The mechanism to maintain hematopoietic homeostasis through B lymphocytes

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21518
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 49:Pathology, infection/immunology, and related fields
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Kanayama Masashi 東京医科歯科大学, 難治疾患研究所, 助教 (80811223)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: B細胞 / 造血 / 感染症

Outline of Final Research Achievements

Innate immune cells contribute to host protection and inflammation induced by infection. Since the number of innate immune cells such as neutrophils and monocytes is greatly affected by hematopoisis, understanding the mechanism of infection-induced hematopoiesis may serve to control the diseases. In infection-driven hematopoiesis, the generation of lymphocytes is decreased, although the generation of innate immune cells is enhanced. Therefore, the role of lymphocytes in infection-driven hematopoiesis has not been fully elucidated. In this study, we examined the impact of B lymphocytes in the maintenance of hematopoietic system and hematopoietic responses under infection.

Free Research Field

免疫学、血液学

Academic Significance and Societal Importance of the Research Achievements

本研究ではB細胞が感染時の造血系の維持や造血応答に及ぼす影響を明らかにした。これは新たな造血応答機構の発見であり、将来的に造血系を標的とした感染症や炎症の治療法開発に繋がると期待できる。（研究内容の詳細は論文公表まで差し控える。）