2021 Fiscal Year Final Research Report
Exploration of cancer cell microenvironment network focusing on the adipocytes
Project/Area Number |
20K21743
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
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Research Institution | Tohoku University |
Principal Investigator |
OWADA Yuji 東北大学, 医学系研究科, 教授 (20292211)
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Co-Investigator(Kenkyū-buntansha) |
宮崎 啓史 東北大学, 医学系研究科, 助教 (90803867)
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Project Period (FY) |
2020-07-30 – 2022-03-31
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Keywords | メラノーマ / 脂肪酸 / 脂肪酸結合タンパク質 / リンパ球 |
Outline of Final Research Achievements |
It has been shown that nutritional imbalance, especially unbalanced lipid intake, is closely related to lifestyle-related diseases such as diabetes and hypertension. Obesity, in particular, is considered a factor that influences the risk of carcinogenesis such as breast cancer and the prognosis of cancer, but the mechanisms involved are still unclear. In this study, we investigated the effects of the lipid microenvironment within and around tumors on proliferation and invasion. As a result, it became clear that the lipid environment dramatically changes the activation status of immune cells around tumors including melanoma, and eventually influence the tumor progression.
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Free Research Field |
栄養科学、腫瘍生物学
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果により腫瘍周囲の脂質微小環境が腫瘍の進展に関与する可能性が示された。組織内で癌細胞の周囲を取り巻いている脂肪細胞や各種免疫系細胞が、癌の増殖や浸潤に果たす役割を更に検証することで、脂質摂取や脂肪細胞のリポクオリティコントロールの観点から種々の癌の生物学的特性制御の実現に道を拓く可能性を秘めている。
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