Toward reconstructing psychiatric disorders based on brain structure and function: International joint research project

2021 Fiscal Year Research-status Report

• Project/Area Number: 20KK0193
• Research Institution: Kyushu University
• Principal Investigator: 平野 羊嗣 九州大学, 大学病院, 講師 (90567497)
• Co-Investigator(Kenkyū-buntansha): 小池 進介 東京大学, 大学院総合文化研究科, 准教授 (10633167) ; 中島 振一郎 慶應義塾大学, 医学部(信濃町), 講師 (60383866) ; 笹林 大樹 富山大学, 学術研究部医学系, 助教 (80801414)
• Project Period (FY): 2020-10-27 – 2025-03-31
• Keywords: 精神疾患 / バイオタイプ / 脳構造 / 脳機能 / 国際共同研究

Outline of Annual Research Achievements

本国際協同研究は、精神疾患の共通性/異種性バイオタイプ開発を視野に入れた、アジア発の精神疾患の脳構造（ACMP）および脳機能（ACEP）研究の拠点構築を目標とする。本研究により『脳構造と脳機能から精神疾患を再定義』することで、精神疾患全体の本質的な理解と治療法の再構築を目指す。参画施設が大学病院であるため、今年度もCOVID-19感染拡大による多大な影響を受けたが、各々の指針に従いながら、随時実験を再開し、WEB会議やWEB上でのデータ収集とその解析を行うことで、ある程度予定していた研究を進めることができた。各自の実績は以下の通り。
＜平野＞海外の脳波関連の共同研究施設とはWEB会議で連携しつつ、臨床脳波を用いた国内の共同研究(7施設)に関する統括およびデータ収集、解析パイプラインの構築を完成させた。また、本研究に関わる論文15本を国際専門誌に投稿し受理された。
＜小池＞ACMPはアジア諸国との共同研究であるためCOVID-19により遅延しているが、ようやく参画7施設の脳構造データと臨床データを取りまとめ、現在前処理を一括して行っている。2022年度にデータ配布を開始する予定である。また、WEBシンポジウム等積極的に行い、本研究に関わる論文20本を国際専門誌に投稿し受理された。
＜中島＞ACEPにおいて、90名の被験者のデータの収集を行い、解析パイプラインの構築を確立し、最終解析を終えた。治療抵抗性統合失調症におけるASSRの異常を明らかにし、発表のために執筆の段階に進んでいる。また、本研究に関わる論文26本を国際専門誌に投稿し受理された。
＜笹林＞ACMP内の2つの研究計画に関する臨床データを各参画施設から収集し、データの統合を行った。今年度より自施設もACEPに参画し、データの収集と解析パイプラインの構築を開始した。また、本研究に関わる論文13本を国際専門誌に投稿し受理された。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

今年度もCOVID-19感染症拡大の影響で一時的に究活動を中断せざるを得なかったが、各参画施設や病院の指針に従いながら、随時実験を再開し、WEB会議やWEB上でのデータの共有も並行することによりデータ収集とその解析を行うことで、予定していた研究を進めることができた。海外の脳波・MRI/MRS関連の共同研究施設ともWEB会議で連携しつつ、臨床脳波・MRI・fMRI・MRSといったマルチモダリティ解析のための国内外の共同研究に関する構築ならびに、データ収集、解析パイプラインの構築を完成させることができた。また、今年度は、本研究に関わる論文74本(平野:15本、小池:20本、中島:26本、笹林:13本)を多数のハイインパクトジャーナルを含め、多くの国際専門誌に投稿・受理されており、十分成果を出すことが出来たと考える。

Strategy for Future Research Activity

2022年4月時点においても、COVID-19感染症に関する本協同研究計画に対する影響は続いており、各研究参画機関で一時的な実験や計測の中断もしくは遅延が発生している。また、渡航制限により、海外のみならず国内の移動も制限されており、データ共有、人的交流、指導および人材育成に対する影響も以前見受けられる。今後は、感染拡大状況を注視しつつ、各参画施設の指針に従いながら、随時実験を再開し、さらなるデータ収集とその解析、また既存データの集積と統合解析も合わせて行っていく。さらに、国内外の脳波・MRI/MRS関連の共同研究施設とは引き続きWEB会議等で連携しつつ効率的に研究を推進していく。渡航が可能になった場合は直接、ハーバート大学やトロント大学などのコラボ先の研究施設に赴き、新たな技術の習得、データ共有、解析手法の習得を進める予定である。

Causes of Carryover

2021年度も、COVID-19感染症拡大の影響により、予定していた本国際共同研究に関わる国内外の出張ができず、加えて本共同研究の殆どの参画施設が大学病院であるため、研究活動そのものを一時的に中断せざるを得なかったため、その他付随して発生する費用の支出が予定より見込めず、次年度に繰り越すこととした。今後は、感染拡大状況を注視しつつ、各参画施設や病院の指針に従いながら、随時実験を再開し、データ収集とその解析、また既存データの集積と解析も合わせて行っていく。さらに、国内外の共同研究施設とは引き続きWEB会議等で連携しつつ研究を推進していく。なお、渡航が可能になった場合は直接、ハーバート大学やトロント大学などのコラボ先の研究施設に赴き、新たな技術の習得、データ共有、解析手法の習得を進める予定である。

Research Products

• [Int'l Joint Research] Harvard Medical School/Children's Hospital of Philadelphia/Johns Hopkins University(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Harvard Medical School/Children's Hospital of Philadelphia/Johns Hopkins University
• [Int'l Joint Research] University of Toronto/McGill University/University Ottawa(カナダ)
  • Country Name: CANADA
  • Counterpart Institution: University of Toronto/McGill University/University Ottawa
• [Int'l Joint Research] The University of Melbourne/Melbourne Health/UNSW Sydney(オーストラリア)
  • Country Name: AUSTRALIA
  • Counterpart Institution: The University of Melbourne/Melbourne Health/UNSW Sydney
• [Int'l Joint Research] National Taiwan University Hospital/National Cheng Kung University Hospital/Peking University(中国)
  • Country Name: CHINA
  • Counterpart Institution: National Taiwan University Hospital/National Cheng Kung University Hospital/Peking University
  • # of Other Institutions: 1
