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2012 Fiscal Year Final Research Report

Longitudinal study for neuro-degenerative diseases in Papua, Indonesia

Research Project

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Project/Area Number 21256005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Neurology
Research InstitutionResearch Institute for Humanity and Nature

Principal Investigator

OKUMIYA Kiyohito  総合地球環境学研究所, 研究部, 准教授 (20253346)

Co-Investigator(Kenkyū-buntansha) MATSUBAYASHI Kozo  京都大学, 東南アジア研究所, 教授 (70190494)
KUZUHARA Shigeki  鈴鹿医療科学大学, 保健衛生学部医療福祉学科, 教授 (70111383)
KOKUBO Yasumasa  三重大学, 医学(系)医学科(研究院), 講師 (60263000)
WADA Taizo  京都大学, 東南アジア研究所, 特任准教授 (90378646)
SAZ E Garcia Del  高知大学, 人文社会科学部門, 助教 (20294829)
SEGUCHI Harumichi  神戸女子大学, 健康福祉学部, 教授 (90030866)
TOMIMOTO Hidekazu  三重大学, 医学(系)医学科(研究院), 教授 (80324648)
OSAKI Yasushi  高知大学, 医歯学系, 助教 (20294829)
YAMAUCHI Taro  北海道大学, 医学部保健科学研究院, 准教授 (70345049)
Co-Investigator(Renkei-kenkyūsha) ONISHI Hideyuki  同志社女子大学, 現代社会学部, 准教授 (60414033)
Project Period (FY) 2009 – 2012
Keywords神経変性疾 / パーキンソン症候 / 運動ニューロン疾患
Research Abstract

We diagnosed 64 cases of neurological diseases consisting of 1) ALS; 17 cases of probable and definite ALS, 10 cases of possible ALS, including three cases with cognitive impairment (CI), 2) 13 cases of ALS and/or parkinsonism including five cases with CI, 3) 19 cases of parkinsonism including one case with CI, 4) 2 cases of poliomyeloradiculitis, 5)one case of Dopa responsive dystonia.

  • Research Products

    (63 results)

All 2013 2012 2011 2010 2009

All Journal Article (41 results) (of which Peer Reviewed: 22 results) Presentation (15 results) Book (7 results)

  • [Journal Article] 西ニューギニアの神経難病多発地域を歩く-第2報-辺境のジャングル・共同体・現代医学-2013

    • Author(s)
      平田温、奥宮清人、松林公蔵、稲村哲也、M.B.インドラジャヤ、葛原茂樹、石本恭子、木村友美、今井必生、陳蚊玲、瀬口春道、エヴァ・ガルシア・デル・サス、藤澤道子
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 217-227

    • Peer Reviewed
  • [Journal Article] インドネシア・パプア州低地バデにおける暮らしと文化-文化人類学と医療調査の連携を探る予備的研究-2013

    • Author(s)
      稲村哲也、木村友美、石本恭子、奥宮清人、平田温、松林公蔵、今井必生、陳蚊玲、葛原茂樹、瀬口春道、エヴァ・ガルシア、藤澤道子.
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 228-241

    • Peer Reviewed
  • [Journal Article] 開発途上地域における糖尿病にみる健康教育の重要性-インドネシア・パプア州での症例より-2013

    • Author(s)
      木村友美、石本恭子、稲村哲也、陳政玲、今井必生、平田温、葛原茂樹、瀬口春道、エヴァ・ガルシア、藤澤道子、松林公蔵、奥宮清人
    • Journal Title

      ヒマラヤ学誌

      Volume: 14 Pages: 211-216

    • Peer Reviewed
  • [Journal Article] Long-term care prevention project in Japan2013

    • Author(s)
      Fukutomi E, Kimura Y, Wada T, Okumiya K, Nlatsubayashi K.
    • Journal Title

      Lancet

      Volume: 12 Pages: 381

  • [Journal Article] VPS35 mutation in Japanese patients with typical Parkinson' s disease2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Mov Disord

      Volume: 27(11) Pages: 1413-7

    • DOI

      doi: 10. 1002/mds. 25145.

  • [Journal Article] Correlation of systolic blood pressure with age and body mass index in native Papuan populations2012

    • Author(s)
      Fujisawa M, Okumiya K
    • Journal Title

      Hypertens Res.

      Volume: 35(9) Pages: 959-60

    • DOI

      D01:10.1038/hr.2012.106. Epub 2012 Jul 12

    • Peer Reviewed
  • [Journal Article] α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      J Neuropathol Exp Neurol.

