2021 Fiscal Year Final Research Report
Dynamics of orexin in sepsis
| Project/Area Number |
20K22731
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0802:Biomedical structure and function and related fields
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | 敗血症 / オレキシン |
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| Outline of Final Research Achievements |
Reduced CSF orexin levels gradually recovered as she recovered from sepsis. Unexpectedly, orexin was detected in the blood, which is unusual in healthy humans. Blood orexin was not detected after recovery from sepsis. This result may imply that orexin leaks into the blood because of BBB dysfunction. To the best of our knowledge, this is the first report investigating orexin levels in the CSF and blood of a patient with sepsis, and the data obtained from this case may provide a new understanding of the pathophysiology of SAE.
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| Free Research Field |
集中治療
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| Academic Significance and Societal Importance of the Research Achievements |
オレキシンが、減少した脳性髄液オレキシンを補充することで、敗血症から回復を促進したと考えられた。
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