Toward reconstructing psychiatric disorders based on brain structure and function: International joint research project

2020 Fiscal Year Research-status Report

• Project/Area Number: 20KK0193
• Research Institution: Kyushu University
• Principal Investigator: 平野 羊嗣 九州大学, 大学病院, 助教 (90567497)
• Co-Investigator(Kenkyū-buntansha): 小池 進介 東京大学, 大学院総合文化研究科, 准教授 (10633167) ; 中島 振一郎 慶應義塾大学, 医学部(信濃町), 助教 (60383866) ; 笹林 大樹 富山大学, 学術研究部医学系, 助教 (80801414)
• Project Period (FY): 2020-10-27 – 2025-03-31
• Keywords: 精神疾患 / バイオタイプ / 脳構造 / 脳機能 / 国際共同研究

Outline of Annual Research Achievements

本国際協同研究は、精神疾患の共通性/異種性バイオタイプ開発を視野に入れた、アジア発の精神疾患の脳構造・脳機能研究の拠点構築を目標とする。本国際協同研究により『脳構造と脳機能から精神疾患を再定義』することで、精神疾患全体の本質的な理解と治療法の再構築を目指す。しかしながら、殆どの参画施設が大学病院であるため、2020年度はCOVID-19感染拡大による多大な影響を受けた。各自の実績は以下の通り。
＜平野＞大学病院の指針に従いながら、年度の後半に研究を再開した。海外の脳波関連の共同研究施設とはWEB会議で連携しつつ、臨床脳波を用いた国内の共同研究（７施設）に関する整備とデータ収集、解析パイプラインの構築を行った。また、本研究に関わる論文16本を国際専門誌に投稿した。
＜小池＞COVID-19感染拡大の影響で、2021年1月より可能な範囲で実験を再開した。2020年度末までに日本5施設、韓国3施設からデータの受け取りを完了し、前処理を開始した。データクリーニングが終わったデータセットより、各ACMP機関へデータの提供を開始した。
＜中島＞自施設の統合失調症データを継続的に蓄積しながら、治療反応性に注目し、マルチモーダルMRIの解析を行い、DTIや1H-MRS（グルタミン酸、グルタチオン）について論文発表した。メタボロミクスやTMS-EEGなどの他のモダリティのデータも蓄積しており、解析体制を整えてきた。今後、これらのモダリティにより取得したデータを用いて多変量解析を行う予定である。
＜笹林＞大規模データベース（ACMP）のマルチモダリティ解析に先立って、複数の新たな脳構造指標の解析技術および複数プロトコルデータ間の計測バイアスの補正手法を習得した。自施設のMRIデータを用いて予備的な解析を開始し、今年度は統合失調症および統合失調症ハイリスク群における海馬亜領域の体積変化について公表した。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

2020年度は、COVID-19感染症拡大が日本をはじめとしたアジア諸国に多大な影響を与えた。特に、本共同研究の殆どの参画施設が大学附属病院であるため、研究活動そのものを長く中断せざるを得なかった。各参画施設や病院の指針に従いながら、随時実験を再開し、データ収集とその解析を行ったが、当初の研究計画よりはやや遅れている状況が続いている。ただし、海外の脳波・MRI/MRS関連の共同研究施設とはWEB会議で連携しつつ、臨床脳波とMRIやMRSといったマルチモダリティ解析のための国内外の共同研究に関する整備と、データ収集、解析パイプラインの構築を行った。また、本研究に関わる論文74本（平野：16本、小池：22本、中島：24本、　笹林：12本）を国際専門誌に投稿しており、一定以上の結果は出すことが出来たと考える。

Strategy for Future Research Activity

2021年4月時点においても、COVID-19感染症に関する本協同研究計画に対する影響は続いており、殆ど全ての研究参画機関で実験や計測の中断もしくは遅延が発生している。また、渡航制限により、海外のみならず国内の移動も制限されており、人的交流、人材育成に対する影響も著しく、本国際協同研究の遅れが懸念される。今後は、感染拡大状況を注視しつつ、各参画施設や病院の指針に従いながら、随時実験を再開し、データ収集とその解析、また既存データの集積と解析も合わせて行っていく。さらに、国内外の脳波・MRI/MRS関連の共同研究施設とは引き続きWEB会議等で連携しつつ研究を推進していく。

Causes of Carryover

2020年度は、COVID-19感染症拡大の影響により、予定していた本国際共同研究に関わる国内外の出張ができず、加えて本共同研究の殆どの参画施設が大学病院であるため、研究活動そのものを一時的に中断せざるを得なかったため、その他付随して発生する費用の支出が予定より見込めず、次年度に繰り越すこととした。今後は、感染拡大状況を注視しつつ、各参画施設や病院の指針に従いながら、随時実験を再開し、データ収集とその解析、また既存データの集積と解析も合わせて行っていく。さらに、国内外の共同研究施設とは引き続きWEB会議等で連携しつつ研究を推進していく。

Research Products

• [Int'l Joint Research] Harvard Medical School/Children's Hospital of Philadelphia/Johns Hopkins University(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Harvard Medical School/Children's Hospital of Philadelphia/Johns Hopkins University
• [Int'l Joint Research] University of Toronto/McGill University/University Ottawa(カナダ)
  • Country Name: CANADA
  • Counterpart Institution: University of Toronto/McGill University/University Ottawa
• [Int'l Joint Research] The University of Melbourne/Melbourne Health(オーストラリア)
  • Country Name: AUSTRALIA
  • Counterpart Institution: The University of Melbourne/Melbourne Health
• [Int'l Joint Research] National Taiwan University Hospital/National Cheng Kung University Hospital/Peking University(中国)
  • Country Name: CHINA
  • Counterpart Institution: National Taiwan University Hospital/National Cheng Kung University Hospital/Peking University
