2021 Fiscal Year Final Research Report
Neural substrate of model-based action selection
| Project/Area Number |
20K23339
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
1002:Human informatics, applied informatics and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | 強化学習 / 機械学習 / マウス / 光遺伝学 |
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| Outline of Final Research Achievements |
Humans and animals decide behavior not only based on past experiences (i.e., habit), but also make choices by estimating a current context from sensory inputs and experiences. This context-dependent complex behavior is known as a goal-directed behavior. To investigate the neural substrate of goal-directed behavior, our study proposed a context-estimation behavioral task in mice. During the task, we opto-genetically inactivated the neural activity of mouse dorsal cortex, and found that the anterior lateral motor cortex (ALM) was involved in selecting the left or right spout.
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| Free Research Field |
ニューロAI
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は，ヒトや動物の習慣的・本能的な行動ではなく，目的志向の複雑な行動選択時の脳機能をマウスで検証した．本研究は，まず，最先端の遺伝子改変技術を活用できるマウスで，目的志向行動の神経基盤を検証可能なことを示す．今後の詳細な神経基盤解明につながる．また，本研究は，前外側運動皮質の行動選択への寄与を確認した．本研究は将来，脳の意思決定機構を反映した脳型人工知能の構築や，意思決定に変調を伴う脳疾患の基礎的理解につながる．
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