      Volume: 71(7) Pages: 625-30

    • Peer Reviewed
  • [Journal Article] VPS35 mutation in Japanese patients with typical Parkinson' s disease.2012

    • Author(s)
      Kokubo Y, Kuzuhara S,
    • Journal Title

      Mov Disord

      Volume: 27(11) Pages: 1413-7

    • Peer Reviewed
  • [Journal Article] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

    • Peer Reviewed
  • [Journal Article] Mutational analysis of familial and sporadic amyotrophic lateral sclerosis with OPTN mutations in Japanese population2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Amyotroph Lateral Scler

      Volume: 13(6) Pages: 562-6

    • Peer Reviewed
  • [Journal Article] C90RF72 Repeat Expansion in Amyotrophic Lateral Sclerosis in the Kii Peninsula of Japan2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Arch Neurol

      Volume: 69(9) Pages: 1154-8

    • Peer Reviewed
  • [Journal Article] An increase in ALS incidence on the Kii Peninsula, 1960-2009: a possible link to change in drinking water source2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Amyotroph Lateral Scler

      Volume: 13(4) Pages: 347-50

    • Peer Reviewed
  • [Journal Article] ALS-parkinsonism-dementia complex of Kii and other related diseases in Japan2012

    • Author(s)
      Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

      Volume: Suppl 1 Pages: S190-1

  • [Journal Article] Cardiac ^<123>I-meta-iodobenzylguanidine scintigraphy in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula, Japan2012

    • Author(s)
      Kokubo Y, Nomura Y, Morimoto S, Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 18 Pages: 306-8

    • DOI

      doi: 10. 1016/ j. parkreldis. 2011. 08. 005.

    • Peer Reviewed
  • [Journal Article] <123>~I-meta-iodobenzylguanidine scintigraphy in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula, Japan2012

    • Author(s)
      Kokubo Y, Nomura Y, Morimoto S, Kuzuhara S
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 18 Pages: 306-8

    • DOI

      10.1016/j.parkreldis.2011.08.005

    • Peer Reviewed
  • [Journal Article] PLA2G6 variant in Parkinson' s disease2011

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      J Hum Genet

      Volume: 56 (5) Pages: 401-3

    • DOI

      doi : 10. 1038/ jhg. 2011. 22. 455-460

  • [Journal Article] Prevalence of Parkinson' s disease and atypical parkinsonian syndromes in a rural Japanese district2011

    • Author(s)
      0saki Y, Morita Y, Kuwahara T, Miyano I, Doi Y
    • Journal Title

      Acta Neurol Scand

      Volume: 124 (3) Pages: 182-7

    • DOI

      doi: 10. 1111/ j. 1600-0404. 2010. 01442. x.

  • [Journal Article]2011

    • Author(s)
      Yata K, Oikawa S, Sasaki R, Shindo A, Yang R, Murata M, Kanamaru K, Tomimoto H.
    • Journal Title

      Brain Res

      Volume: 1410 Pages: 12-23

    • DOI

      doi: 10. 1016/ j. brainres. 2011. 06. 064.

  • [Journal Article] Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice2011

    • Author(s)
      Tomimoto H
    • Journal Title

      Stroke

      Volume: 42(4) Pages: 1122-8

    • DOI

      doi10.1161/STROKEAHA.110.603399.

  • [Journal Article] グアムと紀伊半島にみられるparkinsonism-ALS-dementia複合2011

    • Author(s)
      葛原茂樹
    • Journal Title

      日本臨牀(増刊号10認知症学下)

      Volume: 69 Pages: 455-460

  • [Journal Article] 血管性パーキンソニズム2011

    • Author(s)
      葛原茂樹
    • Journal Title

      日本臨牀(増刊号10認知症学下)

      Volume: 69 Pages: 335-338

  • [Journal Article] 牟婁病-紀伊ALS・パーキンソン・認知症複合(特集:続・日本人の発見した神経疾患)2011

    • Author(s)
      葛原茂樹
    • Journal Title

      Brain Nerve

      Volume: 63(2) Pages: 119-129

  • [Journal Article] Controversyパーキンソン病の薬物治療はできるだけ早く始める方がよい2011

    • Author(s)
      大崎康史
    • Journal Title

      NO.MDSJ Letters

      Volume: 4 Pages: 1-3

  • [Journal Article] パーキンソン病患者のQOLと予後2011

    • Author(s)
      大崎康史
    • Journal Title

      CLINICAL NEURO SCIENCE

      Volume: 29 Pages: 514-515

  • [Journal Article] No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in .Tapanese patients2010

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Neurosci Lett

  • [Journal Article] Higher-dose glutathione therapy for Parkinson' s disease in Japan: is it really safe?2010

    • Author(s)
      Naito Y, Matsuo K, Kokubo Y, Narita Y, Tomimoto H
    • Journal Title

      Mov Disord.

