The role of prostaglandins and microbiota in small intestinal ulcer formation

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22929
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0903:Organ-based internal medicine and related fields
• Research Institution: Kyushu University
• Principal Investigator: Matsuno Yuichi 九州大学, 大学病院, 助教 (60876522)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 小腸潰瘍 / プロスタグランジン / 腸内細菌叢 / 非特異性多発性小腸潰瘍症 / CEAS / NSAIDs

Outline of Final Research Achievements

Although prostaglandins (PGs) are involved in the pathogenesis of both Chronic enteropathy associated with SLCO2A1 gene (CEAS) and NSAIDs-induced small intestinal ulcer, the pathogenesis of these disease is unclear. We conducted an RCT to clarify the involvement of intestinal microbiota in NSAIDs-induced small intestinal ulcer, and found that the incidence of small intestinal ulcer in the probiotic group was significantly lower than that in the placebo group. Analyzing the microbiota of the small intestine, we examined the differences in the microbiota in each part of the gastrointestinal tract. We are preparing to examine the changes in microbiota in NSAIDs-induced small intestinal ulcers and the expression of PG and its receptors and transporters in CEAS.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

プロバイオティクスによってNSAIDs起因性小腸潰瘍の発生率を有意に低くすることが示唆されたことにより、今後NSAIDs起因性小腸潰瘍の治療としてのプロバイオティクスの可能性が示された。また今後NSAIDｓ起因性小腸潰瘍の腸内細菌叢の検討により、NSAIDs起因性小腸潰瘍のみならず、CEASを含めたプロスタグランジン関連腸症の発症メカニズムの解明につながる可能性がある。また今回行った消化管各部位での細菌叢の相違の検討結果から、空腸と十二指腸では類似したクラスターが形成されており、空腸からの検体採取が困難であれば十二指腸から採取した検体も解析対象となりうる可能性が示唆された。