  • # of Other Institutions: 1
• [Int'l Joint Research] Seoul National University/Chonbuk National University Hospital/CHA Bundang Medical Center(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: Seoul National University/Chonbuk National University Hospital/CHA Bundang Medical Center
• [Int'l Joint Research]
  • # of Other Countries: 2
• [Journal Article] Shared functional impairment in the prefrontal cortex affects symptom severity across psychiatric disorders (2022)
  • Author(s): Koike S, Sakakibara E, Satomura Y, Sakurada H, Yamagishi M, Matsuoka J, Okada N, Kasai K
  • Journal Title: Psychological Medicine Volume: 52 Pages: 2661-2670
  • DOI: 10.1017/S0033291720004742
  • Peer Reviewed
• [Journal Article] Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study (2022)
  • Author(s): Takahashi T, Tsugawa S, Nakajima S, Plitman E, Chakravarty MM, Masuda F, Wada M, Kurose S, Ochi R, Matsushita K, Sasabayashi D, Nakamura M, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Hashimoto R, Noguchi K, Fujii S, Mimura M, Noda Y, Suzuki M
  • Journal Title: Schizophrenia Research Volume: 243 Pages: 268-275
  • DOI: 10.1016/j.schres.2020.04.016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Current MEG Research in Psychiatry (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 647085
  • DOI: 10.3389/fpsyt.2021.647085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study (2021)
  • Author(s): Jinya Sato, Yoji Hirano*, Noriaki Hirakawa, Junichi Takahashi, Naoya Oribe, Hironori Kuga, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao, Toshiaki Onitsuka
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 121-121
  • DOI: 10.3390/jpm11020121
  • Peer Reviewed / Open Access
• [Journal Article] Effects of age and sex on eye movement characteristics (2021)
  • Author(s): Junichi Takahashi, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Seiko Miyata, Kosuke Okazaki, Junya Matsumoto, Naomi Hasegawa, Yoji Hirano, Hidenaga Yamamori, Yuka Yasuda, Manabu Makinodan, Kiyoto Kasai, Norio Ozaki, Toshiaki Onitsuka, Ryota Hashimoto
  • Journal Title: Neuropsychopharmacology Reports Volume: 41 Pages: 152-158
  • DOI: 10.1002/npr2.12163
  • Peer Reviewed / Open Access
• [Journal Article] Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review (2021)
  • Author(s): Alexandra Wolf, Kazuo Ueda, Yoji Hirano*
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Pages: 82-100
  • DOI: 10.1111/pcn.13188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dietary restraint related to body weight maintenance and neural processing in value-coding areas in adolescents (2021)
  • Author(s): Nakamura Y, Ando S, Yamasaki S, Okada N, Nishida A, Kasai K, Tanaka S, Nakatani H, Koike S
  • Journal Title: J Nutr Volume: 151 Pages: 2059-67
  • DOI: 10.1093/jn/nxab068
  • Peer Reviewed
• [Journal Article] Association of disinhibited eating and trait of impulsivity with insula and amygdala responses to palatable liquid consumption (2021)
  • Author(s): Nakamura Y, Koike S
  • Journal Title: Front System Neurosci Volume: 15 Pages: 647143
  • DOI: 10.3389/fnsys.2021.647143
  • Peer Reviewed / Open Access
• [Journal Article] Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study (2021)
  • Author(s): Ohi K, Ochi R, Noda Y, Wada M, Sugiyama S, Nishi A, Shioiri T, Mimura M, Nakajima S.