• [Int'l Joint Research] Seoul National University/Chonbuk National University Hospital/CHA Bundang Medical Center(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: Seoul National University/Chonbuk National University Hospital/CHA Bundang Medical Center
• [Int'l Joint Research]
  • # of Other Countries: 2
• [Journal Article] Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, Koike S, Sasabayashi D, Katayama H, Plitman E, Ohi K, Ueno F, Caravaggio F, Koizumi T, Gerretsen P, Suzuki T, Uchida H, Mimura M, Remington G, Grace AA, Graff-Guerrero A, Nakajima S
  • Journal Title: Molecular Psychiatry Volume: 27 Pages: 2950-2967
  • DOI: 10.1038/s41380-022-01572-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools (2022)
  • Author(s): Koike S, Uematsu A, Sasabayashi D, Maikusa N, Takahashi T, Ohi K, Nakajima S, Noda Y, Hirano Y
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 21 Pages: 539-552
  • DOI: 10.2463/mrms.rev.2021-0050
  • Peer Reviewed / Open Access
• [Journal Article] Toward Recovery in Schizophrenia: Current Concepts, Findings, and Future Research Directions (2022)
  • Author(s): Onitsuka T, Hirano Y, Nakazawa T, Ichihashi K, Miura K, Inada K, Mitoma R, Yasui-Furukori N, Hashimoto R.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Pages: 282-291
  • DOI: 10.1111/pcn.13342
  • Peer Reviewed / Open Access
• [Journal Article] Volume reduction of the dorsal lateral prefrontal cortex prior to the onset of frank psychosis in individuals with an at-risk mental state. (2022)
  • Author(s): Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Ohmuro N, Katsura M, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
  • Journal Title: Cerebral Cortex Volume: 32 Pages: 2245-2253
  • DOI: 10.1093/cercor/bhab353
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Application of a machine learning algorithm for structural brain images in chronic schizophrenia to earlier clinical stages of psychosis and autism spectrum disorder: A multi-protocol imaging dataset study (2022)
  • Author(s): Zhu Y, Nakatani H, Yassin W, Maikusa N, Okada N, Kunimatsu A, Abe O, Kuwabara H, Yamasue H, Kasai K, Okanoya K, Koike S
  • Journal Title: Schizophrenia Bulletin Volume: 48 Pages: 563-574
  • DOI: 10.1093/schbul/sbac030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Shared functional impairment in the prefrontal cortex affects symptom severity across psychiatric disorders (2022)
  • Author(s): Koike S, Sakakibara E, Satomura Y, Sakurada H, Yamagishi M, Matsuoka J, Okada N, Kasai K
  • Journal Title: Psychological Medicine Volume: 52 Pages: 2661-2670
  • DOI: 10.1017/S0033291720004742
  • Peer Reviewed
• [Journal Article] AMPA receptors in schizophrenia: A systematic review of postmortem studies on receptor subunit expression and binding (2022)
  • Author(s): Yonezawa K, Tani H, Nakajima S, Nagai N, Koizumi T, Miyazaki T, Mimura M, Takahashi T, Uchida H
  • Journal Title: Schizophrenia Research Volume: 243 Pages: 98-109
  • DOI: 10.1016/j.schres.2022.02.033
  • Peer Reviewed
• [Journal Article] Decision tree classification of cognitive functions with D(2) receptor occupancy and illness severity in late-life schizophrenia (2022)
  • Author(s): Kusudo K, Ochi R, Nakajima S, Suzuki T, Mamo D, Caravaggio F, Mar W, Gerretsen P, Mimura M, Pollock BG, Mulsant BH, Graff-Guerrero A, Rajji TK, Uchida H.
  • Journal Title: Schizophrenia Research Volume: 241 Pages: 113-115
  • DOI: 10.1016/j.schres.2022.01.044
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients (2022)
  • Author(s): Ismail M, Straubinger T, Uchida H, Graff-Guerrero A, Nakajima S, Suzuki T, Caravaggio F, Gerretsen P, Mamo D, Mulsant BH, Pollock BG, Bies R.
