Toward reconstructing psychiatric disorders based on brain structure and function: International joint research project

2022 Fiscal Year Research-status Report

• Project/Area Number: 20KK0193
• Research Institution: University of Miyazaki
• Principal Investigator: 平野 羊嗣 宮崎大学, 医学部, 准教授 (90567497)
• Co-Investigator(Kenkyū-buntansha): 小池 進介 東京大学, 大学院総合文化研究科, 准教授 (10633167) ; 中島 振一郎 慶應義塾大学, 医学部(信濃町), 講師 (60383866) ; 笹林 大樹 富山大学, 学術研究部医学系, 助教 (80801414)
• Project Period (FY): 2020-10-27 – 2025-03-31
• Keywords: 精神疾患 / バイオタイプ / 脳構造 / 脳機能 / 国際共同研究

Outline of Annual Research Achievements

本国際協同研究は、精神疾患の共通性/異種性バイオタイプ開発を視野に入れた、アジア発の精神疾患の脳構造(ACMP)および脳機能(ACEP)研究の拠点構築を目標とする。本研究により『脳構造と脳機能から精神疾患を再定義』することで、精神疾患全体の本質的な理解と治療法の再構築を目指す。各自の実績は以下の通り。
<平野>ACEPの研究をさらに推進した。具体的には、海外の脳波関連の共同研究施設とは国際学会での会議やWEB会議で連携しつつ、臨床脳波を用いた国内の共同研究に関する統括およびデータ収集、解析パイプラインの構築、さらには参加施設の拡充(7施設から11施設に拡大)を行った。また、本研究に関わる論文18本を国際専門誌に投稿し受理され、国際学会でも本国際協同研究で得られた知見を発表し情報を共有した。
<小池>ACMPの研究をさらに推進した。具体的には、アジア諸国の共同研究参画7施設の脳構造データと臨床データを取りまとめ、前処理を一括して、2022年度にデータ配布を開始した。また、国際学会にてシンポジウム等で積極的に発表し、本研究に関わる論文15本を国際専門誌に投稿し受理された。
<中島>ACEP/ACMPの一環で、治療抵抗性統合失調症（TRS）におけるASSRとGABAの異常を明らかにし、3つの国際専門誌に発表した。さらにTRSに関する最新のReviewをMol.Psychiatryに掲載した。また国際学会にてシンポジウム等で積極的に発表し、トロント大学と密に連携しながら本国際協同研究に関わる論文20本を国際専門誌に投稿し受理された。
<笹林>ACMP内の2つの研究計画に関する臨床・MRIデータの確認・補充を行った。また今後の本解析に向けて、多施設で集められた脳画像の施設間差を減らすハーモナイゼーション技術の習熟に努めた。また、本研究に関わる論文12本を国際専門誌に投稿し受理された。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

COVID-19感染症が徐々に収束する中、各参画施設や病院の指針に従いながら、WEB会議やWEB上でのデータの共有に加え、実験や海外の学会や研究施設への渡航を再開し、データ収集と解析パイプラインの構築、さらには論文化を行うことで、予定していた研究を進めることができた。今年度は、本研究に関わる知見を国際学会のシンポジウム等で積極的に発表し、さらには、論文65本(平野:18本、小池:15本、中島:20本、笹林:12本)が多数の国際専門誌に受理されており、十分成果を出すことが出来たと考える。

Strategy for Future Research Activity

今後は、ACMPとACEPを主軸に、さらなるデータ収集とその解析、また既存データの集積と統合解析も合わせて行っていく。さらに、国内外の脳波・MRI/MRS関連の共同研究施設との連携をより強固にするため、直接海外の研究施設に赴き、最新のデータ取得手法や解析技術を習得しそれを応用し各々のデータを多角的に解析しそれを統合する。特に分担研究者の笹林はハーバード大学に長期間赴き、最新の脳機能と脳構造、ネットワーク回路を統合したマルチモーダルの解析パイプラインの構築を習得する。他のメンバーも各々トロント大学やマギル大学、ハーバード大学などのコラボ先の研究施設に赴き、新たな技術の習得、データ共有、解析手法の習得を進める予定である。

Causes of Carryover

COVID-19感染拡大の影響で一部の実験や海外派遣が延期になったため。

Remarks

本国際共同研究に関する詳細や業績は上記ウェブサイトにUPされている。

Research Products

• [Int'l Joint Research] Harvard Medical School/Children's Hospital of Philadelphia/UCSF(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Harvard Medical School/Children's Hospital of Philadelphia/UCSF
  • # of Other Institutions: 2
• [Int'l Joint Research] University of Toronto/McGill University/University of Ottawa(カナダ)
  • Country Name: CANADA
  • Counterpart Institution: University of Toronto/McGill University/University of Ottawa
• [Int'l Joint Research] University of Melbourne/The Royal Melbourne Hospital/UNSW Sydney(オーストラリア)
  • Country Name: AUSTRALIA
  • Counterpart Institution: University of Melbourne/The Royal Melbourne Hospital/UNSW Sydney
• [Int'l Joint Research] National Taiwan University Hospital/National Cheng Kung University Hospital/Peking University(中国)
  • Country Name: CHINA
  • Counterpart Institution: National Taiwan University Hospital/National Cheng Kung University Hospital/Peking University
  • # of Other Institutions: 1
• [Int'l Joint Research] Seoul National University/Chonbuk National University Hospital/CHA Bundang Medical Center(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: Seoul National University/Chonbuk National University Hospital/CHA Bundang Medical Center
• [Int'l Joint Research]
  • # of Other Countries: 2
• [Journal Article] Cortical representation of speech temporal information through high gamma-band activity and its temporal modulation (2023)
  • Author(s): Tamura Shunsuke、Hirano Yoji
  • Journal Title: Cerebral Cortex Volume: 33 Pages: 8773～8782
  • DOI: 10.1093/cercor/bhad158
  • Peer Reviewed / Open Access
• [Journal Article] Combination psychotropic use for schizophrenia with long-acting injectable antipsychotics and oral antipsychotics: A nationwide real-world study in Japan (2023)
  • Author(s): Onitsuka T, Okada T,…Hirano Y, Watanabe K, Inada K, Hashimoto R
  • Journal Title: Journal of Clinical Psychopharmacology Volume: (in press) Pages: -
  • DOI: 10.1097/JCP.0000000000001704
  • Peer Reviewed / Open Access
• [Journal Article] A case study of the utilization of clozapine treatment for treatment-resistant schizophrenia associated with 22q11.2 deletion syndrome (2023)
  • Author(s): Tsurue A, Funahashi H, Tsurue K, Kawano M, Ishida Y, Hirano Y*
  • Journal Title: Neuropsychopharmacology Reports Volume: (in press) Pages: -
  • DOI: 10.1002/npr2.12333
  • Peer Reviewed / Open Access
• [Journal Article] Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy (2023)
  • Author(s): Eiro T, Miyazaki T, Hatano M,… Hirano Y, Kimura Y, Matsumoto R, Ikeda A, Takahashi T
  • Journal Title: Cell Reports Medicine Volume: 4 Pages: 101020
  • DOI: 10.1016/j.xcrm.2023.10102
  • Peer Reviewed / Open Access
• [Journal Article] The Contribution of Gamma Bursting to Spontaneous Gamma Activity in Schizophrenia (2023)
  • Author(s): Spencer KM, Nakhnikian A, Hirano Y, Levin M
  • Journal Title: Frontiers in Human Neuroscience Volume: 17 Pages: 1130897
  • DOI: 10.3389/fnhum.2023.11308
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinctive alterations in the mesocorticolimbic circuits in various psychiatric disorders (2023)
  • Author(s): Nakamura Y, Ishida T, Tanaka SC,...Koike S
  • Journal Title: Psychiatry Clin Neurosci Volume: in press Pages: -
  • DOI: 10.1111/pcn.13542
  • Peer Reviewed
• [Journal Article] Aberrant large-scale network interactions across psychiatric disorders revealed by large-sample multi-site resting-state functional magnetic resonance imaging datasets (2023)
  • Author(s): Ishida T, Nakamura Y, Tanaka SC, Mitsuyama Y, Yokoyama S, Shinzato H, Itai E, Okada G, Kobayashi Y, Kawashima T, Miyata J, Yoshihara Y, Takahashi H, Morita S, Kawakami S, Abe O, Okada N, Kunimatsu A, Yamashita A, Yamashita O, Imamizu H, Morimoto J, Okamoto Y, Murai T, Kasai K, Kawato M, Koike S
  • Journal Title: Schizophr Bull Volume: in press Pages: -
  • DOI: 10.1093/schbul/sbad022
  • Peer Reviewed / Open Access
• [Journal Article] Music rhythm perception and production relate to treatment response in schizophrenia (2023)
  • Author(s): Honda S, Matsushita K, Noda Y, Tarumi R, Nomiyama N, Tsugawa S, Nakajima S, Mimura M, Fujii S
  • Journal Title: Schizophrenia Research Volume: 252 Pages: 69～76
  • DOI: 10.1016/j.schres.2022.12.040
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal changes in clozapine dose in patients with treatment-resistant schizophrenia: a 5-year retrospective cohort study (2023)
  • Author(s): Tsukahara M, So R, Nakajima S, Kitagawa K, Kodama M, Takeuchi H
  • Journal Title: International Clinical Psychopharmacology Volume: 38 Pages: 96-101
  • DOI: 10.1097/YIC.0000000000000429
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutamatergic Neurometabolite Levels in Bipolar Disorder: A Systematic Review and Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies (2023)
  • Author(s): Ino H, Honda S, Yamada K, Horita N, Tsugawa S, Yoshida K, Noda Y, Meyer JH, Mimura M, Nakajima S, Moriguchi S.
