• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2022 Fiscal Year Final Research Report

Identification and characterization of novel microRNAs secreted from muscle

Research Project

  • PDF
Project/Area Number 20K21753
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionNagoya University

Principal Investigator

Ouchi Noriyuki  名古屋大学, 医学系研究科, 特任教授 (00595514)

Co-Investigator(Kenkyū-buntansha) 大橋 浩二  名古屋大学, 医学系研究科, 特任准教授 (10595515)
竹藤 幹人  名古屋大学, 医学部附属病院, 講師 (20709117)
Project Period (FY) 2020-07-30 – 2023-03-31
Keywords持久性運動 / microRNA / 心腎血管疾患
Outline of Final Research Achievements

We found that miR185 acts as an exercise-inducible muscle-derived secretory microRNA “myomiRNA” in mice after screening of myomiRNAs which are upregulated in skeletal muscle by treadmill exercise training. Systemic delivery of miR185 mimic significantly reduced renal fibrosis in a mouse model of unilateral ureteral obstruction. Furthermore, miR185 suppressed expression of fibrotic markers in renal proximal tubular epithelial cells. Thus, miR185 may be a reno-protecitve secretory myomiRNA induced by endurance exercise.

Free Research Field

スポーツ医学

Academic Significance and Societal Importance of the Research Achievements

本研究では、持久性運動により誘発され、腎臓保護作用を示す新たな骨格筋由来分泌型microRNAが明らかとなった。本研究は慢性腎臓病の病態解明につながる可能性があるだけではなく、この骨格筋由来分泌型microRNAは腎臓以外の臓器に対する作用を示す可能性もあり、学術的意義は高いと考えられる。また、この骨格筋由来分泌型microRNAは運動による腎臓保護作用にも関わるため、運動すれば何故健康に有益なのか?という疑問に対する解決の糸口になり得る可能性があり、社会的意義は高いと考えられる。

URL: 

Published: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi