2012 Fiscal Year Final Research Report
Chemistry of Novel Naturally Occurring Super-carbon-chain Molecules
| Project/Area Number |
21221009
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Kanagawa University (2011-2012)
Keio University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Osamu 慶應義塾大学, 理工学部, 助教 (20436992)
SUENAGA Kiyotake 慶應義塾大学, 理工学部, 准教授 (60273215)
ARIMOTO Hirokazu 東北大学, 生命科学研究科, 教授 (60262789)
MIYAMOTO Kenji 慶應義塾大学, 理工学部, 准教授 (60360111)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 天然物有機化学 / 巨大炭素鎖有機分子 / 生物活性 / 海洋生物共生鞭毛藻 / 生物学的存在意義 / 生体内動態 / メタゲノム |
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| Research Abstract |
We refer to marine organism-derived long carbon chain molecules without repeating motifs as super-carbon-chain molecules. They have extraordinary chemical structures and exhibit strong biological activities. In this study, we endeavored to identify novel super-carbon-chain molecules by a new approach: the large-scale cultivation of symbiotic bacteria or a meta-genomic method. We also studied the biological significance, biological activities, biosynthesis, and unique chemical reactivities of these molecules. As a result, we successfully identified several important molecules and determined their biological activities. Our findings should help to establish the concept of super-carbon-chain molecules.
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[Journal Article] Halichonines A, B, and C, Novel Sesquiterpene Alkaloids from the Marine Sponge Halichondria okadai Kadota2011
Author(s)
O. Ohno, T. Chiba, S. Todoroki, H. Yoshimura, N. Maru, K. Maekawa, H. Imagawa, K. Yamada, A. Wakamiya, K. Suenaga, D. Uemura
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Journal Title
Chem. Commun
Volume: 47
Pages: 12453-12455
DOI
Peer Reviewed
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