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 187
  • DOI: 10.1038/s41398-021-01308-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis (2021)
  • Author(s): Kinjo M, Wada M, Nakajima S, Tsugawa S, Nakahara T, Blumberger DM, Mimura M, Noda Y.
  • Journal Title: Psychological Medicine Volume: 51 Pages: 1-10
  • DOI: 10.1017/S0033291720004729
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Recent findings on neurofeedback training for auditory hallucinations in schizophrenia (2021)
  • Author(s): Hirano Y* and Tamura S
  • Journal Title: Current Opinion in Psychiatry Volume: 34 Pages: 245～252
  • DOI: 10.1097/YCO.0000000000000693
  • Peer Reviewed / Open Access
• [Journal Article] Structural MRI measures associated with psychosis onset in individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group mega-analysis (2021)
  • Author(s): Jalbrzikowski M, Hayes RA, Wood SJ, Nordholm D, Zhou JH, Fusar-Poli, P, Uhlhaas, PJ, Takahashi T, Sugranyes, G, Kwak, YB, Mathalon, DH, Katagiri, N, Hooker CI, Smigielski L, Colibazzi T, Via E, Tang J, Koike S et al
  • Journal Title: JAMA Psychiatry Volume: - Pages: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brain/MINDS Beyond Human Brain MRI Group: Brain/MINDS Beyond Human Brain MRI Project: A protocol for multi-level harmonization across brain disorders throughout the lifespan (2021)
  • Author(s): Koike S, Tanaka SC, Okada T, Aso T, Yamashita A, Yamashita O, Asano M, Maikusa N, Morita K, Okada N et al
  • Journal Title: Neuroimage Clin Volume: - Pages: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of Metacognition in Adolescence: The Congruency-Based Metacognition Scale (2021)
  • Author(s): Kawata KH, Ueno Y, Hashimoto R, Yoshino S, Ohta K, Nishida A, Ando S, Nakatani H, Kasai K, Koike S
  • Journal Title: Frontiers in Psychology Volume: 11 Pages: 565231
  • DOI: 10.3389/fpsyg.2020.565231
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis (2021)
  • Author(s): Mimura Y, Nishida H, Nakajima S, Tsugawa S, Morita S, Yoshida K, Tarumi R, Ogyu K, Wada M, Kurose S, Miyazaki T, Blumberger DM, Daskalakis ZJ, Chen R, Mimura M, Noda Y
  • Journal Title: Neuroscience & Biobehavioral Reviews Volume: 121 Pages: 47～59
  • DOI: 10.1016/j.neubiorev.2020.12.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Measuring amphetamine-induced dopamine release in humans: A comparative meta-analysis of [ 11 C]-raclopride and [ 11 C]-(+)-PHNO studies (2021)
  • Author(s): Caravaggio F, Porco N, Kim J, Torres-Carmona E, Brown E, Iwata Y, Nakajima S, Gerretsen P, Remington G, Graff-Guerrero A
  • Journal Title: Synapse Volume: - Pages: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lower striatal dopamine D2/3receptor availability in obsessive-compulsive disorder: A meta-analysis of [11C]-raclopride and [123I]-IBZM studies (2021)
  • Author(s): Caravaggio F, Porco N, Iwata Y, Nakajima S, Gerretsen P, Remington G, Graff-Guerrero A
  • Journal Title: Journal of Obsessive-Compulsive and Related Disorders Volume: 28 Pages: 100618～100618
  • DOI: 10.1016/j.jocrd.2020.100618
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutathione Levels and Glutathione-Glutamate Correlation in Patients with Treatment-Resistant Schizophrenia (2021)
  • Author(s): Nakajima S, Iwata Y, Plitman E, Truong P, Bani-Fatemi A, Caravaggio F, Kim J, Shah P, Chavez S, Remington G, Gerretsen P, De Luca V, Sailasuta N, Graff-Guerrero A
  • Journal Title: Schizophrenia Bulletin Open Volume: - Pages: sgab006
  • DOI: 10.1093/schizbullopen/sgab006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 40
  • DOI: 10.3390/jpm11010040
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration (2021)
  • Author(s): Sasabayashi D, Takahashi T, Takayanagi Y, Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 176
  • DOI: 10.1038/s41398-021-01297-8
  • Peer Reviewed / Open Access
• [Journal Article] Reduced Hippocampal Subfield Volume in Schizophrenia and Clinical High-Risk State for Psychosis (2021)
