2012 Fiscal Year Final Research Report
Magnetic stem/progenitor cell targeting for tissue regeneration through the angiogenesis
| Project/Area Number |
21249079
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
OCHI Mitsuo 広島大学, 大学院・医歯薬保健学研究院, 教授 (70177244)
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| Co-Investigator(Kenkyū-buntansha) |
YASUNAGA Yuji 広島大学, 大学院・医歯薬保健学研究院, 寄附講座教授 (40253075)
ASAHARA Takayuki 東海大学, 医学部, 教授 (20246200)
ADACHI Nobuo 広島大学, 病院, 准教授 (30294383)
KAMEI Naosuke 広島大学, 病院, 病院助教 (70444685)
NAKASA Tomoyuki 広島大学, 病院, 病院助教 (60467769)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAHARA Hiroshi 東京医科歯科大学, 大学院・医歯薬学総合研究科, 教授 (70294460)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 移植・再生医療 / 再生医学 / 細胞・組織 |
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| Research Abstract |
We performed the basic research about tissue regeneration using magnetic targeting of bone marrow mesenchymal stem cells or endothelial progenitor cells in muscloskeletal and spinal cord injury models. Magnetic cell targeting enhanced the effect of cell transplantation on the tissue repair in all injury models. We suspected that magnetic cell targeting contributed the tissue repair by promoting accumulation, adhesion and proliferation of transplanted cells.
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