  • Journal Title: British Journal of Clinical Pharmacology Volume: 88 Pages: 3341-3350
  • DOI: 10.1111/bcp.15260
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The effects of acute dopamine depletion on resting-state functional connectivity in healthy humans (2022)
  • Author(s): Caravaggio F, Barnett AJ, Nakajima S, Iwata Y, Kim J, Borlido C, Mar W, Gerretsen P, Remington G, Graff-Guerrero A.
  • Journal Title: European Neuropsychopharmacology Volume: 57 Pages: 39-49
  • DOI: 10.1016/j.euroneuro.2022.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroimaging-derived brain age is associated with life satisfaction in cognitively unimpaired elderly: A community-based study (2022)
  • Author(s): Sone D, Beheshti I, Shinagawa S, Niimura H, Kobayashi N, Kida H, Shikimoto R, Noda Y, Nakajima S, Bun S, Mimura M, Shigeta M.
  • Journal Title: Translational Psychiatry Volume: 12 Pages: 25
  • DOI: 10.1038/s41398-022-01793-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Investigating structural subdivisions of the anterior cingulate cortex in schizophrenia, with implications for treatment resistance and glutamatergic levels (2022)
  • Author(s): Ochi R, Plitman E, Patel R, Tarumi R, Iwata Y, Tsugawa S, Kim J, Honda S, Noda Y, Uchida H, Devenyi GA, Mimura M, Graff-Guerrero A, Chakravarty MM, Nakajima S.
  • Journal Title: Journal of Psychiatry and Neuroscience Volume: 47 Pages: E1-E10
  • DOI: 10.1503/jpn.210113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis (2022)
  • Author(s): Ueno F, Iwata Y, Nakajima S, Caravaggio F, Rubio JM, Horga G, Cassidy CM, Torres-Carmona E, de Luca V, Tsugawa S, Honda S, Moriguchi S, Noda Y, Gerretsen P, Graff-Guerrero A.
  • Journal Title: Neuroscience & Biobehavioral Reviews Volume: 132 Pages: 1205-1213
  • DOI: 10.1016/j.neubiorev.2021.10.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of (1)H-magnetic resonance spectroscopy studies (2022)
  • Author(s): Nakahara T, Tsugawa S, Noda Y, Ueno F, Honda S, Kinjo M, Segawa H, Hondo N, Mori Y, Watanabe H, Nakahara K, Yoshida K, Wada M, Tarumi R, Iwata Y, Plitman E, Moriguchi S, de la Fuente-Sandoval C, Uchida H, Mimura M, Graff-Guerrero A, Nakajima S.
  • Journal Title: Molecular Psychiatry Volume: 27 Pages: 44-757
  • DOI: 10.1038/s41380-021-01297-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multi-modal imaging of the auditory-larynx motor network for voicing perception (2022)
  • Author(s): Tamura S, Hirose H, Mitsudo T, Hoaki N, Nakamura I, Onitsuka T, Hirano Y
  • Journal Title: NeuroImage Volume: 251 Pages: 118981-118981
  • DOI: 10.1016/j.neuroimage.2022
  • Peer Reviewed / Open Access
• [Journal Article] Trends in Big Data Analyses by Multicenter Collaborative Translational Research in Psychiatry (2022)
  • Author(s): Onitsuka T, Hirano Y, Nemoto K, Hashimoto N, Kushima I, Koshiyama D, Koeda M, Takahashi T, Noda Y, Matsumoto J, Miura K, Nakazawa T, Hikida T, Kasai K, Ozaki N, Hashimoto R
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Pages: 14-Jan
  • DOI: 10.1111/pcn.13311
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial (2022)
  • Author(s): Yamasue H, Kojima M,…Hirano Y, Onitsuka T, Kosaka H, Okada T.
  • Journal Title: Brain Volume: 145 Pages: 490-499
  • DOI: 10.1093/brain/awab291
  • Peer Reviewed / Open Access
• [Journal Article] Transdiagnostic Comparisons of Intellectual Abilities and Work Outcome in Patients with Mental Disorders: A Multicentre Study (2022)
  • Author(s): Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yuka Yasuda, Yota Uno, Junichi Takahashi, Kentaro Morita, Asuka Katsuki, Maeri Yamamoto, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, et al
  • Journal Title: BJPsych Open Volume: in press Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Nutrient infusion evoked magnetic resonance imaging signal in the human hypothalamus (2022)
  • Author(s): Nakamura Y, Takahashi M, Inoue Y, Yanagimoto S, Okanoya K, Koike S
  • Journal Title: Nutr Neurosci Volume: in press Pages: -
  • DOI: 10.1080/1028415X.2021.1983102
  • Peer Reviewed
• [Journal Article] Pharmacotherapeutic combinations for the treatment of Alzheimer's disease (2022)
  • Author(s): Nagata T, Shinagawa S, Nakajima S, Noda Y, Mimura M.
