The establishing a novel technical measure of nutritional status using a biomarker in the wound fluid.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K21731
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 58:Society medicine, nursing, and related fields
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: Yamane Takumi 東京農業大学, 応用生物科学部, 准教授 (80637314)
• Project Period (FY): 2020-07-30 – 2023-03-31
• Keywords: 創傷治癒 / 褥瘡 / 滲出液 / Adiponectin

Outline of Final Research Achievements

It is necessary to establish a brief and simplified method for evaluation of nutritional status during the wound healing process because malnutrition is closely associated with protracted wound healing. In the present study, we used an animal model to examine effects of a low protein (LP) diet on wound fluid component changes in rats. The concentrations of adiponectin in the wound fluid from rats fed a PF diet markedly changed, but this abnormality was reversed by refeeding a control diet. These results show that adiponectin in the wound fluid is available as a nutritional biomarker. This study would contribute to the establishing a novel technical measure of nutritional status during the wound healing process.

Free Research Field

分子栄養学

Academic Significance and Societal Importance of the Research Achievements

本研究課題は、これまでの創傷ケアでは単に廃棄されてきた滲出液を合目的に変化させ、タンパク質栄養の評価ツールとして利用するという、全く新しいコンセプトの管理手段の提案となり、患者だけでなく看護の者にもたらす恩恵は極めて大きいといえる。この方法を用いれば、在宅において簡易的かつ安全で患者に負担をかけることなく、医師や看護師などの医療従事者でなくとも栄養状態の把握が可能である。将来的にこの評価方法が臨床現場や在宅で導入されれば、寝たきり高齢者の低タンパク質栄養状態の早期発見につながり、効果的な栄養ケアの介入を行うことが可能となることが考えられる。