2013 Fiscal Year Final Research Report
Molecular characterization of volume-activated anion channels and elucidation of cell death-survival switching mechanisms
| Project/Area Number |
21249010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Toshiaki 生理学研究所, 細胞器官研究系, 特任准教授 (00373283)
SHIMIZU Takahiro 富山大学, 大学院医学薬学研究部, 准教授 (40353437)
ONO Koh 京都大学, 医学研究科, 講師 (00359275)
AKATSUKA Yuhko 鈴鹿医療科学大学, 薬学部, 准教授 (90321611)
NUMATA Tomohiro 京都大学, 工学研究科, 助教 (20455223)
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| Co-Investigator(Renkei-kenkyūsha) |
KOIZUMI Amane 生理学研究所, 細胞器官研究系, 准教授 (10296551)
KUKITA Fumio 生理学研究所, 細胞器官研究系, 助教 (40113427)
URAMOTO Hiromi 生理学研究所, 細胞器官研究系, 特別協力研究員 (50390696)
AKITA Tenpei 生理学研究所, 細胞器官研究系, 特任助教 (00522202)
SATO Kaori 生理学研究所, 細胞器官研究系, 特別協力研究員 (60614196)
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| Project Period (FY) |
2009-04-01 – 2013-03-31
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| Keywords | 容積感受性アニオンチャネル / マキシアニオンチャネル / 酸感受性アニオンチャネル / 細胞容積調節 / アポトーシス / ネクローシス / 虚血性細胞死 / ATP放出 |
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| Research Abstract |
In the present study, several types of anion channels, which are involved in cell death-survival switching, were investigated, and the followings were elucidated: 1. Reactive oxygen species (ROS) or dissociation of ABCF2 and protein tyrosine dephosporylation are involved in activation of VSOR and Maxi-Cl, respectively. 2. Three and two candidates were selected as the candidate molecules for VSOR and Maxi-Cl, respectively. 3. Rescue from apoptotic, necrotic and ischemic cell death is induced by regulating the activities of VSOR, ASOR and CFTR anion channels.
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