  • Journal Title: Expert Opinion on Pharmacotherapy Volume: in press Pages: -
  • DOI: 10.1080/14656566.2022.2042514
  • Peer Reviewed
• [Journal Article] DopaminergicDysfunction and Excitatory/Inhibitory Imbalance in Treatment-ResistantSchizophrenia and Novel Neuromodulatory Treatment. (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, Koike S,SasabayashiD, Katayama H, Plitman E, Ohi K, Ueno F, Caravaggio F,Koizumi T, Gerretsen P, Suzuki T, Uchida H, M殕ler DJ, Mimura M,Remington G, Grace AA, Graff-Guerrero A,Nakajima S.
  • Journal Title: Molecular Psychiatry Volume: in press Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Influence of external natural environment including sunshineexposure on public mental health: A systematic review. (2022)
  • Author(s): Taniguchi K, Takano M, Tobari Y, Hayano M,Nakajima S, Mimura M, TsubotaK, Noda Y*.
  • Journal Title: Psychiatry International Volume: in press Pages: -
  • Peer Reviewed
• [Journal Article] Reduced striatal dopamine D 2/3 receptor availability inobsessive-compulsive disorder: A meta-analysis of [ 11 C]-raclopride and[ 123 I]-IBZM studies. (2022)
  • Author(s): Caravaggio F, Porco N, Iwata Y,Nakajima S, GerretsenP, Remington G,Graff-Guerrero A.
  • Journal Title: Journal of Obsessive-Compulsive and RelatedDisorders. Volume: in press Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Frontostriatal Structural Connectivity andStriatal Glutamatergic Levels in Treatment-Resistant Schizophrenia: AnIntegrative Analysis of DTI and 1H-MRS. (2022)
  • Author(s): Ochi R, Tarumi R (co-first), Noda Y*, Tsugawa S, Plitman E, Wada M, HondaS, Matsushita K, Chakravarty MM, Graff-Guerrero A, Fujii S, Matsui M,Uchida H, Mimura M,Nakajima S.
  • Journal Title: Schizophrenia Bulletin Open Volume: in press Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Current MEG Research in Psychiatry (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 647085
  • DOI: 10.3389/fpsyt.2021.647085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study (2021)
  • Author(s): Jinya Sato, Yoji Hirano*, Noriaki Hirakawa, Junichi Takahashi, Naoya Oribe, Hironori Kuga, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao, Toshiaki Onitsuka
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 121-121
  • DOI: 10.3390/jpm11020121
  • Peer Reviewed / Open Access
• [Journal Article] Effects of age and sex on eye movement characteristics (2021)
  • Author(s): Junichi Takahashi, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Seiko Miyata, Kosuke Okazaki, Junya Matsumoto, Naomi Hasegawa, Yoji Hirano, Hidenaga Yamamori, Yuka Yasuda, Manabu Makinodan, Kiyoto Kasai, Norio Ozaki, Toshiaki Onitsuka, Ryota Hashimoto
  • Journal Title: Neuropsychopharmacology Reports Volume: 41 Pages: 152-158
  • DOI: 10.1002/npr2.12163
  • Peer Reviewed / Open Access
• [Journal Article] Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review (2021)
  • Author(s): Alexandra Wolf, Kazuo Ueda, Yoji Hirano*
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Pages: 82-100
  • DOI: 10.1111/pcn.13188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent Findings on Neurofeedback Training for Auditory Hallucinations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Shunsuke Tamura
  • Journal Title: Current Opinion in Psychiatry Volume: 34 Pages: 245-252
  • DOI: 10.1097/yco.000000000000
  • Peer Reviewed / Open Access
• [Journal Article] Eye Movement Abnormalities in Major Depressive Disorder (2021)
  • Author(s): Junichi Takahashi, Yoji Hirano*, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Ryota Hashimoto, Toshiaki Onitsuka
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 673443
  • DOI: 10.3389/fpsyt.2021.673443
  • Peer Reviewed / Open Access
• [Journal Article] Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder (2021)
  • Author(s): Ryo Mitoma, Shunsuke Tamura, Hiroshi Tateishi, Takako Mitsudo, Ichiro Tanabe, Akira Monji, Yoji Hirano*
  • Journal Title: Journal of Affective Disorders Reports Volume: 7 Pages: 100277-100277
  • DOI: 10.1016/j.jadr.2021.100277
  • Peer Reviewed / Open Access
• [Journal Article] Current Findings and Perspectives on Aberrant Neural Oscillations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Pages: 358-368
  • DOI: 10.1111/pcn.13300
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of travelling-subject and ComBat harmonization methods for assessing structural brain characteristics (2021)
  • Author(s): Maikusa N, Zhu Y, Uematsu A, Yamashita A, Saotome K, Okada N, Kasai K, Okanoya K, Yamashita O, Tanaka SC, Koike S
  • Journal Title: Hum Brain Mapp Volume: 42 Pages: 5278-87
  • DOI: 10.1002/hbm.25615
  • Peer Reviewed / Open Access