  • Author(s): Sasabayashi D, Yoshimura R, Takahashi T, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Nakamura M, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 642048
  • DOI: 10.3389/fpsyt.2021.642048
  • Peer Reviewed / Open Access
• [Journal Article] Prospects for Future Methodological Development and Application of Magnetoencephalography Devices in Psychiatry (2020)
  • Author(s): Hironaga N, Takei Y, Mitsudo T, Kimura K, Hirano Y
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 863
  • DOI: 10.3389/fpsyt.2020.00863
  • Peer Reviewed / Open Access
• [Journal Article] Language-Related Neurophysiological Deficits in Schizophrenia (2020)
  • Author(s): Hirano S, Spencer KM, Onitsuka T, Hirano Y*
  • Journal Title: Clinical EEG and Neuroscience Volume: 51 Pages: 222～233
  • DOI: 10.1177/1550059419886686
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of self‐reported religiosity with the development of major depression in multireligious country Japan (2020)
  • Author(s): Kobayashi D*, First MB, Shimbo T, Kanba S, Hirano Y*
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Pages: 535～541
  • DOI: 10.1111/pcn.13087
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study (2020)
  • Author(s): Ohara N, Hirano Y*, Oribe N, Tamura S, Nakamura I, Hirano S, Tsuchimoto R, Ueno T et al
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 554844
  • DOI: 10.3389/fpsyt.2020.554844
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Test-Retest Reliability of Auditory Gamma Oscillations Between Different Clinical EEG Systems (2020)
  • Author(s): Hirano Y*, Nakamura I, Tamura S, Onitsuka T
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 876
  • DOI: 10.3389/fpsyt.2020.00876
  • Peer Reviewed / Open Access
• [Journal Article] Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia (2020)
  • Author(s): Hirano Y, Oribe N, Onitsuka T, Kanba S, Nestor PG, Hosokawa T, Levin M, Shenton ME, McCarley RW, Spencer KM
  • Journal Title: Clinical EEG and Neuroscience Volume: 51 Pages: 244～251
  • DOI: 10.1177/1550059420914201
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal evaluation of visual P300 amplitude in clinical high‐risk subjects: An event‐related potential study (2020)
  • Author(s): Oribe N, Hirano Y, Del Re E, Mesholam-Gately RI, Woodberry KA, Ueno T, Kanba S, Onitsuka T, Shenton ME, Spencer KM, Niznikiewicz MA
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Pages: 527～534
  • DOI: 10.1111/pcn.13083
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Altered P3a Modulations to Emotional Faces in Male Patients With Chronic Schizophrenia (2020)
  • Author(s): Onitsuka T, Spencer KM, Nakamura I, Hirano Y, Hirano S, McCarley RW, Shenton ME, Niznikiewicz MA
  • Journal Title: Clinical EEG and Neuroscience Volume: 51 Pages: 215～221
  • DOI: 10.1177/1550059419896723
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real‐world multisite study (2020)
  • Author(s): Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y et al
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Pages: 56～63
  • DOI: 10.1111/pcn.12934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study (2020)
  • Author(s): Hirakawa N, Kuga H, Hirano Y, Sato J, Oribe N, Nakamura I, Hirano S, Ueno T, Oda Y, Togao O, Hiwatashi A, Honda H, Kanba S, Onitsuka T
  • Journal Title: Brain Imaging and Behavior Volume: 14 Pages: 1382～1387
  • DOI: 10.1007/s11682-019-00044-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prefrontal dysfunction associated with a history of suicide attempts among patients with recent onset schizophrenia (2020)
  • Author(s): Matsuoka J, Koike S, SatomuraY, Okada N, Nishimura Y, Sakakibara E, Sakurada H, Yamagishi M, Takahashi K, Takayanagi Y, Kasai K
  • Journal Title: npj Schizophrenia Volume: 6 Pages: 29
  • DOI: 10.1038/s41537-020-00118-z
  • Peer Reviewed / Open Access
• [Journal Article] Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia (2020)
  • Author(s): Ikegame T, Bundo M, Okada N, Murata Y, Koike S et al