  • Journal Title: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Volume: 8 Pages: 140～150
  • DOI: 10.1016/j.bpsc.2022.09.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia (2023)
  • Author(s): Kim J, Song J, Kambari Y, Plitman E, Shah P, Iwata Y, Caravaggio F, Brown EE, Nakajima S, Chakravarty MM, De Luca V, Remington G, Graff-Guerrero A, Gerretsen P.
  • Journal Title: Schizophrenia Volume: 9 Pages: -
  • DOI: 10.1038/s41537-023-00347-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, Koike S, Sasabayashi D, Katayama H, Plitman E, Ohi K, Ueno F, Caravaggio F, Koizumi T, Gerretsen P, Suzuki T, Uchida H, Mimura M, Remington G, Grace AA, Graff-Guerrero A, Nakajima S
  • Journal Title: Molecular Psychiatry Volume: 27 Pages: 2950-2967
  • DOI: 10.1038/s41380-022-01572-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transdiagnostic Comparisons of Intellectual Abilities and Work Outcome in Patients with Mental Disorders: A Multicentre Study (2022)
  • Author(s): Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Matsumoto J, Miura K, Hashimoto N, Makinoda M, Takahashi T, Nemoto K, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R
  • Journal Title: BJPsych Open Volume: 8 Pages: e98
  • DOI: 10.1192/bjo.2022.50.
  • Peer Reviewed / Open Access
• [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools (2022)
  • Author(s): Koike S, Uematsu A, Sasabayashi D, Maikusa N, Takahashi T, Ohi K, Nakajima S, Noda Y, Hirano Y
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 21 Pages: 539-552
  • DOI: 10.2463/mrms.rev.2021-0050
  • Peer Reviewed / Open Access
• [Journal Article] Toward Recovery in Schizophrenia: Current Concepts, Findings, and Future Research Directions (2022)
  • Author(s): Onitsuka T, Hirano Y, Nakazawa T, Ichihashi K, Miura K, Inada K, Mitoma R, Yasui-Furukori N, Hashimoto R.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Pages: 282-291
  • DOI: 10.1111/pcn.13342
  • Peer Reviewed / Open Access
• [Journal Article] Volume reduction of the dorsal lateral prefrontal cortex prior to the onset of frank psychosis in individuals with an at-risk mental state. (2022)
  • Author(s): Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Ohmuro N, Katsura M, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
  • Journal Title: Cerebral Cortex Volume: 32 Pages: 2245-2253
  • DOI: 10.1093/cercor/bhab353
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Application of a machine learning algorithm for structural brain images in chronic schizophrenia to earlier clinical stages of psychosis and autism spectrum disorder: A multi-protocol imaging dataset study (2022)
  • Author(s): Zhu Y, Nakatani H, Yassin W, Maikusa N, Okada N, Kunimatsu A, Abe O, Kuwabara H, Yamasue H, Kasai K, Okanoya K, Koike S
  • Journal Title: Schizophrenia Bulletin Volume: 48 Pages: 563-574
  • DOI: 10.1093/schbul/sbac030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Shared functional impairment in the prefrontal cortex affects symptom severity across psychiatric disorders (2022)
  • Author(s): Koike S, Sakakibara E, Satomura Y, Sakurada H, Yamagishi M, Matsuoka J, Okada N, Kasai K
  • Journal Title: Psychological Medicine Volume: 52 Pages: 2661-2670
  • DOI: 10.1017/S0033291720004742
  • Peer Reviewed
• [Journal Article] AMPA receptors in schizophrenia: A systematic review of postmortem studies on receptor subunit expression and binding (2022)
  • Author(s): Yonezawa K, Tani H, Nakajima S, Nagai N, Koizumi T, Miyazaki T, Mimura M, Takahashi T, Uchida H
  • Journal Title: Schizophrenia Research Volume: 243 Pages: 98-109
  • DOI: 10.1016/j.schres.2022.02.033
  • Peer Reviewed
• [Journal Article] Decision tree classification of cognitive functions with D(2) receptor occupancy and illness severity in late-life schizophrenia (2022)
  • Author(s): Kusudo K, Ochi R, Nakajima S, Suzuki T, Mamo D, Caravaggio F, Mar W, Gerretsen P, Mimura M, Pollock BG, Mulsant BH, Graff-Guerrero A, Rajji TK, Uchida H.