• [Journal Article] Volumetric differences in gray and white matter of cerebellar Crus I/II across the different clinical stages of schizophrenia (2021)
  • Author(s): Morimoto C, Uematsu A, Nakatani H, Takano Y, Iwashiro N, Abe O, Yamasue H, Kasai K, Koike S
  • Journal Title: Psychiatry Clin Neurosci Volume: 75 Pages: 256-64
  • DOI: 10.1111/pcn.13277
  • Peer Reviewed
• [Journal Article] Dietary restraint related to body weight maintenance and neural processing in value-coding areas in adolescents (2021)
  • Author(s): Nakamura Y, Ando S, Yamasaki S, Okada N, Nishida A, Kasai K, Tanaka S, Nakatani H, Koike S
  • Journal Title: J Nutr Volume: 151 Pages: 2059-67
  • DOI: 10.1093/jn/nxab068
  • Peer Reviewed
• [Journal Article] Structural MRI measures associated with psychosis onset in individuals at clinical high risk for developing psychosis: An ENIGMA Working Group mega-analysis (2021)
  • Author(s): ENIGMA Clinical High Risk for Psychosis Working Group; Jalbrzikowski M, Hayes RA, Wood SJ, et al
  • Journal Title: JAMA Psychiatry Volume: 78 Pages: 753-66
  • DOI: 10.1001/jamapsychiatry.2021.0638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intergenerational transmission of the patterns of functional and structural brain networks (2021)
  • Author(s): Takagi Y, Okada N, Ando S, Yahata N, Morita K, Koshiyama D, Kawakami S, Sawada K, Koike S, Endo K, Yamasaki S, Nishida A, Kasai K, Tanaka SC
  • Journal Title: iScience Volume: 24 Pages: 102708
  • DOI: 10.1016/j.isci.2021.102708
  • Peer Reviewed / Open Access
• [Journal Article] Unique morphometric features of the cerebellum and cerebellocerebral structural correlation between autism spectrum disorder and schizophrenia (2021)
  • Author(s): Morimoto C, Nakamura Y, Kuwabara H, Abe O, Kasai K, Yamasue H, Koike S
  • Journal Title: Biol Psychiatry: Global Open Science Volume: 1 Pages: 219-28
  • DOI: 10.1016/j.bpsgos.2021.05.010
  • Peer Reviewed / Open Access
• [Journal Article] Neurocognitive deficits mediate the relationship between structural abnormalities and clinical outcomes in individuals with ultra-high risk for psychosis: A multi-modal neuroimaging and longitudinal neurocognitive study (2021)
  • Author(s): Koike S, Fujioka M, Takano Y, Iwashiro N, Satomura Y, Nagai T, Koshiyama D, Tada M, Natsubori T, Okada N, Abe O, Kirihara K, Yamasue H, Suga M, Kasai K
  • Journal Title: Schizophr Bull Open Volume: 2 Pages: sgab027
  • DOI: 10.1093/schizbullopen/sgab027
  • Peer Reviewed / Open Access
• [Journal Article] Cross-scanner reproducibility and harmonization of a diffusion MRI structural brain network: A traveling subject study of multi-b acquisition (2021)
  • Author(s): Kurokawa R, Kamiya K, Koike S, Nakaya M, Uematsu A, Tanaka SC, Kamagata K, Okada N, Morita K, Kasai K, Abe O
  • Journal Title: NeuroImage Volume: 245 Pages: 118675
  • DOI: 10.1016/j.neuroimage.2021.118675
  • Peer Reviewed / Open Access
• [Journal Article] Brain/MINDS?Beyond?Human?Brain?MRI?Project:?A?protocol?for?multi-level?harmonization?across?brain?disorders?throughout?the?lifespan (2021)
  • Author(s): Koike S, Tanaka SC, Okada T, et al
  • Journal Title: NeuroImage Clin Volume: 30 Pages: 102600
  • DOI: 10.1016/j.nicl.2021.102600
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal bidirectional relationships between maternal depressive/anxious symptoms and children’s tic frequency in early adolescence (2021)
  • Author(s): Yagi T, Ando S, Usami S, Yamasaki S, Morita M, Kiyono T, Hayashi N, Endo K, Iijima Y, Morimoto Y, Kanata S, Fujikawa S, Koike S, Kano Y, Hiraiwa-Hasegawa M, Nishida A, Kasai K
  • Journal Title: Front Psychiatry Volume: 16 Pages: 767571
  • DOI: 10.3389/fpsyt.2021.767571
  • Peer Reviewed / Open Access
• [Journal Article] Association of disinhibited eating and trait of impulsivity with insula and amygdala responses to palatable liquid consumption (2021)
  • Author(s): Nakamura Y, Koike S
  • Journal Title: Front System Neurosci Volume: 15 Pages: 647143
  • DOI: 10.3389/fnsys.2021.647143
  • Peer Reviewed / Open Access
• [Journal Article] AKR1A1 variant associated with schizophrenia causes exon skipping, leading to loss of enzymatic activity (2021)
  • Author(s): Iino K, Toriumi K, Agarie R, Miyashita M, Suzuki K, Horiuchi Y, Niizato K, Oshima K, Imai A, Nagase Y, Kushima I, Koike S, Ikegame T, Jinde S, Nagata E, Washizuka S, Miyata T, Takizawa S, Hashimoto R, Kasai K, Ozaki N, Itokawa M, Arai M
  • Journal Title: Front Genet Volume: 12 Pages: 762999
  • DOI: 10.3389/fgene.2021.762999
  • Peer Reviewed / Open Access
• [Journal Article] Abnormality of resting-state functional connectivity in major depressive disorder: A study with whole-head near-infrared spectroscopy (2021)
