2011 Fiscal Year Final Research Report
Analysis of dynamic structure-function network of heterochromatin
| Project/Area Number |
21247001
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Hokkaido University |
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Principal Investigator |
MURAKAMI Yota 北海道大学, 大学院・理学研究院, 教授 (20260622)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Katsunori 関西学院大学, 理工学部, 教授 (60273926)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ヘテロクロマチン / RNAi |
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| Research Abstract |
Heterochromatin is an important for epigenetic gene regulation and maintenance of genetic information. Using fission yeast as a model organism, we focused on RNAi-directed heterochromatin formation and tried to understand the molecular mechanism of its formation and function. We revealed a part of network of transcription factors that regulate the formation and function of heterochromatin. In addition, we also presented a novel concept : factory for RNAi-directed heterochromatin formation is formed at nuclear periphery.
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