  • Journal Title: Schizophrenia Bulletin Volume: 46 Pages: 1577～1586
  • DOI: 10.1093/schbul/sbaa075
  • Peer Reviewed / Open Access
• [Journal Article] Difference in neural reactivity to taste stimuli and visual food stimuli in neural circuits of ingestive behavior (2020)
  • Author(s): Nakamura Y, Okada N, Koshiyama D, Kamiya K, Abe O, Kunimatsu A, Okanoya K, Kasai K, Koike S
  • Journal Title: Brain Imaging and Behavior Volume: 14 Pages: 1395～1405
  • DOI: 10.1007/s11682-019-00048-0
  • Peer Reviewed / Open Access
• [Journal Article] Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State (2020)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Katagiri N, Sakuma A, Obara C, Katsura M, Okada N, Koike S, Yamasue H, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Kasai K, Suzuki M
  • Journal Title: Schizophrenia Bulletin Volume: 46 Pages: 834～845
  • DOI: 10.1093/schbul/sbaa011
  • Peer Reviewed / Open Access
• [Journal Article] Caudate Functional Connectivity Associated With Weight Change in Adolescents (2020)
  • Author(s): Nakamura Y, Ozawa S, Koike S
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: e587763
  • DOI: 10.3389/fnhum.2020.587763
  • Open Access
• [Journal Article] Auditory Mismatch Negativity Under Predictive Coding Framework and Its Role in Psychotic Disorders (2020)
  • Author(s): Fong CY, Law WH, Uka T, Koike S
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: e557932
  • DOI: 10.3389/fpsyt.2020.557932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence (2020)
  • Author(s): Koshiyama D, Okada N, Ando S, Koike S, Yahata N, Morita K, Sawada K, Morita S, Kawakami S, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Araki T, Kano Y, Endo K, Yamasaki S, Nishida A, Hiraiwa-Hasegawa M, Kasai K
  • Journal Title: NeuroImage Volume: 220 Pages: 117083～117083
  • DOI: 10.1016/j.neuroimage.2020.117083
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurometabolic underpinning of the intergenerational transmission of prosociality (2020)
  • Author(s): Okada N, Yahata N, Koshiyama D, Kentaro M, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Edden R, Sawa A, Kasai K
  • Journal Title: NeuroImage Volume: 218 Pages: 116965～116965
  • DOI: 10.1016/j.neuroimage.2020.116965
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Association Between Amygdala Subfield-Related Functional Connectivity and Stigma Reduction 12 Months After Social Contacts: A Functional Neuroimaging Study in a Subgroup of a Randomized Controlled Trial (2020)
  • Author(s): Nakamura Y, Okada N, Ando S, Ohta K, Ojio Y, Abe O, Kunimatsu A, Yamaguchi S, Kasai K, Koike S
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: 356
  • DOI: 10.3389/fnhum.2020.00356
  • Peer Reviewed / Open Access
• [Journal Article] Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis (2020)
  • Author(s): Fujioka M, Kirihara K, Koshiyama D, Tada M, Nagai T, Usui K, Morita S, Kawakami S, Morita K, Satomura Y, Koike S, Suga M, Araki T, Kasai K
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 770
  • DOI: 10.3389/fpsyt.2020.00770
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Machine-learning classification using neuroimaging data in schizophrenia, autism, ultra-high risk and first-episode psychosis (2020)
  • Author(s): Yassin Walid、Nakatani Hironori、Zhu Yinghan、Kojima Masaki、Owada Keiho、Kuwabara Hitoshi、Gonoi Wataru、Aoki Yuta、Takao Hidemasa、Natsubori Tatsunobu、Iwashiro Norichika、Kasai Kiyoto、Kano Yukiko、Abe Osamu、Yamasue Hidenori、Koike Shinsuke
  • Journal Title: Translational Psychiatry Volume: 10 Pages: 278
  • DOI: 10.1038/s41398-020-00965-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Global DNA hypomethylation and its correlation to the betaine level in peripheral blood of patients with schizophrenia (2020)
  • Author(s): Murata Y, Ikegame T, Koike S, Saito T, Ikeda M, Sasaki T, Iwata N, Kasai K, Bundo M, Iwamoto K
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 99 Pages: 109855～109855