  • Journal Title: Schizophrenia Research Volume: 241 Pages: 113-115
  • DOI: 10.1016/j.schres.2022.01.044
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients (2022)
  • Author(s): Ismail M, Straubinger T, Uchida H, Graff-Guerrero A, Nakajima S, Suzuki T, Caravaggio F, Gerretsen P, Mamo D, Mulsant BH, Pollock BG, Bies R.
  • Journal Title: British Journal of Clinical Pharmacology Volume: 88 Pages: 3341-3350
  • DOI: 10.1111/bcp.15260
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The effects of acute dopamine depletion on resting-state functional connectivity in healthy humans (2022)
  • Author(s): Caravaggio F, Barnett AJ, Nakajima S, Iwata Y, Kim J, Borlido C, Mar W, Gerretsen P, Remington G, Graff-Guerrero A.
  • Journal Title: European Neuropsychopharmacology Volume: 57 Pages: 39-49
  • DOI: 10.1016/j.euroneuro.2022.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroimaging-derived brain age is associated with life satisfaction in cognitively unimpaired elderly: A community-based study (2022)
  • Author(s): Sone D, Beheshti I, Shinagawa S, Niimura H, Kobayashi N, Kida H, Shikimoto R, Noda Y, Nakajima S, Bun S, Mimura M, Shigeta M.
  • Journal Title: Translational Psychiatry Volume: 12 Pages: 25
  • DOI: 10.1038/s41398-022-01793-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Investigating structural subdivisions of the anterior cingulate cortex in schizophrenia, with implications for treatment resistance and glutamatergic levels (2022)
  • Author(s): Ochi R, Plitman E, Patel R, Tarumi R, Iwata Y, Tsugawa S, Kim J, Honda S, Noda Y, Uchida H, Devenyi GA, Mimura M, Graff-Guerrero A, Chakravarty MM, Nakajima S.
  • Journal Title: Journal of Psychiatry and Neuroscience Volume: 47 Pages: E1-E10
  • DOI: 10.1503/jpn.210113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis (2022)
  • Author(s): Ueno F, Iwata Y, Nakajima S, Caravaggio F, Rubio JM, Horga G, Cassidy CM, Torres-Carmona E, de Luca V, Tsugawa S, Honda S, Moriguchi S, Noda Y, Gerretsen P, Graff-Guerrero A.
  • Journal Title: Neuroscience & Biobehavioral Reviews Volume: 132 Pages: 1205-1213
  • DOI: 10.1016/j.neubiorev.2021.10.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of (1)H-magnetic resonance spectroscopy studies (2022)
  • Author(s): Nakahara T, Tsugawa S, Noda Y, Ueno F, Honda S, Kinjo M, Segawa H, Hondo N, Mori Y, Watanabe H, Nakahara K, Yoshida K, Wada M, Tarumi R, Iwata Y, Plitman E, Moriguchi S, de la Fuente-Sandoval C, Uchida H, Mimura M, Graff-Guerrero A, Nakajima S.
  • Journal Title: Molecular Psychiatry Volume: 27 Pages: 44-757
  • DOI: 10.1038/s41380-021-01297-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Frontostriatal Structural Connectivity andStriatal Glutamatergic Levels in Treatment-Resistant Schizophrenia: AnIntegrative Analysis of DTI and 1H-MRS. (2022)
  • Author(s): Ochi R, Tarumi R, Noda Y, Tsugawa S, Plitman E, Wada M, HondaS, Matsushita K, Chakravarty MM, Graff-Guerrero A, Fujii S, Matsui M, Uchida H, Mimura M, Nakajima S.