  • Author(s): Sakakibara E, Satomura Y, Matsuoka J, Koike S, Okada N, Sakurada H, Yamagishi M, Kawakami N, Kasai K
  • Journal Title: Front Psychiatry Volume: 12 Pages: 664859
  • DOI: 10.3389/fpsyt.2021.664859
  • Peer Reviewed / Open Access
• [Journal Article] Birth order and prosociality in the early adolescent brain (2021)
  • Author(s): Okada N, Yamamoto Y, Yahata N, Morita S, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Yokoyama C, Kasai K
  • Journal Title: Sci Rep Volume: 11 Pages: 21806
  • DOI: 10.1038/s41598-021-01146-0
  • Peer Reviewed / Open Access
• [Journal Article] Reduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor one-year functional outcomes (2021)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Nishiyama S, Mizukami Y, Katagiri N, Tsujino N, Nemoto T, Sakuma A, Katsura M, Ohmuro N, Okada N, Tada M, Suga M, Maikusa N, Koike S, Furuichi A, Kido M, Noguchi K, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 396
  • DOI: 10.1038/s41398-021-01516-2
  • Peer Reviewed / Open Access
• [Journal Article] Development of metacognition in adolescence: The congruency-based metacognition scale (2021)
  • Author(s): Kawata KH, Ueno Y, Hashimoto R, Yoshino S, Ohta K, Nishida A, Ando S, Nakatani H, Kasai K, Koike S
  • Journal Title: Front Psychol Volume: 11 Pages: 565231
  • DOI: 10.3389/fpsyg.2020.565231
  • Peer Reviewed / Open Access
• [Journal Article] Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis (2021)
  • Author(s): Koike S, Fujioka M, Satomura Y, Koshiyama D, Tada M, Sakakibara E, Okada N, Takano Y, Iwashiro N, Natsubori T, Zhu Y, Abe O, Kirihara K, Yamasue H, Kasai K
  • Journal Title: npj Schizophr Volume: 7 Pages: 56
  • DOI: 10.1038/s41537-021-00186-9
  • Peer Reviewed / Open Access
• [Journal Article] Features of duration mismatch negativity around the onset of overt psychotic disorders: A longitudinal study. (2021)
  • Author(s): Tateno T, Higuchi Y, Nakajima S, Sasabayashi D, Nakamura M, Ueno M, Mizukami Y, Nishiyama S, Takahashi T, Sumiyoshi T, Suzuki M.
  • Journal Title: Cerebral Cortex Volume: 31 Pages: 2416~2424
  • DOI: 10.1093/cercor/bhaa364
  • Peer Reviewed
• [Journal Article] Altered Heschl’s gyrus duplication pattern in first-episode schizophrenia. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Pham TV, Kobayashi H, Noguchi K, Suzuki M.
  • Journal Title: Schizophrenia Research Volume: 237 Pages: 174-181
  • DOI: 10.1016/j.schres.2021.09.011
  • Peer Reviewed
• [Journal Article] Potential contribution of pineal atropy and pineal cysts toward vulnerability and clinical characteristics of psychosis. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M.
  • Journal Title: NeuroImage: Clinical Volume: 32 Pages: 102805
  • DOI: 10.1016/j.nicl.2021.102805
  • Peer Reviewed / Open Access
• [Journal Article] Heschl’s gyrus duplication pattern in individuals at risk of developing psychosis and patients with schizophrenia. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Nishiyama S, Furuichi A, Kido M, Pham TV, Kobayashi H, Noguchi K, Suzuki M.
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 15 Pages: 647069
  • DOI: 10.3389/fnbeh.2021.647069
  • Peer Reviewed / Open Access
• [Journal Article] Increased Heschl’s gyrus duplication in schizophrenia spectrum disorders: A cross-sectional MRI study. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Pham TV, Kobayashi H, Noguchi K, Suzuki M.
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 40
  • DOI: 10.3390/jpm11010040
  • Peer Reviewed / Open Access
• [Journal Article] Reduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor 1-year functional outcomes. (2021)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Nishiyama S, Mizukami Y, Katagiri N, Tsujino N, Nemoto T, Sakuma A, Katsura M, Omuro N, Okada N, Tada M, Suga M, Koike S, Nakamura M, Furuichi A, Kido M, Noguchi K, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M.
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 396
  • DOI: 10.1038/s41398-021-01516-2
  • Peer Reviewed / Open Access
• [Journal Article] Reduced hippocampal subfield volume in schizophrenia and clinical high-risk state for psychosis. (2021)
  • Author(s): Sasabayashi D, Yoshimura R, Takahashi T, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Nakamura M, Noguchi K, Suzuki M.
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 642048
  • DOI: 10.3389/fpsyt.2021.642048
  • Peer Reviewed / Open Access
• [Journal Article] Anomalous brain gyrification patterns in major psychiatric disorders: A systematic review and transdiagnostic integration. (2021)
  • Author(s): Sasabayashi D, Takahashi T, Takayanagi Y, Suzuki M.
