2013 Fiscal Year Final Research Report
Imaging analyses of signaling mechanism in central nervous system cell-cell network
| Project/Area Number |
21229004
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
IINO Masamitsu 東京大学, 医学(系)研究科(研究院), 教授 (50133939)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMAZAWA Toshiko 東京大学, 大学院・医学系研究科, 助教 (00282616)
OKUBO Yohei 東京大学, 大学院・医学系研究科, 助教 (40422282)
KANEMARU Kazunori 東京大学, 大学院・医学系研究科, 助教 (10456105)
SEKIYA Hiroshi 東京大学, 大学院・医学系研究科, 助教 (40511374)
|
|---|
| Project Period (FY) |
2009-05-11 – 2014-03-31
|
| Keywords | 受容体 / チャネル / 輸送系 / シグナル情報伝達 |
|---|
| Research Abstract |
We searched for previously unidentified functions of intracellular Ca2+ signals in the central nervous system (CNS) using imaging methods for signaling molecules, and obtained the following results as regard the network mechanism in the CNS. (1) We discovered astrocytic Ca2+ signaling-mediated mechanism for astrogliosis and neuroprotection. (2) We succeeded in the visualization of spatiotemporal dynamics of glutamate signaling. This study was extended to in vivo glutamate imaging, and proved that sensory input induces glutamate spillover. (3) We discovered NO-induced Ca2+ release mechanism (NICR). NICR is involved in the long-term potentiation in the cerebellar cortex and in NO-mediated neuronal cell death.
|
-
[Journal Article] Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury2013
Author(s)
Kanemaru, K., Kubota, J., Sekiya, H., Hirose, K., Okubo, Y. and Iino, M
-
Journal Title
Proc Natl Acad Sci USA
Volume: 110
Pages: 11612-11617
DOI
Peer Reviewed
-
[Journal Article] β-catenin regulates PTH/PTHrP receptor signals and chondrocyte hypertrophy through binding to its intracellular C-terminal region2013
Author(s)
Yano, F., Saito, T., Ogata, N., Yamazawa, T., Iino, M., Chung, U.I. and Kawaguchi, H
-
Journal Title
Arthritis Rheum
Volume: 65
Pages: 429-435
DOI
Peer Reviewed
-
-
-
[Journal Article] Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function2012
Author(s)
Kakizawa, S., Yamazawa, T., Chen, Y., Ito, A., Murayama, T., Oyamada, H., Kurebayashi, N., Sato, O., Watanabe, M., Mori, N., Oguchi, K., Sakurai, T., Takeshima, H., Saito, N. and Iino, M
-
Journal Title
EMBO J
Volume: 31
Pages: 417-428
DOI
Peer Reviewed
-
-
-
[Journal Article] Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia2010
Author(s)
Mashimo, M., Okubo, Y., Yamazawa, T., Yamasaki, M., Watanabe, M., Murayama, T. and Iino, M
-
Journal Title
Eur. J. Neurosci
Volume: 32
Pages: 1668-1677
DOI
Peer Reviewed
-
[Journal Article] Imaging extrasynaptic glutamate dynamics in the brain2010
Author(s)
Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Iinuma, S., Yamasaki, M., Watanabe, M., Hirose, K. and Iino, M
-
Journal Title
Proc. Natl.Acad. Sci. U.S.A.
Volume: 107
Pages: 6526-6531
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
