2021 Fiscal Year Final Research Report
Pathophysiological functions of a multifunctional molecule, myoferlin, in adipose tissue and its involvement in individual aging
| Project/Area Number |
20K22873
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0902:General internal medicine and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
Nozato Yoichi 大阪大学, 医学系研究科, 助教 (50880390)
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | インスリン抵抗性 / 肥満 / 慢性炎症 |
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| Outline of Final Research Achievements |
Chronic inflammation and insulin resistance underlie the pathogenesis of obesity caused by lifestyle-related diseases such as diabetes and dyslipidemia. In this study, we found that myoferlin, which has been reported to be involved in fusion of cell membranes and intracellular vesicles and in endocytosis and recycling of receptor proteins, may promote chronic inflammation and aging in adipose tissue by inducing inflammation in macrophages through lysosomal exocytosis and impaired glucose metabolism through differentiation and hypertrophy of adipocytes.
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| Free Research Field |
動脈硬化 老化
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| Academic Significance and Societal Importance of the Research Achievements |
これまでMyoferlinは、筋細胞や各種癌細胞を中心として、細胞膜融合や細胞内小胞輸送、膜受容体のリサイクリング等に関連する病態生理機能が明らかにされていた。一方、生活習慣病の病態への関与の報告はなかった。本研究では、Myoferlinが代謝性疾患及びそれに付随する個体老化へも関与することを明らかにした。このようにMyoferlinの様々な加齢性疾患の病態の基盤に関わる多様な機能を有し、更に個体老化や寿命にも関与する可能性があることを示せたことに学術的意義がある。
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