2022 Fiscal Year Final Research Report

International study for clinical significance of anti-erythropoietin receptor antibodies as a biomarker candidate in patients with diabetic kidney disease

Research Project

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Project/Area Number	20KK0191
Research Category	Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 52:General internal medicine and related fields
Research Institution	Kanazawa University
Principal Investigator	Wada Takashi 金沢大学, その他部局等, その他 (40334784)
Co-Investigator(Kenkyū-buntansha)	遠山直志金沢大学, 附属病院, 特任教授 (50624871) 原章規金沢大学, 医学系, 准教授 (70507045) 大島恵金沢大学, 附属病院, 特任助教 (80802066)
Project Period (FY)	2020-10-27 – 2023-03-31
Keywords	糖尿病性腎臓病 / 抗エリスロポエチン受容体抗体 / 国際共同研究 / バイオマーカー / 糖尿病
Outline of Final Research Achievements	This study was aimed to determine the significance of anti-erythropoietin receptor (EPOR) antibodies, which we have already established, in clinical outcomes and their related risk factors in patients with diabetic nephropathy (diabetic kidney disease) comparing to our Japanese database. We have established international collaborative research team among international cohorts. Our study revealed that higher levels of anti-EPOR antibodies were associated with an increased risk of kidney outcome. In addition, prognostic risk factors including the presence of anti-EPOR antibodies from our Japanese database were closely relevant to those of patients examined. Taken together, these results suggested that anti-EPOR antibodies could be a promising biomarker candidate in predicting kidney disease progression in patients with diabetic nephropathy (diabetic kidney disease).
Free Research Field	腎臓学、内科学、臨床検査医学
Academic Significance and Societal Importance of the Research Achievements	本邦では糖尿病性腎症(糖尿病性腎臓病)は透析導入原疾患の第1位である。さらに、諸外国においても、糖尿病の増加とともに、その合併症である腎症の克服は重要な課題である。本研究の学術的な特色は、申請者らが独自に開発した抗エリスロポエチン受容体(EPOR)抗体を用いて国際的糖尿病性腎臓病コホート検体を測定し、腎症の病態や予後との関連を検討した点にある。さらに、本邦の代表的なコホートから得られた成果と病態などの国際比較、検証を行った点にある。本研究は新規国際的バイオマーカーとしての意義の確立を目指すものであり、学術的意義ならびに社会的意義が深い。