2012 Fiscal Year Final Research Report
Measles pathogenesis as studied using animal models
| Project/Area Number |
21249032
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
YANAGI Yusuke 九州大学, 医学研究院, 教授 (40182365)
|
|---|
| Project Period (FY) |
2009 – 2012
|
| Keywords | 麻疹ウイルス / 動物モデル / 受容体 / インターフェロン / 膜融合 |
|---|
| Research Abstract |
SLAM knockin mice well reproduced immunological abnormalities observed in human measles. However, measles virus only grew in type I interferon receptor knockout mice, since it could not effectively counteract type I interferons in mouse cells. To overcome this problem, transgenic mice were established in which type I interferons are suppressed in measles virus-infected cells. Furthermore, it was demonstrated using 10-day-old suckling hamsters that enhanced fusion activity of the measles virus fusionprotein plays an important role in measles virus spread in neuronal cells that lack efficient receptors.
|
