2012 Fiscal Year Final Research Report
Elucidating mechanisms of embryonic cerebellar development
| Project/Area Number |
21240027
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Nagoya University |
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Principal Investigator |
MIYATA Takaki 名古屋大学, 医学系研究科, 教授 (70311751)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Ayano 名古屋大学, 大学院・医学系研究科, 准教授 (90360528)
SAKAKIBARA Akira 名古屋大学, 大学院・医学系研究科, 助教 (20510217)
HASHIMOTO Mitsuhiro 名古屋大学, 大学院・医学系研究科, 特任助教 (90311357)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 発生 / 発達 / 再生神経科学 |
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| Research Abstract |
This study aimed at elucidating mechanisms of cerebellar development. Special attentions were paid on the behavior of young Purkinje cells and their progenitor cells. Understanding of how Purkinje cells migrate and form a layer in the cerebellar cortex is important for dissecting pathogenesis of human cerebellar malformations. We visualized newly-generated Purkinje cells’ morphology and dynamics for the first time and the results were published. Cell cycle parameters and lineage of progenitor cells that give rise to Purkinje cells were also studied.
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