2021 Fiscal Year Final Research Report
Fabrication of Conductive Metallic Micro needles by Superplastic Deformation and Its Fracture for Medical and Biochemical Applications
| Project/Area Number |
20K21074
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 26:Materials engineering and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Keywords | ダイレス引抜き / 超塑性変形 / 破壊 / 金属マイクロニードル / ライフセルアトラス |
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| Outline of Final Research Achievements |
In this study, an novel manufacturing process of superplastic deformation and fracture to fabricate tubuler microneedles of metallic materials was proposed. The outer diameter distribution can be controlled by varying the speed ratio to various desired taper shapes, and ultrafine metal tubuler microneedles with a tip diameter of approximately 50 μm were successfully fabricated by using fracture phenomenon. These results indicate that we have succeeded in developing an innovative fabrication method to realize metal tubuler microneedles with ultra-fine tip diameter by inducing large deformation of the superplastic material and finally forcing it to fracture.
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| Free Research Field |
塑性加工
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| Academic Significance and Societal Importance of the Research Achievements |
新しい金属マイクロニードルを使うことで，1個の細胞のメカニズム解析による細胞が変化する瞬間を効率的に顕微鏡下にて瞬間的に拾い上げることができ，今後，疾患など体内で生じるメカニズムを調べる上で，この手法が主流となりえる．またライフサイエンス研究を推進させることができる．また本研究のアイデアはこれまでの塑性加工の常識を覆し，あえて変形の先にある破壊現象を制御することによって新たな塑性加工の価値を創出することにあり，学術的な研究面としても非常にこれまでにない発想に基づいており，従来の変形加工技術の概念を覆す可能性は十分に備えているといえる．
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