2012 Fiscal Year Final Research Report
Basal ganglia outputs to the thalamus and cortex
| Project/Area Number |
21240039
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
NAMBU Atsushi 生理学研究所, 統合生理研究系, 教授 (80180553)
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| Co-Investigator(Kenkyū-buntansha) |
NAMBU Minoru 玉川大学, 脳科学研究所, 教授 (40118451)
KAWAGUCHI Yasuo 生理学研究所, 大脳皮質機能研究系, 教授 (40169694)
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| Co-Investigator(Renkei-kenkyūsha) |
HATANAKA Nobuhiko 生理学研究所, 統合生理研究系, 助教 (80296053)
CHIKEN Satomi 生理学研究所, 統合生理研究系, 助教 (30396262)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 大脳基底核 / 視床 / 大脳皮質 / 運動野 / 随意運動 / 淡蒼球内節 / 脳深部刺激療法 / 大脳基底核疾患 |
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| Research Abstract |
We have investigated how the outputs from the basal ganglia contribute to the activity in the thalamus and motor cortices, and their relations to the movement disorders and their therapy. Basal ganglia outputs inhibit thalamic activity. However, repetitive pallidal stimulation sometimes induced excitation in the thalamus and cortex. The mechanism of deep brain stimulation targeting the globus pallidus was considered to be the interruption of abnormal information flow from the basal ganglia to the thalamus.
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[Presentation] What electrophysiology teaches us about the pathophysiology of dystonia2011
Author(s)
Nambu A, Chiken S, Shashidharan P, Nishibayashi H, Ogura M, Kakishita K, Tanaka S, Tachibana Y, Kita H, Itakura T
Organizer
The International Behavioural and Neural Genetics Society(IBANGS)
Place of Presentation
Rome, Italy
Year and Date
2011-05-12
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