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 176
  • DOI: 10.1038/s41398-021-01297-8
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal changes in brain gyrification in schizophrenia spectrum disorders. (2021)
  • Author(s): Pham TV, Sasabayashi D, Takahashi T, Takayanagi Y, Kubota M, Furuichi A, Kido M, Noguchi K, Suzuki M.
  • Journal Title: Frontiers in Aging Neuroscience Volume: 13 Pages: 752575
  • DOI: 10.3389/fnagi.2021.752575
  • Peer Reviewed / Open Access
• [Journal Article] Duration mismatch negativity predicts remission in first-episode schizophrenia patients. (2021)
  • Author(s): Nakajima S, Higuchi Y, Tateno T, Sasabayashi D, Mizukami Y, Nishiyama S, Takahashi T, Suzuki M.
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 777378
  • DOI: 10.3389/fpsyt.2021.777378
  • Peer Reviewed / Open Access
• [Journal Article] Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia. (2021)
  • Author(s): Higuchi Y, Sumiyoshi T, Tateno T, Nakajima S, Sasabayashi D, Nishiyama S, Mizukami Y, Takahashi T, Suzuki M.
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 327
  • DOI: 10.3390/jpm11050327
  • Peer Reviewed / Open Access
• [Journal Article] Development of an Advanced Sham Coil for Transcranial Magnetic Stimulation and Examination of Its Specifications (2021)
  • Author(s): Takano M, Havlicek J, Phillips D, Nakajima S, Mimura M, Noda Y.
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 1058
  • DOI: 10.3390/jpm11111058
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dimensional distribution of cortical abnormality across antipsychotics treatment-resistant and responsive schizophrenia (2021)
  • Author(s): Itahashi T, Noda Y, Iwata Y, Tarumi R, Tsugawa S, Plitman E, Honda S, Caravaggio F, Kim J, Matsushita K, Gerretsen P, Uchida H, Remington G, Mimura M, Aoki YY, Graff-Guerrero A, Nakajima S.
  • Journal Title: Neuroimage Clinical Volume: 32 Pages: 102852
  • DOI: 10.1016/j.nicl.2021.102852
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Insights of neurophysiology on unconscious state using combined transcranial magnetic stimulation and electroencephalography: A systematic review (2021)
  • Author(s): Arai N, Nakanishi T, Nakajima S, Li X, Wada M, Daskalakis ZJ, Goodman MS, Blumberger DM, Mimura M, Noda Y.
  • Journal Title: Neuroscience & Biobehavioral Reviews Volume: 131 Pages: 293-312
  • DOI: 10.1016/j.neubiorev.2021.09.029
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between resilience and cortical thickness in the posterior cingulate cortex and the temporal pole in Japanese older people: A population-based cross-sectional study (2021)
  • Author(s): Shikimoto R, Noda Y, Kida H, Nakajima S, Tsugawa S, Mimura Y, Ochi R, Takayama M, Niimura H, Mimura M.
  • Journal Title: Journal of Psychiatric Research Volume: 142 Pages: 89-100
  • DOI: 10.1016/j.jpsychires.2021.07.026
  • Peer Reviewed
• [Journal Article] Frequency drift in MR spectroscopy at 3T (2021)
  • Author(s): Hui SCN, Mikkelsen M, Nakajima S, et al
  • Journal Title: Neuroimage Volume: 241 Pages: 118430
  • DOI: 10.1016/j.neuroimage.2021.118430
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Photobiological Neuromodulation of Resting-State EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals (2021)
  • Author(s): Noda Y, Takano M, Hayano M, Li X, Wada M, Nakajima S, Mimura M, Kondo S, Tsubota K.
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 557
  • DOI: 10.3390/jpm11060557
  • Peer Reviewed / Open Access
• [Journal Article] TMS-EEG Research to Elucidate the Pathophysiological Neural Bases in Patients with Schizophrenia: A Systematic Review (2021)
  • Author(s): Li X, Honda S, Nakajima S, Wada M, Yoshida K, Daskalakis ZJ, Mimura M, Noda Y.
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 388
  • DOI: 10.3390/jpm11050388
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutathione Levels and Glutathione-Glutamate Correlation in Patients With Treatment-Resistant Schizophrenia (2021)
  • Author(s): Iwata Y, Nakajima S, Plitman E, Truong P, Bani-Fatemi A, Caravaggio F, Kim J, Shah P, Mar W, Chavez S, Remington G, Gerretsen P, De Luca V, Sailasuta N, Graff-Guerrero A.
  • Journal Title: Schizophrenia Bulletin Open Volume: 2 Pages: sgab006
  • DOI: 10.1093/schizbullopen/sgab006
  • Peer Reviewed / Open Access
• [Journal Article] Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study (2021)
  • Author(s): Ohi K, Ochi R, Noda Y, Wada M, Sugiyama S, Nishi A, Shioiri T, Mimura M, Nakajima S.
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 187
  • DOI: 10.1038/s41398-021-01308-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Measuring amphetamine-induced dopamine release in humans: A comparative meta-analysis of [(11) C]-raclopride and [(11) C]-(+)-PHNO studies (2021)
  • Author(s): Caravaggio F, Porco N, Kim J, Torres-Carmona E, Brown E, Iwata Y, Nakajima S, Gerretsen P, Remington G, Graff-Guerrero A.
