2023 Fiscal Year Final Research Report
Development of next-generation vaccine strains against neosporosis and their application for vector based on protozoan parasite
| Project/Area Number |
20K21359
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 42:Veterinary medical science, animal science, and related fields
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邉 謙一 帯広畜産大学, 畜産学部, 准教授 (10761702)
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| Project Period (FY) |
2020-07-30 – 2024-03-31
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| Keywords | 原虫 / ネオスポラ / ワクチン / ベクター |
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| Outline of Final Research Achievements |
Although the progress in immunology has led to the development of various vaccines against viruses and bacteria, the development of vaccines against protozoan diseases has been extremely difficult. Recent advances in gene editing technology have facilitated the introduction and disruption of genes in various organisms, and in the field of parasite research, it has become possible to reduce the virulence of the parasites by gene disruption. In this study, based on our gene editing technology, we generated a next-generation Neospora vaccine strain that lacks the ability to transmit infection, and confirmed its protective effect against infection with Neospora and its therapeutic effect against cancer. It is expected that the attenuated strain will be used to control intractable parasitic diseases and to develop a cancer vaccine.
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| Free Research Field |
感染免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
近年、様々なサブユニットワクチン開発が行われ、ウイルスベクターを中心にヒトでの臨床開発が進められている。しかしながら、ウイルスベクターの安全性が懸念されている。一方、ネオスポラはヒトでの免疫誘導能は保持するが病原性・感染性は極めて低く、細胞ゲノムへの組込みリスクや体外排出は認められない。従って、ネオスポラのベクター化の試みが癌などの難治性疾患の制圧戦略に向けた新たな研究分野の創出へ寄与する可能性が期待される。
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