A development of two-photon peripheral neuroimaging and neural recording in tissue

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K21897
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Okayama University
• Principal Investigator: Kamiya Atsunori 岡山大学, 医歯薬学域, 教授 (30324370)
• Project Period (FY): 2020-07-30 – 2022-03-31
• Keywords: 自律神経

Outline of Final Research Achievements

The autonomic nerves are cables, that connect the brain with organs. They transmit command signals to individual organs and regulate their functions. In the present study, we have developed a new method to record individual nerve fiber activities and visualize neural dynamics in organs, and actually observed cellular-level autonomic neural structure and dynamics, which is difficult to be measured by existing methods. In addition, we also observed autonomic nerve innervations into cancer microenvironment.

Free Research Field

生体医工学

Academic Significance and Societal Importance of the Research Achievements

自律神経系は、曖昧に捉えられがちですが、本研究では、自律神経系を、個々の神経細胞レベルで、自律神経を実体のあるものとして捉えました。自律神経系は、健康や生命を維持する役割を担い、病態とも深く関わります。従って、本研究で開発した、自律神経線維の活動を解析する方法は、健康を支える自律神経の働きをより深く理解したり、様々な病気の仕組み（病態生理）を解明する上においても、役に立つように期待されます。