  • Journal Title: Schizophrenia Bulletin Open Volume: 1 Pages: sgaa057
  • DOI: 10.1093/schizbullopen/sgaa057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multi-modal imaging of the auditory-larynx motor network for voicing perception (2022)
  • Author(s): Tamura S, Hirose H, Mitsudo T, Hoaki N, Nakamura I, Onitsuka T, Hirano Y
  • Journal Title: NeuroImage Volume: 251 Pages: 118981-118981
  • DOI: 10.1016/j.neuroimage.2022
  • Peer Reviewed / Open Access
• [Journal Article] Trends in Big Data Analyses by Multicenter Collaborative Translational Research in Psychiatry (2022)
  • Author(s): Onitsuka T, Hirano Y, Nemoto K, Hashimoto N, Kushima I, Koshiyama D, Koeda M, Takahashi T, Noda Y, Matsumoto J, Miura K, Nakazawa T, Hikida T, Kasai K, Ozaki N, Hashimoto R
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Pages: 14-Jan
  • DOI: 10.1111/pcn.13311
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial (2022)
  • Author(s): Yamasue H, Kojima M,…Hirano Y, Onitsuka T, Kosaka H, Okada T.
  • Journal Title: Brain Volume: 145 Pages: 490-499
  • DOI: 10.1093/brain/awab291
  • Peer Reviewed / Open Access
• [Journal Article] Multi-modal imaging of the auditory-larynx motor network for voicing perception (2022)
  • Author(s): Tamura S, Hirose N, Mitsudo T, Hoaki N, Nakamura I, Onitsuka T, Hirano Y.
  • Journal Title: NeuroImage Volume: 251 Pages: 118981
  • DOI: 10.1016/j.neuroimage.2022.
  • Peer Reviewed / Open Access
• [Journal Article] Effects of electroconvulsive therapy on the use of anxiolytics and sleep medications: a propensity score matched analysis (2022)
  • Author(s): Tsuboi T, Takaesu Y,…Hirano Y, Makinodan M, Matsumoto J, Miura K, Hishimoto A, Numata S, Yamada H, Yasui-Furukori N, Inada K, Watanabe K, Hashimoto R.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 77 Pages: 30-37
  • DOI: 10.1111/pcn.13489
  • Peer Reviewed / Open Access
• [Journal Article] Phase Delay of the 40_Hz Auditory Steady-State Response Localizes to Left Auditory Cortex in Schizophrenia (2022)
  • Author(s): Roach BJ, Hirano Y, Ford JM, Spencer KM, Mathalon DH
  • Journal Title: Clinical EEG and Neuroscience Volume: (in press) Pages: -
  • DOI: 10.1177/155005942211308
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuronal imbalance of excitation and inhibition in schizophrenia: a scoping review of gamma-band ASSR findings (2022)
  • Author(s): Onitsuka T, Tsuchimoto R, Oribe N, Spencer KM, Hirano Y*
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Pages: 610-619
  • DOI: 10.1111/pcn.13472
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Association between Electroencephalography with Auditory Steady-State Response and Postoperative Delirium (2022)
  • Author(s): Arai N, Miyazaki T, Nakajima S, Okamoto S, Moriyama S, Niinomi K, Takayama K, Kato J, Nakamura I, Hirano Y, Kitago M, Kitagawa Y, Takahashi T, Shimizu H, Mimura M, Noda Y
  • Journal Title: Journal of Personalized Medicine Volume: 13 Pages: 35
  • DOI: 10.3390/jpm13010035
  • Peer Reviewed / Open Access
• [Journal Article] Decreased cortical gyrification and surface area in the left medial parietal cortex in patients with treatment-resistant and ultratreatment-resistant schizophrenia (2022)
  • Author(s): Kitajima K, Tamura S, Sasabayashi D, Nakajima S, Iwata Y, Ueno F, Takai Y, Takahashi J, Caravaggio F, Mar W, Torres-Carmona E, Noda Y, Gerretsen P, Luca V, Mimura M, Hirano S, Nakao T, Onitsuka T, Remington G, Graff-Guerrero A, Hirano Y*.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 77 Pages: 11-Feb
