2013 Fiscal Year Final Research Report
Development of glyco-biomarkers for predicting life-style related diseases
| Project/Area Number |
21249038
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
EIJI MIYOSHI 大阪大学, 医学(系)研究科(研究院), 教授 (20322183)
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| Co-Investigator(Kenkyū-buntansha) |
宝学 英隆 奈良先端科学技術大学院大学, 保健管理センター, 教授 (50314323)
中村 祐 香川大学, 医学部, 教授 (70291440)
新崎 信一郎 大阪大学, 医学系研究科, 助教 (60546860)
鎌田 佳宏 大阪大学, 医学系研究科, 助教 (30622609)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 糖鎖 / 生活習慣病 / 予防マーカー / レクチン / IgG / 脂肪肝 / 皮膚 |
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| Research Abstract |
Oligosaccharide is one of the most important post-translational modifications of proteins. The oligosaccharide structure is changed in carcinogenesis, differentiation and proliferation. In the present study, we have developed novel glycol-markers for predicting life-style related diseases, using glycol-proteomic analyses. We collected serum samples and clinical information of people who got medical check. We developed a glycol marker, which can distinguish high/low risk people for life-style related diseases in future. We also developed a lectin-antibody ELISA kit for determining agalactosyl IgG, which represents the status of chronic inflammation diseases. Oligosaccharide remodeling mice showed us a pathophysiological signification of aberrant glycosylation involved in life-style related diseases.
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