2011 Fiscal Year Final Research Report
Development of DNA-Chip-Based Electronic Devices for Nanobio Sensing Applications
| Project/Area Number |
21200034
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Analytical chemistry
Nanomaterials/Nanobioscience
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKANO Kouji 九州大学, 工学研究院応用化学部門, 准教授 (10180324)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナノバイオ / ＤＮＡ / 自己組織化 / 分子認識 / バイオセンサー / 遺伝子センサー / 分子エレクトロニクス / 走査プローブ顕微鏡 |
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| Research Abstract |
DNA-based molecular device that is capable of responding to biological molecular recognition events was tackled for futuristic nano-, bio-device developments based on in-situ electoconductive modification of DNA self-assembly. Some direct or indirect assistance necessary to the goal were successfully developed; novel psoralen compounds that enable versatile functionalization of DNA duplexes by covalent conjugation, single-molecule assay for various DNA affinity reactions including single-nucleotide polymorphism using atomic force microscope, new types of bottom-up, supramolecular DNA nanomaterials based on dendrimer formation of three-way junction DNA, and etc. We are committed to taking on the challenges by installing the DNA dendrimer materials into interdigitated array electrode to provide state-of-the-art, molecularly responsive devices adaptable to various bioanalytical purposes.
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[Journal Article] Structure-Reactivity Relationship of Piperidine Nitroxide: Electrochemical, ESR and Computational Studies2011
Author(s)
T. Yamasaki, F. Mito, Y. Ito, S. Pansian, Y. Konoshita, K. Nakano, R. Murugesan, K. Sakai, H. Utsumi, K.Yamada
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Journal Title
J. Organic Chemistry
Volume: Vol. 76, No. 2
Pages: 435-440
Peer Reviewed
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