2011 Fiscal Year Final Research Report
Establishment of a new paradigm in the phosphoinositide research
| Project/Area Number |
21200075
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
Biological pharmacy
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| Research Institution | Akita University |
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Principal Investigator |
SASAKI Junko 秋田大学, 大学院・医学系研究科, 講師 (30333371)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Takao 国立医薬品食品研究所, 主任研究官 (50361605)
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| Co-Investigator(Renkei-kenkyūsha) |
TAGUCHI Ryo 中部大学, 生命健康科学部, 教授 (20080210)
KOFUJI Satoshi 秋田大学, 大学院・医学系研究科, 助教 (00508153)
TAKASUGA Shunsuke 秋田大学, 大学院・医学系研究科, 助教 (90375262)
EGUCHI Satoshi 秋田大学, 大学院・医学系研究科, 助教 (70457117)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子病態学 |
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| Research Abstract |
There are two isozymes (L-PIPase and P-PIPase) which dephosphorylate PI(3,4)P2. However the functions of L-PIPase and P-PIPase are unclear. In this study we showed that L-PIPase suppresses neuronal cell death after brain ischemia while P-PIPase contributes to malignant progression. We also found that each enzyme has different activities against several PI(3,4)P2 species. It is suggested that the different functions between L-PIPase and P-PIPase might be caused by the substrate specificity.
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[Journal Article] Mammalian phosphoinositide kinases and phosphatases2009
Author(s)
Sasaki, T., Takasuga, S., Sasaki, J., Kofuji, S., Eguchi, S., Yamazaki, M. & Suzuki, A.
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Journal Title
Prog. Lipid Res.
Volume: 48
Pages: 307-343
DOI
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