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2021 Fiscal Year Final Research Report

The female specific transcriptional regulation in murine meiosis

Research Project

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Project/Area Number 20K22638
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0701:Biology at molecular to cellular levels, and related fields
Research InstitutionKumamoto University

Principal Investigator

SHIMADA Ryuki  熊本大学, 発生医学研究所, 特定事業研究員 (10882798)

Project Period (FY) 2020-09-11 – 2022-03-31
Keywords生殖細胞 / 減数分裂 / 細胞周期 / マウス / STRA8 / Rb / pre-meiotic S phase
Outline of Final Research Achievements

The meiosis always start from S phase (celled pre-meiotic S phase). However, we still don't know the mechanism how meiotic initiation coincide with S phase. We revealed that the key factor of meiotic initiation, STRA8 interact with RB, which is the key suppressor of G1-S transition in canonical cell cycle, to induce pre-meiotic S phase. The regulation of pre-meiotic entry by STRA8-RB is critical for coordinated meiotic entry in female. Our study showed that STRA8-RB functions to ensure long term reproductive ability in mammalian female.

Free Research Field

生殖細胞発生学

Academic Significance and Societal Importance of the Research Achievements

減数分裂開始の制御と卵細胞の分化は遺伝的に独立した機構で制御されていると考えられてきた。しかし、我々の研究成果はメス生殖細胞においてSTRA8とRBが結合することでpre-meiotic S phaseと減数分裂の開始が適切な時期に起こることが、卵細胞を性成熟期まで維持するために必要であることが明らかとなった。これはこれまでの常識を覆す重要な発見である。さらにこのSTRA8-RBによる制御はメス特異的に機能しており、減数分裂の開始機構に雌雄差があることを明確に示す結果であり、今後の研究の方向性を変え得る重要な成果である。

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Published: 2023-01-30   Modified: 2025-03-27  

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