  • DOI: 10.1111/pcn.13482
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decrease in gamma-band auditory steady-state response in patients with treatment-resistant schizophrenia (2022)
  • Author(s): Ogyu K, Matsushita K, Honda S, Wada M, Tamura S, Takenouchi K, Tobari Y, Kusudo K, Kato H, Koizumi T, Arai N, Koreki A, Matsui M, Uchida H, Fujii S, Onaya M, Hirano Y, Mimura M, Nakajima S, Noda Y
  • Journal Title: Schizophrenia Research Volume: 252 Pages: 129-137
  • DOI: 10.1016/j.schres.2023.01.0
  • Peer Reviewed / Open Access
• [Journal Article] The association between clinical symptoms and later subjective quality of life in individuals with ultra-high risk for psychosis and recent-onset psychotic disorder: A longitudinal investigation (2022)
  • Author(s): Usui K, Kirihara K, Tada M, Fujioka M, Koshiyama D, Tani M, Tsuchiya M, Morita S, Kawakami S, Kanehara A, Morita K, Satomura Y, Koike S, Suga M, Araki T, Kasai K
  • Journal Title: Psychiatry Clin Neurosci Volume: 76 Pages: 552-9
  • DOI: 10.1111/pcn.13359
  • Peer Reviewed
• [Journal Article] Retrospective Chart Review-based Assessment Scale for Adverse Childhood Events and Experiences (2022)
  • Author(s): Yamagishi M, Satomura Y, Sakurada H, Kanehara A, Sakakibara E, Okada N, Koike S, Yagishita S, Ichihashi K, Kondo S, Jinde S, Fukuda M, Kasai K
  • Journal Title: Psychiatry Clin Neurosci Reports Volume: in press Pages: -
  • DOI: 10.1002/pcn5.58
  • Peer Reviewed
• [Journal Article] Editorial: Prognostic imaging biomarkers in psychotic disorders (2022)
  • Author(s): Sasabayashi D, Koike S, Nakajima S, Hirano Y
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 1053836
  • DOI: 10.3389/fpsyt.2022.1053836
  • Peer Reviewed / Open Access
• [Journal Article] Increased brain gyrification and subsequent relapse in patients with first-episode schizophrenia (2022)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Furuichi A, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 937605
  • DOI: 10.3389/fpsyt.2022.937605
  • Peer Reviewed / Open Access
• [Journal Article] Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis (2022)
  • Author(s): Baldwin H, Radua J,… Koike S,... Sasabayashi D,.. Fusar-Poli P; ENIGMA Clinical High Risk for Psychosis Working Group.
  • Journal Title: Translational Psychiatry Volume: 12 Pages: 297
  • DOI: 10.1038/s41398-022-02057-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Different Heschl’s Gyrus Duplication Patterns in Deficit and Non-deficit Subtypes of Schizophrenia (2022)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 867461
  • DOI: 10.3389/fpsyt.2022.867461
  • Peer Reviewed / Open Access
• [Journal Article] Development and validation of a scale of self-alienation-related attributes for the early diagnosis of schizophrenia (2022)
  • Author(s): Nishiyama S, Kurachi M, Higuchi Y, Takahashi T, Sasabayashi D, Mizukami Y, Suzuki M
  • Journal Title: Journal of Psychiatric Research Volume: 147 Pages: 212-220
  • DOI: 10.1016/j.jpsychires.2022.01.020
  • Peer Reviewed
• [Journal Article] An exploratory, open-label, randomized, multicenter trial of hachimijiogan for mild Alzheimer’s disease (2022)
  • Author(s): Kainuma M, Ouma S, Kawakatsu S, Iritani O, Yamashita KI, Ohara T, Hirano S, Suda S, Hamano T, Hieda S, Yasui M, Yoshiiwa A, Shiota S, Hironishi M, Wada-Isoe K, Sasabayashi D, Yamasaki S, Murata M, Funakoshi K, Hayashi K, Shirafuji N, Sasaki H, Kajimoto Y, Mori Y, Suzuki M, Ito H, Ono K, Tsuboi Y.
