2021 Fiscal Year Final Research Report
Development of an implantable sensory system that can approach safe and effective therapeutic interventions for neuropsychiatric disorders
| Project/Area Number |
20K21883
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
楠原 洋之 東京大学, 大学院薬学系研究科(薬学部), 教授 (00302612)
緒方 元気 大阪大学, 医学系研究科, 招へい教員 (80452829)
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Keywords | 針状ダイヤモンドセンサ / 局所薬物動態 / てんかん / 電気化学センサ / 自由行動下 |
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| Outline of Final Research Achievements |
Pharmacotherapy is the first-line treatment of epilepsy. Kinetics of anti-epileptic drugs in vivo is different between individual patients. This background leads to induction of severe adverse effects in some patients. To achieve personalized medication requires simultaneous detection of local drug kinetics, neuronal activity, and systemic conditions, each of which should change over time. To address this issue, in this study we constructed a prototype of the monitoring system implantable to the brain. This system contained a needle-type diamond microsensor, which tracks the drug concentrations as described in our earlier work. A preliminary assay with this implantable system monitored the three parameters after injection of an anti-epileptic drug. Moreover, for future in vivo experiments we optimized an analytical method for another drug with high stability and sensitivity. The system we proposed here would contribute to advances in personalized medication for patients with epilepsy.
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| Free Research Field |
薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
てんかんでは長期間に渡り投薬される場合があり、重篤な副作用が発生する場合も少なくない。急性期においても、患者によって効果が異なる場合がある。これらの問題を解決するためには、実際の脳内での薬物濃度と神経活動の推移と、全身症状との関係を経時的に比較する必要があるが、従来の方法では不可能であった。これらの同時測定を達成しうる本研究の埋め込み型薬物モニタリングシステムの試作品は、自由行動下の動物を対象とすることが可能であるため、長年の課題にアプローチする重要な技術となりうる。従って、医学的、社会的意義は極めて高い。
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