  • Journal Title: Synapse Volume: 75 Pages: e22195
  • DOI: 10.1002/syn.22195
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis (2021)
  • Author(s): Mimura Y, Nishida H, Nakajima S, Tsugawa S, Morita S, Yoshida K, Tarumi R, Ogyu K, Wada M, Kurose S, Miyazaki T, Blumberger DM, Daskalakis ZJ, Chen R, Mimura M, Noda Y.
  • Journal Title: Neuroscience & Biobehavioral Reviews Volume: 121 Pages: 47-59
  • DOI: 10.1016/j.neubiorev.2020.12.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis (2021)
  • Author(s): Kinjo M, Wada M, Nakajima S, Tsugawa S, Nakahara T, Blumberger DM, Mimura M, Noda Y.
  • Journal Title: Psychological Medicine Volume: 51 Pages: 1-10
  • DOI: 10.1017/S0033291720004729
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Spontaneous and Evoked Neural Oscillation Abnormalities in Schizophrenia (2021)
  • Author(s): Hirano Y (Symposium Co-chair)
  • Organizer: 9th European Conference on Schizophrenia Research
  • Int'l Joint Research / Invited
• [Presentation] Dynamic Neural Activity Changes After Transcranial Magnetic Stimulation Treatment in Patients with Major Depressive Disorder (2021)
  • Author(s): Hirano Y, Mitoma R, Tamura S, Tateishi H, Monji A
  • Organizer: The 2021 Society of Biological Psychiatry Annual Meeting
  • Int'l Joint Research
• [Presentation] Increased Theta/Alpha Source Activity and Default Mode Network Connectivity in Schizophrenia During Eyes-Closed Rest (2021)
  • Author(s): Nakhnikian A, Oribe N, Hirano S, Hirano Y, Levin M, Spencer K
  • Organizer: The 2021 Society of Biological Psychiatry Annual MeetingHirano Y, Mitsudo T, Tamura S
  • Int'l Joint Research
• [Presentation] Attention to Sound Stimuli Modulates Gamma Oscillation: Towards Neurofeedback Training (2021)
  • Author(s): Hirano Y, Mitsudo T, Tamura S
  • Organizer: The 2021 Congress of The Schizophrenia International Research Society,
  • Int'l Joint Research / Invited
• [Presentation] Eye-Movement Abnormalities among Patients with Schizophrenia (2021)
  • Author(s): Wolf A, Hirano Y
  • Organizer: 43rd European Conference on Visual Perception
  • Int'l Joint Research
• [Presentation] 精神現象の可視化 ガンマオシレーションを軸にした 統合失調症の病態解明と治療 (2021)
  • Author(s): 平野羊嗣
  • Organizer: 第7回 JSBP 若手研究者育成プログラム最優秀奨励賞受賞講演
  • Invited
• [Presentation] Translatable neurophysiological biomarkers in patients with schizophrenia (2021)
  • Author(s): Hirano Y
  • Organizer: JSSR International Symposium : Pathophysiological hypothesis/model-oriented research of schizophrenia
  • Int'l Joint Research / Invited
• [Presentation] 精神疾患のE/Iバランス異常 -統合失調症を中心に- (2021)
  • Author(s): 平野羊嗣
  • Organizer: 日本臨床精神神経薬理学会
  • Invited
• [Presentation] The progress of the Asian Consortium on MRI studies in Psychosis (ACMP) (2021)
  • Author(s): Koike S, Morita K, Okada N, Xin Yu, Jun Soo Kwon, Kasai K
  • Organizer: 8th BESETO International Psychiatry Conference
  • Int'l Joint Research
• [Presentation] 精神病ハイリスク群と初回エピソード精神病群におけるマルチモダリティ脳計測と臨床転帰の関係 (2021)
  • Author(s): 小池進介
  • Organizer: 第24回日本精神保健・予防学会学術集会
  • Invited
• [Presentation] Socio-medical efficacy and reducing stigma after renaming schizophrenia in Japan (2021)
  • Author(s): Koike S
  • Organizer: 2021年大韓民国統合失調症学会
  • Int'l Joint Research / Invited
• [Presentation] 精神疾患における脳溝・脳回パターンの偏倚 -疾患横断的・疾患特異的な病態神経回路の解明に向けて-. (2021)
  • Author(s): 笹林大樹
  • Organizer: 第43回日本生物学的精神医学会
• [Presentation] 精神病発症危険状態におけるgyrificationの偏倚と認知機能障害との関連 (2021)
  • Author(s): 笹林大樹
  • Organizer: 第15回日本統合失調症学会
• [Remarks] Asian Consortium on MRI in Psychosis
  • URL: http://asia-mri-consortium.net/
• [Patent(Industrial Property Rights)] 脳波・脳磁図計測中に即時に活動源推定と連続Wavelet変換を行う方法 (2021)
  • Inventor(s): 平野羊嗣・田村俊介・中西翔一郎
  • Industrial Property Rights Holder: 平野羊嗣・田村俊介・中西翔一郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: K2020-0146