Development of a treatment method for intractable peri-implantitis using BMP-2 -containing artificial periosteum

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K23108
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Okayama University
• Principal Investigator: nosho shuji 岡山大学, 大学病院, 医員 (40884797)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: rhBMP-2含有人工骨膜 / 歯科用メンブレン

Outline of Final Research Achievements

In this study, we tried to create artificial periosteum that contains recombinant human bone Morphogenetic Protein-2 (rh-BMP-2) by using a new dental membrane that has absorbability of materials in only one side, although our first plan was to research validity of artificial periosteum that contains rh-BMP-2 by using PLGA-membrane. We made a hypothesis that the new membrane that contains rh-BMP-2 in only one side could promote new bone formation only inside of membrane, and control the shape of alveolar ridge after bone regenerative therapy. We revealed that the freeze-dried the new membrane contains rh-BMP-2 could promote new bone formation only inside of membrane, and the bone forming effect of new membrane contained rh-BMP-2 is almost same as PLGA-membrane.

Free Research Field

骨再生療法

Academic Significance and Societal Importance of the Research Achievements

我々はこれまでにBMP-2/β-TCP複合体による骨組織の再生に成功してるが、この再生骨は海綿骨が中心であり，インプラント体のオッセオインテグレーションの獲得に有利な皮質骨の効率的な再生には至っていない．本研究におけるrhBMP-2含有人工骨膜の応用により，インプラント周囲炎，および感染や粉砕骨折，血行不全により骨膜の機能不全が原因で一つの骨再生プロセスが途中で停止し生じる偽関節といった疾患に対する新たな治療法を確立できる可能性がある．また，本人工骨膜を歯科用インプラントを用いた治療に先立ち骨増生を行う際のメンブレンとして使用すれば，皮質骨組織と海綿骨組織の双方の再生を図れる可能性がある．