  • DOI: 10.1016/j.pnpbp.2019.109855
  • Peer Reviewed / Open Access
• [Journal Article] Smaller anterior subgenual cingulate volume mediates the effect of girls’ early sexual maturation on negative psychobehavioral outcome (2020)
  • Author(s): Okada N, Yahata N, Koshiyama D, Kentaro M, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Kasai K
  • Journal Title: NeuroImage Volume: 209 Pages: 116478～116478
  • DOI: 10.1016/j.neuroimage.2019.116478
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clozapine response trajectories and predictors of non-response in treatment-resistant schizophrenia: a chart review study (2020)
  • Author(s): Shah P, Iwata Y, Brown EE, Kim J, Sanches M, Takeuchi H, Nakajima S, Hahn M, Remington G, Gerretsen P, Graff-Guerrero A
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience Volume: 270 Pages: 11～22
  • DOI: 10.1007/s00406-019-01053-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early Improvements of Individual Symptoms With Antipsychotics Predict Subsequent Treatment Response of Neuropsychiatric Symptoms in Alzheimer’s Disease (2020)
  • Author(s): Nagata T, Shinagawa S, Yoshida K, Noda Y, Shigeta M, Mimura M. Nakajima S
  • Journal Title: The Journal of Clinical Psychiatry Volume: 81 Pages: 19m12961
  • DOI: 10.4088/JCP.19m12961
  • Peer Reviewed / Open Access
• [Journal Article] Noda Y, Barr MS, ElSalhy M, Masuda F, Tarumi R, Ogyu K, Wada M, Tsugawa S, Miyazaki T, Nakajima S, Mimura M (2020)
  • Author(s): Noda Yoshihiro、Barr Mera S.、ElSalhy Muhammad、Masuda Fumi、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Tsugawa Sakiko、Miyazaki Takahiro、Nakajima Shinichiro、Mimura Masaru
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 99 Pages: 109822～109822
  • DOI: 10.1016/j.pnpbp.2019.109822
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visualization of AMPA receptors in living human brain with positron emission tomography (2020)
  • Author(s): Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T, Serizawa A, Sano A, Kogami S, et al
  • Journal Title: Nature Medicine Volume: 26 Pages: 281～288
  • DOI: 10.1038/s41591-019-0723-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Levels of glutamatergic neurometabolites in patients with severe treatment-resistant schizophrenia: a proton magnetic resonance spectroscopy study (2020)
  • Author(s): Tarumi R, Tsugawa S, Noda Y, Plitman E, Honda S, Matsushita K, Chavez S, Sawada S, Wada M, Matsui M, Fujii S, Miyazaki T, Chakravarty MM, Uchida H, Remington G, Graff-Guerrero A, Mimura M, Nakajima S
  • Journal Title: Neuropsychopharmacology Volume: 45 Pages: 632～640
  • DOI: 10.1038/s41386-019-0589-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroanatomical profiles of treatment-resistance in patients with schizophrenia spectrum disorders (2020)
  • Author(s): Kim J, Plitman E, Iwata Y, Nakajima S, Mar W, Patel R, Chavez S, Chung JK, Caravaggio F, Chakravarty MM, Remington G, Gerretsen P, Graff-Guerrero A
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 99 Pages: 109839～109839
  • DOI: 10.1016/j.pnpbp.2019.109839
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early improvements of individual symptoms as a predictor of treatment response to asenapine in patients with schizophrenia (2020)
  • Author(s): Ogyu K, Noda Y, Yoshida K, Kurose S, Masuda F, Mimura Y, Nishida H, Plitman E, Tarumi R, Tsugawa S, Wada M, Miyazaki T, Uchida H, Graff-Guerrero A, Mimura M, Nakajima S
  • Journal Title: Neuropsychopharmacology Reports Volume: 40 Pages: 138～149
  • DOI: 10.1002/npr2.12103
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Approach‐oriented coping strategy level may be related to volume of the whole hippocampus in the elderly (2020)
  • Author(s): Kida H, Nakajima S, Shikimoto R, Ochi R, Noda Y, Tsugawa S, Fujii S, Takayama M, Mimura M, Niimura H
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Pages: 270～276
  • DOI: 10.1111/pcn.12981
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study (2020)
