2022 Fiscal Year Final Research Report
An Epidemiological Study of the Role of Intestinal Microbiota Measurements in Elucidating the Brain-Gut-Adipose Axis
| Project/Area Number |
20K21719
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Ohira Tetsuya 福島県立医科大学, 医学部, 教授 (50448031)
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| Co-Investigator(Kenkyū-buntansha) |
木山 昌彦 公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病予防健診部・健康開発, その他部局等, その他 (10450925)
今野 弘規 大阪大学, 大学院医学系研究科, 招へい教授 (90450923)
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| Project Period (FY) |
2020-07-30 – 2023-03-31
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| Keywords | 腸内細菌叢 / 生活習慣 / 脂質異常 / 精神症状 / 地域住民 |
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| Outline of Final Research Achievements |
An investigation of intestinal microbiota was integrated into the health checkups of residents from Akita Prefecture, aged between 30 and 75 years, with a sample size of 407 individuals surveyed from 2019 to 2022.
The gender-based analysis revealed a higher prevalence of Bifidobacteria and Lactobacilli in women compared to men. Furthermore, a correlation was observed between alcohol consumption and reduced levels of these beneficial bacteria, particularly in men who reported an average intake of two or more alcoholic beverages daily, in comparison to their counterparts consuming less.
Additionally, individuals exhibiting depressive symptoms were found to have lower fiber intake and increased proportions of Ruminococcus spp. Strikingly, the likelihood of depression in men was greater in the group with a high Shannon diversity index as opposed to those in the low index group.
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| Free Research Field |
疫学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、地域住民の健診に併せて腸内細菌検査を行った結果、男性よりも女性の方に善玉菌である乳酸菌やビフィズス菌が多く、男性では多量飲酒が善玉菌を減らす方向に働くことが明らかになった。また、うつ症状など精神疾患と腸内細菌との関連もみられた。近年、腸内細菌と脂肪及び脳機能との関連が報告されるようになってきたが、本研究の結果、腸内細菌は飲酒などの生活習慣によっても影響を受けることから、心理的ストレスが飲酒量の増加を介して腸内細菌に影響する可能性も示唆された。今回、脂肪との関連は明らかではなかったが、今後対象地域を増やすことにより、脳ー腸ー脂肪連関を詳細に検討する必要がある。
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