2021 Fiscal Year Final Research Report
Re-understanding of Systemic Metabolism through Skin-mediated Thermal Regulation
Project/Area Number |
20K21620
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
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Research Institution | National Center for Global Health and Medicine |
Principal Investigator |
Ueki Kohjiro 国立研究開発法人国立国際医療研究センター, その他部局等, 糖尿病研究センター長 (00396714)
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Co-Investigator(Kenkyū-buntansha) |
粟澤 元晴 国立研究開発法人国立国際医療研究センター, その他部局等, 糖尿病研究センター 分子糖尿病医学研究部 統合生理学研究室長 (90466764)
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Project Period (FY) |
2020-07-30 – 2022-03-31
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Keywords | 皮膚 / シングルセル解析 / 糖代謝 / 肥満 / 熱放散 |
Outline of Final Research Achievements |
When prostacyclin analogs were topically applied to the skin of the mouse tail, an increase in skin temperature of the tail was observed by thermography, establishing a mouse model of enhanced heat dissipation. Interestingly, there was a significant decrease in blood glucose, which was associated with a significant change in expression of genes related to liver gluconeogenesis. These changes were very similar to those seen during cold stimulation.To further investigate the possibility that the alteration of skin physiology occurs in obesity and plays an active role in its pathophysiology, single-cell RNA sequencing analysis of mouse skin was conducted. In an obese mouse model, alterations of gene expressions in various cell clusters within the skin were observed, some of which were molecules that are involved in inflammation and systemic heat production.
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Free Research Field |
代謝学
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Academic Significance and Societal Importance of the Research Achievements |
今回の研究を通じ、肥満状態においては皮膚の分子生物学的性質変化が生じうること、さらにまたそうした皮膚の機能変化が、実際に全身の代謝に対して影響を持ちうることを初めて示した。これまでの代謝研究では皮膚は糖尿病の合併症臓器として捉えられることが常であったが、本研究に基づき皮膚が全身の代謝制御に積極的な役割を果たしている可能性が提示され、今後の皮膚代謝学というべき分野として、発展的研究を進めるための根拠が得られた。
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