  • Author(s): Ochi R, Noda Y, Tsuchimoto S, Tarumi R, Honda S, Matsushita K, Tsugawa S, Plitman E, Masuda F, Ogyu K, Wada M, Miyazaki T, Fujii S, Chakravarty MM, Graff-Guerrero A, Uchida H, Mimura M, Nakajima S
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 100 Pages: 109871～109871
  • DOI: 10.1016/j.pnpbp.2020.109871
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gut microbiota and major depressive disorder: A systematic review and meta-analysis (2020)
  • Author(s): Sanada K, Nakajima S, Kurokawa S, et al
  • Journal Title: Journal of Affective Disorders Volume: 266 Pages: 1～13
  • DOI: 10.1016/j.jad.2020.01.102
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutamatergic neurometabolites and cortical thickness in treatment-resistant schizophrenia: Implications for glutamate-mediated excitotoxicity (2020)
  • Author(s): Shah P, Plitman E, Iwata Y, Kim J, Nakajima S, Chan N, Brown E, Caravaggio F, Torres E, Hahn M, Chakravarty M, Remington G, Gerretsen P, Graff-Guerrero A
  • Journal Title: Journal of Psychiatric Research Volume: 124 Pages: 151～158
  • DOI: 10.1016/j.jpsychires.2020.02.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment effects on neurometabolite levels in schizophrenia: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies (2020)
  • Author(s): Kubota M, Moriguchi S, Takahata K, Nakajima S, Horita N
  • Journal Title: Schizophrenia Research Volume: 222 Pages: 122～132
  • DOI: 10.1016/j.schres.2020.03.069
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacological management of behavioral disturbances in patients with Alzheimer’s disease (2020)
  • Author(s): Nagata T, Shinagawa S, Nakajima S, Noda Y, Mimura M
  • Journal Title: Expert Opinion on Pharmacotherapy Volume: 21 Pages: 1093～1102
  • DOI: 10.1080/14656566.2020.1745186
  • Peer Reviewed / Open Access
• [Journal Article] Treatment effects on neurometabolite levels in schizophrenia: A meta-analysis dataset of proton magnetic resonance spectroscopy (2020)
  • Author(s): Kubota M, Moriguchi S, Takahata K, Nakajima S, Horita N
  • Journal Title: Data in Brief Volume: 31 Pages: 105862～105862
  • DOI: 10.1016/j.dib.2020.105862
  • Peer Reviewed / Open Access
• [Journal Article] Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease (2020)
  • Author(s): Kobayashi N, Shinagawa S, Niimura H, Kida H, Nagata T, Tagai K, Shimada K, Oka N, Shikimoto R, Noda Y, Nakajima S, Mimura M, Shigeta M, Kondo K
  • Journal Title: Scientific Reports Volume: 10 Pages: 12217
  • DOI: 10.1038/s41598-020-69248-9
  • Peer Reviewed / Open Access
• [Journal Article] Resting-State Isolated Effective Connectivity of the Cingulate Cortex as a Neurophysiological Biomarker in Patients with Severe Treatment-Resistant Schizophrenia (2020)
  • Author(s): Wada M, Nakajima S, Tarumi R, Masuda F, Miyazaki T, Tsugawa S, Ogyu K, Honda S, Matsushita K, Kikuchi Y, Fujii S, Blumberger DM, Daskalakis ZJ, Mimura M, Noda Y
  • Journal Title: Journal of Personalized Medicine Volume: 10 Pages: 89～89
  • DOI: 10.3390/jpm10030089
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Frontostriatal Structural Connectivity and Striatal Glutamatergic Levels in Treatment-Resistant Schizophrenia: An Integrative Analysis of DTI and 1H-MRS (2020)
  • Author(s): Ochi R, Tarumi R, Noda Y, Tsugawa S, Plitman E, Wada M, Honda S, Matsushita K, Chakravarty MM, Graff-Guerrero A, Fujii S, Matsui M, Uchida H, Mimura M, Nakajima S
  • Journal Title: Schizophrenia Bulletin Open Volume: 1 Pages: sgaa057
  • DOI: 10.1093/schizbullopen/sgaa057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reduced Cortical Thickness in Schizophrenia and Schizotypal Disorder (2020)
  • Author(s): Takayanagi Y, Sasabayashi D, Takahashi T, Furuichi A, Kido M, Nishikawa Y, Nakamura M, Noguchi K, Suzuki M
  • Journal Title: Schizophrenia Bulletin Volume: 46 Pages: 387-394
  • DOI: 10.1093/schbul/sbz051
• [Journal Article] Increased brain gyrification in the schizophrenia spectrum (2020)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Nemoto K, Furuichi A, Kido M, Nishikawa Y, Nakamura M, Noguchi K, Suzuki M
