2022 Fiscal Year Final Research Report
Novel treatment for peri-implantitis using carbon nanohorns as a DDS carrier
| Project/Area Number |
20K23013
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
Maeda Yukari 北海道大学, 大学病院, 医員 (40884622)
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| Project Period (FY) |
2020-09-11 – 2023-03-31
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| Keywords | カーボンナノホーン / ミノサイクリン / インプラント周囲炎 / 局所薬物送達療法 / 動物実験 |
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| Outline of Final Research Achievements |
Gelatinized MC/CNHs did not show inflammatory properties when implanted subcutaneously in rats using bioabsorbable hydro gelatin gel. A rat model of periodontitis was created by immediate placement of titanium screws after extraction of rat first molars, and ligature wires were wrapped around the gingival sulcus after 4 weeks.
Chlorhexidine (CHX), benzalkonium chloride (BAC), levofloxacin, and FGF were successfully prepared in complex with CNHs. However, the results of the cell culture using S. mutans bacteria suggested that CHX and BAC may reduce the disinfection effect of CNHs by loading them on CNHs.
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| Free Research Field |
補綴歯科学
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| Academic Significance and Societal Importance of the Research Achievements |
ラット皮下に化学架橋剤不使用の生体吸収性ハイドロゼラチンゲルに包埋したMC/CNHsを注入し，炎症を惹起しなかったことから，in vivoでの安全性が確立された．CNHsと薬剤を複合体とすることでCNHsの分散性を向上させ，さらに静菌作用等の付帯効果を与えることが可能となった．この特徴を用いてインプラント周囲炎への局所薬物送達療法への応用が期待できると考えている．
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