Molecular basis that positively protects hypothalamic function during the aging process

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21780
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: Satoh Akiko 国立研究開発法人国立長寿医療研究センター, 統合生理学研究部, 副部長 (80800979)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: 脳 / 老化 / トランスクリプトーム

Outline of Final Research Achievements

In this study, we tried to address whether genes, which newly generated with age in the hypothalamus, can maintain physiological function during the aging process. We identified genes that highly expressed in old mice compared with young mice by RNA-sequencing and that expressed in the hypothalamus and other brain regions, and then found that genes affect cell viability in neuronal cultures.

Free Research Field

老化生物学

Academic Significance and Societal Importance of the Research Achievements

老化寿命制御における脳の重要性が注目される中、老化過程において脳神経細胞の機能を積極的に維持するために新たに産生されその機能を発揮する分子を見出したことは、老化メカニズムの理解を深める上で役に立つ。また、将来的な老化への介入の糸口ともなる成果である。