2013 Fiscal Year Final Research Report
Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure
| Project/Area Number |
21229013
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKAO Kazuwa 京都大学, 医学(系)研究科(研究院), 教授 (00172263)
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| Co-Investigator(Kenkyū-buntansha) |
EBIHARA Ken 京都大学, 医学研究科, 准教授 (70362514)
YASODA Akihiro 京都大学, 医学研究科, 講師 (50378642)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSODA Kiminori 京都大学, 医学研究科, 教授 (40271598)
MUKOYAMA Masashi 京都大学, 医学研究科, 准教授 (40270558)
TAMURA Naohisa 京都大学, 医学研究科, 講師 (40314207)
MORI Kiyoshi 京都大学, 医学研究科, 准教授 (60343232)
KUWAHARA Koichiro 京都大学, 医学研究科, 講師 (30402887)
SONE Masakatsu 京都大学, 医学研究科, 講師 (40437207)
MIYAZAWA Takashi 京都大学, 医学研究科, 特定准教授 (30443500)
SAWAI Kazutomo 国立循環器病研究センター研究所, 生化学部, 特任研究員 (80393213)
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| Project Period (FY) |
2009-05-11 – 2014-03-31
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| Keywords | 内分泌学 / 間葉系細胞由来ホルモン |
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| Research Abstract |
We demonstrated that the BP of CNP ecKO mice is significantly elevated. Their vascular relaxation reaction of mesenteric artery was diminished significantly. We showed that circulating CNP rescues chondrodysplastic CNP ko mice from impaired skeletal growth. We revealed that GC-A protects podocytes from aldosterone-induced glomerular injury.
We demonstrated the insufficiency of postprandial suppression of food-related neural activity by fMRI and satiety feeling in lipodystrophic patients, which was restored by leptin, and that the beneficial effect of leptin /amylin coadministration on glucose and lipid metabolism in DIO mice. Owing to our investigator-initiated trial, marketing and manufacturing of recombinant human leptin for lipodystrophy were approved in 2013 in Japan. We demonstrated on adipogenic potential of human iPS/ES cells in vitro, and that these adipocytes can survive for at least 4 weeks after transplantation.
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[Journal Article] Complexity of molecular forms of B-type natriuretic peptide in heart failure2013
Author(s)
Nishikimi, T., Kuwahara, K., Nakagawa, Y., Kangawa, K., Minamino, N., Nakao, K
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Journal Title
Heart
Volume: 99(10)
Pages: 677-679
Peer Reviewed
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[Patent(Industrial Property Rights)] Method of examining polycystic kidney disease and method of screening for therapeutic agent of the disease2011
Inventor(s)
長船健二, 塩田文彦, 豊田太郎, 中尾一和, 曽根正勝, 田浦大輔
Industrial Property Rights Holder
長船健二, 塩田文彦, 豊田太郎, 中尾一和, 曽根正勝, 田浦大輔
Industrial Property Rights Type
PCT
Industrial Property Number
PCT/JP2011/006203
Filing Date
2011-11-07
Overseas
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