2021 Fiscal Year Final Research Report
Identification of periodontal ligament stem cells contributing to the orthodontic tooth movement
| Project/Area Number |
20K23023
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | 歯根膜 / 増殖活性 / 幹細胞 / 矯正的歯の移動 |
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| Outline of Final Research Achievements |
Proliferating cells in the periodontal ligament temporarily increased with orthodontic force, and changes in proliferative activity were observed throughout the tissue. In cell tracking experiments using RGBow, clusters of proliferatively active cells were formed throughout the tissue. Furthermore, proliferating cells expressed various differentiation markers and were composed of diverse cell groups.
This study indicates that the cellular supply of the mouse molar periodontal ligament under mechanical stimulation is not carried by specific cells, but by a variety of cells.
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| Free Research Field |
歯科矯正学分野
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| Academic Significance and Societal Importance of the Research Achievements |
本研究が示した歯根膜細胞の力学的刺激に対する特性は，歯科臨床における組織恒常性の理解と，革新的な治療法の開発における基礎的知見として極めて意義の高いものである.
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