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2021 Fiscal Year Final Research Report

Development of rotaxane-based supramolecular mechanophores utilizing FRET

Research Project

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Project/Area Number 20K21215
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 35:Polymers, organic materials, and related fields
Research InstitutionTokyo Institute of Technology

Principal Investigator

Sagara Yoshimitsu  東京工業大学, 物質理工学院, 准教授 (60767292)

Project Period (FY) 2020-07-30 – 2022-03-31
Keywords超分子メカノフォア / FRET / ロタキサン / 機械的刺激応答性発光材料 / 蛍光
Outline of Final Research Achievements

Recently, molecular structures called "mechanophores," which show various outputs at the single molecule level in response to mechanical stimuli, have been studied. While most mechanophores reported so far require covalent bond cleavage, we are developing "supramolecular mechanophores" that change their fluorescent properties without covalent bond cleavage. In mechanophores based on the motif of rotaxane, high planarity has been required for the fluorophore. In this study, to overcome this problem, we have shown that an energy transfer mechanism can be introduced into rotaxane-based supramolecular mechanophores.

Free Research Field

光機能性超分子

Academic Significance and Societal Importance of the Research Achievements

ロタキサンをモチーフとした超分子メカノフォアの開発においては、使用する蛍光団には平面性が高いことが求められ、その結果、蛍光団の選択肢を狭めていた。本研究においてエネルギー移動機構を活用できることが明らかとなったため、今後嵩高い構造を持つ蛍光団を超分子メカノフォアに組み込むことができるようになる。また、今回ヒドロゲル中で超分子メカノフォアが機能することが明らかとなり、ポリウレタンのような疎水性の高い環境のみならず、親水的な環境でも超分子メカノフォアが機能することが明らかとなった。以上より本研究課題の当初の目的以上に超分子メカノフォアの研究対象・応用先を拡張できたと言える。

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Published: 2023-01-30  

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