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Pages: 70～76
  • DOI: 10.1111/pcn.12939
  • Peer Reviewed / Open Access
• [Journal Article] Pineal Gland Volume in Major Depressive and Bipolar Disorders (2020)
  • Author(s): Takahashi T, Sasabayashi D, Yucel M, Whittle S, Lorenzetti V, Walterfang M, Suzuki M, Pantelis C, Malhi GS, Allen NB
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 450
  • DOI: 10.3389/fpsyt.2020.00450
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gray Matter Changes in the Insular Cortex During the Course of the Schizophrenia Spectrum (2020)
  • Author(s): Takahashi T, Kido M, Sasabayashi D, Nakamura M, Furuichi A, Takayanagi Y, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 659
  • DOI: 10.3389/fpsyt.2020.00659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites (2020)
  • Author(s): Yamamoto M, Bagarinao E, Kushima I, Takahashi T, Sasabayashi D, Inada T, Suzuki M, Iidaka T, Ozaki N
  • Journal Title: PLOS ONE Volume: 15 Pages: e0239615
  • DOI: 10.1371/journal.pone.0239615
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structural MRI Study of the Planum Temporale in Individuals With an At-Risk Mental State Using Labeled Cortical Distance Mapping (2020)
  • Author(s): Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Omuro N, Katsura M, Nishiyama S, Nakamura M, Kido M, Furuichi A, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 593952
  • DOI: 10.3389/fpsyt.2020.593952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Features of Duration Mismatch Negativity Around the Onset of Overt Psychotic Disorders: A Longitudinal Study (2020)
  • Author(s): Tateno T, Higuchi Y, Nakajima S, Sasabayashi D, Nakamura M, Ueno M, Mizukami Y, Nishiyama S, Takahashi T, Sumiyoshi T, Suzuki M
  • Journal Title: Cerebral Cortex Volume: 31 Pages: 2416～2424
  • DOI: 10.1093/cercor/bhaa364
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 統合失調症の病態と最近の治療および就労について (2020)
  • Author(s): 平野羊嗣
  • Organizer: 勤労者こころの研究会
  • Invited
• [Presentation] Oscillatory Neurophysiological Biomarkers in Schizophrenia -Toward Translational Research- (2020)
  • Author(s): 平野羊嗣
  • Organizer: 第43回日本神経科学大会（基礎-臨床連携シンポジウム）
  • Invited
• [Presentation] 統合失調症の聴覚皮質体積減少とガンマオシレーション異常 (2020)
  • Author(s): 平野羊嗣
  • Organizer: 第42回日本生物学的精神医学会年会
• [Presentation] 精神現象の可視化：ガンマオシレーションを軸にした統合失調症の病態解明と治療 (2020)
  • Author(s): 平野羊嗣
  • Organizer: 第42回日本生物学的精神医学会年会（第7回日本生物学的精神医学会若手研究者育成プログラム最優秀奨励賞）
  • Invited
• [Presentation] トラベリングサブジェクト法と他の機種間差補正法の性能比較：国際脳ヒト脳MRI研究プロジェクトに向けて (2020)
  • Author(s): 小池進介
  • Organizer: 第48回日本磁気共鳴医学会大会
  • Invited
• [Presentation] 統合失調症スペクトラムにおける脳幹体積の検討 (2020)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋 努, 藤本岳, 古市厚志, 木戸幹雄, 中村美保子, 野口 京, 鈴木道雄
  • Organizer: 第42回日本生物学的精神医学会
• [Presentation] 精神病性障害における脳溝脳回形成の偏倚に関する研究 (2020)
  • Author(s): 笹林大樹
  • Organizer: 第42回日本生物学的精神医学会(第9回若手研究者育成プログラム)
• [Presentation] Relationship between cortical thickness and functional outcome in individuals at risk of psychosis. (2020)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Mizukami Y, Katagiri N, Sakuma A, Obara C, Koike S, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Noguchi K, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M
  • Organizer: The 7th Biennial Schizophrenia International Research Society Conference
  • Int'l Joint Research
• [Book] 精神疾患とその治療 (2020)
  • Author(s): 神庭重信（編集）平野羊嗣（分担）
  • Total Pages: 280
  • Publisher: 遠見書房
  • ISBN: 978-4-86616-072-6
• [Book] 精神科のくすりハンドブック 第3版 (2020)
  • Author(s): 樋口輝彦（編集）平野羊嗣（分担）
  • Total Pages: 681
  • Publisher: 総合医学社
  • ISBN: 978-4-88378-681-7
• [Remarks] Asian Consortium on MRI in Psychosis
  • URL: http://asia-mri-consortium.net/
• [Patent(Industrial Property Rights)] 脳波・脳磁図計測中に即時に活動源推定と連続Wavelet変換を行う方法 (2021)
  • Inventor(s): 平野羊嗣・中西翔一郎
  • Industrial Property Rights Holder: 平野羊嗣・中西翔一郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: K2020-0146