2022 Fiscal Year Final Research Report
Construction of basophil/liposome hybrid secretory system and its application to cell therapy and DDS.
Project/Area Number |
20K21906
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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Research Institution | Nagoya City University |
Principal Investigator |
Hirashima Naohide 名古屋市立大学, 医薬学総合研究院(薬学), 教授 (10192296)
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Project Period (FY) |
2020-07-30 – 2023-03-31
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Keywords | 分泌細胞 / 巨大リポソーム / 人工細胞 / 細胞治療 / DDS |
Outline of Final Research Achievements |
Aiming to construct a unique drug delivery system (DDS) based on liposomes, we has so far constructed an artificial exocytosis system by encapsulating small-iposomes in cell-sized giant liposomes. We also constructed targetting-cell therapy systems with high target specificity by modifying mast cells and basophils, which secrete by exocytosis in a target-dependent manner through antibodies. In this research, we fused the results of previous research, that is, fusing an artificial secretory cell and a living secretory cell(RBL-2H3 cell), resulting a new cellular therapy method and drug delivery system.
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Free Research Field |
生物物理学
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Academic Significance and Societal Importance of the Research Achievements |
全く新しい細胞治療およびDDSの観点からは、細胞サイズの巨大リポソームを基盤とした人工分泌細胞と生きた実在の分泌細胞の長所を生かした、ターゲット特異的分泌を行うハイブリッド分泌系の構築であること。 生物と非生物という観点からは、細胞サイズのリポソームと生細胞を融合させたハイブリッド系を、どこまで生細胞の性質と機能を保持して生存できるか、について挑戦することであり、その意義は応用面からも基礎研究の面からも極めて大きいと考える。
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