Research to expand the safe use of Dexmedetomidine in dentistry

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K23096
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: The Nippon Dental University
• Principal Investigator: Hashizume Nana 日本歯科大学, 生命歯学部, 助教 (40824066)
• Project Period (FY): 2020-09-11 – 2023-03-31
• Keywords: Dexmedetomidine / RSA / α2アドレナリン受容体 / イミダゾリン1受容体

Outline of Final Research Achievements

Present study examined the effect of dexmedetomidine (α2-adrenoceptor/imidazoline 1 receptor agonist) in adult rats, following our previous examination in newborn rats. The adult rats showed hypopnea as those seen in newborn rats and with a help of arterial catheter the increases in PaCO2 and arterial blood pressure could be obtained in adult rats after intravenous administration of dexmedetomidine (50 μg/kg). Different from newborn rats, a possible stimulant effect of dexmedetomidine on the respiratory drive through imidazoline 1 receptor activation was not seen in adult rats. These results suggest that cardiorespiratory effects of dexmedetomidine could be dynamically changed by postnatal development. In addition, the results indicated that adult rats have a larger numerical value of respiratory sinus arrhythmia, compared to those in newborn rats.

Free Research Field

呼吸生理学

Academic Significance and Societal Importance of the Research Achievements

本研究によって、Dexmedetomidineの特にImidazoline1受容体を介した呼吸循環への効果は成長により変化することが示唆された。これらの結果は、現在使用拡大が広がっているDEXのより安全で有用な使用に有益な情報をもたらすと確信している。加えて、ラットでもrespiratory sinus arrhythmia(RSA)の測定が可能であり、新生仔と比べて成熟ラットで明らかに数値が大きくなることが示された。RSAは呼吸と循環の協調性を表す１つの指標となるので、ラットがその動物モデルとなり得ることを示すことができた意義は大きい。