  • Journal Title: Frontiers in Pharmacology Volume: 13 Pages: 991982
  • DOI: 10.3389/fphar.2022.991982
  • Peer Reviewed / Open Access
• [Journal Article] Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study (2022)
  • Author(s): Takahashi T, Tsugawa S, Nakajima S, Plitman E, Chakravarty MM, Masuda F, Wada M, Kurose S, Ochi R, Matsushita K, Sasabayashi D, Nakamura M, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Hashimoto R, Noguchi K, Fujii S, Mimura M, Noda Y, Suzuki M
  • Journal Title: Schizophrenia Research Volume: 243 Pages: 268-275
  • DOI: 10.1016/j.schres.2020.04.016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders (2022)
  • Author(s): Takahashi T, Sasabayashi D, Yucel M, Whittle S, Lorenzetti V, Walterfang M, Suzuki M, Pantelis C, Malhi GS, Allen NB
  • Journal Title: Frontiers in Human Neuroscience Volume: 16 Pages: 917270
  • DOI: 10.3389/fnhum.2022.917270
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gross anatomical features of the insular cortex in schizophrenia and schizotypal personality disorder: Potential relationships with vulnerability, illness stages, and clinical subtypes (2022)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kobayashi H, Yuasa Y, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 1050712
  • DOI: 10.3389/fpsyt.2022.1050712
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacotherapeutic combinations for the treatment of Alzheimer’s disease (2022)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kobayashi H, Yuasa Y, Noguchi K, Suzuki M
  • Journal Title: Expert Opinion on Pharmacotherapy Volume: 23 Pages: 727～737
  • DOI: 10.1080/14656566.2022.2042514
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia (2022)
  • Author(s): Kubota M, Takahata K, Matsuoka K, Sano Y, Yamamoto Y, Tagai K, Tarumi R, Suzuki H, Kurose S, Nakajima S, Shiwaku H, Seki C, Kawamura K, Zhang MR, Takahashi H, Takado Y, Higuchi M
  • Journal Title: Schizophrenia Bulletin Volume: 49 Pages: 688～696
  • DOI: 10.1093/schbul/sbac181
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Findings of (18) F-PI-2620 tau PET imaging in patients with Alzheimer's disease and healthy controls in relation to the plasma P-tau181 levels in a Japanese sample (2022)
  • Author(s): Bun S, Moriguchi S, Tezuka T, Sato Y, Takahata K, Seki M, Nakajima S, Yamamoto Y, Sano Y, Suzuki N, Morimoto A, Ueda R, Tabuchi H, Ito D, Mimura M.
  • Journal Title: Neuropsychopharmacology Reports Volume: 42 Pages: 437～448
  • DOI: 10.1002/npr2.12281
  • Peer Reviewed / Open Access
• [Presentation] Two gaps in clinical MRI study findings (2023)
  • Author(s): Koike S
  • Organizer: IRCN Computational psychiatry workshop
  • Invited
• [Presentation] Bi-directional translational approach from the findings in human neuroimaging studies (2023)
  • Author(s): 小池進介
  • Organizer: 第100回日本生理学会大会
• [Presentation] Brain Network Alterations as Potential Therapeutic Targets in Psychosis (2022)
  • Author(s): Hirano Y
  • Organizer: 22rd WPA World Congress of Psychiatry
  • Int'l Joint Research / Invited
• [Presentation] 疾患横断的な脳波の多施設共同研究 (2022)
  • Author(s): 平野羊嗣
  • Organizer: 第118回日本精神神経学会学術総会・AMED協賛シンポジウム
  • Invited
• [Presentation] 統合失調症のニューラルオシレーション異常 (2022)
  • Author(s): 平野羊嗣
  • Organizer: 第118回日本精神神経学会学術総会・PCN協賛シンポジウム
  • Invited
• [Presentation] 精神疾患の神経生理学的知見 －統合失調症を中心に－ (2022)
  • Author(s): 平野羊嗣
  • Organizer: 第44回日本生物学的精神医学会年会（BPCNPNPPP4学会合同年会）
  • Invited
