, Mayumi Ishizuka
  • Organizer: International Forum: Interdisciplinary Challenge Mine and Environment
  • Int'l Joint Research
• [Presentation] Zambiaの鉛高濃度汚染地域と低濃度汚染地域における野生ラットの鉛蓄積量及び糖代謝関連遺伝子発現量の解析 (2022)
  • Author(s): 石原清伍,中田北斗, John Yabe, Andrew Kataba, Kaampwe Muzandu, Golden Zyambo, 本平航大, 銅谷理緒, Yared Yohannes, 近藤充希, 一瀬貴大, 池中良徳, 石塚真由美, 中山翔太
  • Organizer: 第165回日本獣医学会学術集会
• [Presentation] Effect on lead- induced oxidative stress, inflammation and cell apoptosis in mice by adding chicken manure in lead spiked soil (2022)
  • Author(s): Nyein Chan Soe, Takamitsu Ohigashi, Hokuto Nakata, Chikae Tatsumi, Yoshitaka Uchida, Yared B. Yohannes, Kodai Motohira, Takahiro Ichise, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta M.M. Nakayama
  • Organizer: SaSSOH 2022
  • Int'l Joint Research
• [Presentation] Land use and Dispersion Pattern Affect Exposure Levels to Lead in Wild Lizards (2022)
  • Author(s): Rio Doya, Shouta M.M. Nakayama, Hokuto Nakata, Golden Zyambo, John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 第8回北大部局横断シンポジウム
• [Presentation] アフリカにおける人と動物の環境金属汚染の解明と対策法の開発 (2022)
  • Author(s): 中山翔太
  • Organizer: 第21回日本農学進歩賞受賞講演
  • Invited
• [Presentation] Metal accumulation and toxicity evaluation in terrestrial environment using wild rodents and lizards (2022)
  • Author(s): Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Rio Doya, Kaampwe Muzandu, Akifumi Eguchi, Yared Yohannes, Yoshinori Ikenaka, Golden Zyambo, Andrew Kataba, Mayumi Ishizuka
  • Organizer: SETAC North America 43rd Annual Meeting
  • Int'l Joint Research
• [Remarks] 北海道大学大学院獣医学研究院毒性学教室
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Funded Workshop] International Forum: Interdisciplinary Challenge Mine and Environment (2022)