2011 Fiscal Year Final Research Report
Study of induction mechanisms of autophagy in innate immunity
| Project/Area Number |
21249004
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 自然免疫 / オートファジー / ショウジョウバエ / 抗菌ペプチド / PGRP |
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| Research Abstract |
PGRP-LE, a pathogen sensor in Drosophila, induces autophagy after recognition of bacteria such as Listeria in the cytoplasm. A Drosophila homologue of p62 (SQSTM1)encoding by Ref(2)P was identified as a down-stream regulator showing direct binding to PGRP-LE, that is crucial for PGRP-LE-dependent induction of autophagy and host survival after Listerial infection. Moreover, a functional domain of PGRP-LE required for autophagy induction was identified.
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Research Products
(9 results)
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[Journal Article] Cooperative regulation of the induction of the novel antibacterial listericin by PGRP-LE and the JAK-STAT pathway2010
Author(s)
Goto, A., Yano, T., Terashima, J., Iwashita, S., Oshima, Y. and Kurata, S.
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 15731-15738
Peer Reviewed
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