Evaluation of molecular basis of 'AKI to CKD' and development of the preventive method using hypertensive rats

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22875
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Shimane University
• Principal Investigator: Egawa Masahiro 島根大学, 学術研究院医学・看護学系, 助教 (90799115)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 急性腎障害 / 慢性腎臓病 / 高血圧 / 高血圧自然発症ラット

Outline of Final Research Achievements

Acute kidney injury (AKI) is thought to be a risk factor for the onset of chronic kidney disease (CKD), however, the pathophysiological basis remains unclear. In this study, we aimed to investigate the underlying mechanisms of 'AKI to CKD' using spontaneously hypertensive rats (SHR). At least in the evaluation by ischemia/reperfusion (I/R) model, we found no pathological features of CKD. Further investigation is warranted to clear the underlying mechanisms of 'AKI to CKD'.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

高血圧は国内患者数が4000万人を超える国民病であり、かつAKIからCKDへの移行に関わる危険因子の一つと考えられている。有病率の高さに加え、高血圧それ自体が腎障害（腎硬化症）のリスク因子であることを考慮すると、AKI-CKDの病態連関における高血圧の病態生理学的役割を検証することは臨床的にも意義が高いと考えられる。