• [Presentation] The Asian Consortium on MRI Studies in Psychosis (ACMP) (2022)
  • Author(s): Koike S, Okada N
  • Organizer: 9th BESETO International Psychiatry Conference
  • Int'l Joint Research
• [Presentation] 1,000計測以上の縦断脳画像データの解析技法開発と臨床応用 (2022)
  • Author(s): 小池進介
  • Organizer: 第44回日本生物学的精神医学会年会（BPCNPNPPP4学会合同年会）
• [Presentation] MRI構造画像による精神疾患の機械学習と、その精緻化に向けた取り組み (2022)
  • Author(s): 小池進介
  • Organizer: 第44回日本生物学的精神医学会年会（BPCNPNPPP4学会合同年会）
• [Presentation] 脳画像機械学習による統合失調症の発症予測と実装化に向けた取り組み (2022)
  • Author(s): 小池進介
  • Organizer: 第41回日本精神科診断学会
• [Presentation] 思春期における精神疾患へのスティグマ形成過程と家庭内伝播の検討 (2022)
  • Author(s): 小池進介
  • Organizer: 第113回日本精神神経学会学術集会
• [Presentation] 脳MRI多施設共同研究に必要なハーモナイゼーション技術 (2022)
  • Author(s): 小池進介
  • Organizer: 第113回日本精神神経学会学術集会
• [Presentation] 双方向トランスレーショナルアプローチによる統合失調症病態解明に向けて (2022)
  • Author(s): 小池進介
  • Organizer: 第113回日本精神神経学会学術集会
• [Presentation] The alteration of effective connectivity across psychiatric disorders (2022)
  • Author(s): Koike S
  • Organizer: the Korean Society for Brain and Neural Sciences
  • Int'l Joint Research / Invited
• [Presentation] At-risk mental stateおよび統合失調症 におけるdefault mode network に関連した安静時機能的結合の変化 (2022)
  • Author(s): 笹林大樹, 高橋努, 高柳陽一郎, 根本清貴, 上野摩耶, 古市厚志, 樋口悠子, 水上祐子, 西山志満子, 小林春子, Tien Viet Pham, 野口 京, 鈴木道雄
  • Organizer: 第16回統合失調症学会
• [Presentation] 統合失調症を脳のかたちや大きさの特徴から早期に診断することはできるか? (2022)
  • Author(s): 笹林大樹
  • Organizer: 第16回統合失調症学会
  • Invited
• [Presentation] ARMS群における大脳皮質厚の変化と 1年後の機能的転帰との関連 (2022)
  • Author(s): 笹林大樹
  • Organizer: 第16回統合失調症学会
  • Invited
• [Presentation] At-risk mental stateへの臨床的支援 ~Consultation and Support Service in Toyama (CAST)~ハ (2022)
  • Author(s): 笹林大樹
  • Organizer: 第200回北陸精神神経学会
• [Presentation] 統合失調症および妄想性障害におけるdefault mode networkに関連した安静時機能的結合性の増加 (2022)
  • Author(s): 笹林大樹, 高橋努, 石戸憩, 白井秀昂, 高柳陽一郎, 根本清貴, 上野摩耶, 古市厚志, 小林春子, 野口京, 鈴木道雄
  • Organizer: 第44回日本生物学的精神医学会年会（BPCNPNPPP4学会合同年会）
• [Presentation] 精神病性障害における 脳回形成の偏倚に関する研究 (2022)
  • Author(s): 笹林大樹
  • Organizer: 第44回日本生物学的精神医学会年会（BPCNPNPPP4学会合同年会）
• [Presentation] 初回エピソード統合失調症患者における脳表形態特徴とその後の再燃との関連 (2022)
  • Author(s): 笹林大樹、高柳陽一郎、高橋努、古市厚志、小林春子、湯浅悠介、野口京、鈴木道雄
  • Organizer: 第25回日本精神保健・予防学会学術集会
• [Presentation] 精神神経医療における「聖杯」とは：Disease-Modifying Therapyの現在地と可能性 (2022)
  • Author(s): 中島振一郎
  • Organizer: 第118回日本精神神経学会学術総会
• [Presentation] 脳画像研究最前線 (2022)
  • Author(s): 中島振一郎
  • Organizer: 第17回日本統合失調症学会
• [Book] 精神医学領域の論文を読みこなすキーワード100！ (2022)
  • Author(s): 平野羊嗣（編著分担：神経生理）
  • Total Pages: 280
  • Publisher: 新興医学出版社
  • ISBN: 9784880028866
• [Book] 統合失調症薬物治療ガイド2022―患者と支援者のために― (2022)
  • Author(s): 青木裕見、市橋香代、井手健太、稲垣中、稲田健、稲見聡、大井一高、柏木宏子、勝元榮一、加藤玲、菊地紗耶、佐々木剛、佐々木典子、鈴木みずめ、須田史朗、武市尚子、樽谷精一郎、飛田憲彦、冨田哲、中越由美子、沼田周助、根本清貴、橋本直樹、橋本亮太、林岳宏、平野羊嗣 他
  • Total Pages: 42
  • Publisher: 日本神経精神薬理学会・日本臨床精神神経薬理学会
• [Remarks] Asian Consortium on EEG studies in Psychosis
  • URL: http://acep.saturn.bindcloud.jp/
• [Remarks] Asian Consortium on MRI in Psychosis
  • URL: https://asia-mri-consortium.net/
• [Patent(Industrial Property Rights)] 脳波・脳磁図計測中に即時に活動源推定と連続Wavelet変換を行う方法 (2022)
  • Inventor(s): 平野羊嗣・田村俊介・中西翔一郎
  • Industrial Property Rights Holder: 平野羊嗣・田村俊介・中西翔一郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: K2020-0146
• [Patent(Industrial Property Rights)] 脳機能関連疾病評価装置及び脳機能関連疾病評価方法 (2022)
  • Inventor(s): 平野羊嗣・田村俊介
  • Industrial Property Rights Holder: 平野羊嗣・田村俊介
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: K2022-74916