      Volume: 25(7) Pages: author reply 962-3

    • DOI

      doi: 10. 1002/mds. 23022.

  • [Journal Article] Changes in the incidence and clinical features of ALS in the Koza, Kozagawa, and Kushimoto area of the Kii Peninsula--from the 1960s to the 2000s (follow-up study).2010

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Brain Nerve

      Volume: 62(1) Pages: 72-80

  • [Journal Article] No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients2010

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Journal Title

      Neurosci Lett

    • Peer Reviewed
  • [Journal Article] Painful neck on rotation: diagnostic significance for crowned dens syndrome2010

    • Author(s)
      Kuzuhara S
    • Journal Title

      J Neurol

      Volume: 257(1) Pages: 132-5

    • Peer Reviewed
  • [Journal Article] 17th Symposium on the Treatment of Parkinson' s Disease. September 27, 2008, Tokyo. Foreword2009

    • Author(s)
      Kuzuhara S, Takahashi R
    • Journal Title

      J Neurol

      Volume: 256 Suppl 3 Pages: 269

    • Peer Reviewed
  • [Journal Article] Juvenile muscular atrophy of the distal upper extremity (hirayama disease) in two lanky look-alike brothers2009

    • Author(s)
      Kajikawa H, Kokubo Y, Taniguchi A, Naito Y, Kuzuhara S
    • Journal Title

      Neurologist

      Volume: 15 (4) Pages: 220-2

    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Satoh M, Takeda K, Kuzuhara S. Agraphia in intellectually normal Japanese patients with ALS: omission of kana letters
    • Journal Title

      J Neurol

      Volume: 256(9) Pages: 1455-60

    • Peer Reviewed
  • [Journal Article] Neuro-Sweet disease:report of the first autopsy case.2009

    • Author(s)
      Kokubo Y
    • Journal Title

      BMJ Case Rep

      Volume: pii Pages: bcrO7

    • Peer Reviewed
  • [Journal Article] Anti-N-methyl‐D‐aspartate receptor-related grave but reversible encephalitis with ovarian teratoma in 2 Japanese women presenting with excellent recovery without tumor resection2009

    • Author(s)
      Kokubo Y
    • Journal Title

      Eur Neurol

      Volume: 61 Pages: 50-1

    • Peer Reviewed
  • [Journal Article] Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula2009

    • Author(s)
      Morimoto S, Kuzuhara S, Kokubo Y
    • Journal Title

      Japan. Mov Disord

      Volume: 24(l) Pages: 123-6

    • Peer Reviewed
  • [Journal Article] Research Committee on the Neurodegenerative Diseases of Japan. Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis2009

    • Author(s)
      Kuzuhara S
    • Journal Title

      J Neurol Sci

      Volume: 15;276(1-2) Pages: 163-9

    • Peer Reviewed
  • [Journal Article] Cross sectional and longitudinal studies of three-dimensional stereotactic surface projection SPECT analysis in Parkinson' s disease2009

    • Author(s)
      0saki Y, Morita Y, Fukumoto M, Akagi N, Yoshida S, Doi Y
    • Journal Title

      Mov Disord

      Volume: 24(10) Pages: 1475-80

    • DOI

      doi: 10.1002/mds.22623.o

    • Peer Reviewed
  • [Journal Article] パーキンソン病初期治療における薬剤選択2009

    • Author(s)
      大崎康史
    • Journal Title

      Medico

      Volume: 40 Pages: 9-11

  • [Journal Article] 紀伊半島・グアム・ニューギニアのALS/パーキンソン・認知症複合2009

    • Author(s)
      葛原茂樹
    • Journal Title

      神経心理学

      Volume: 48 Pages: 625-633

  • [Journal Article] パーキンソン病をめぐる最近の話題と治療の進歩2009

    • Author(s)
      葛原茂樹
    • Journal Title

      日本内科学会雑誌

      Volume: 98 Pages: 57-66

  • [Journal Article] 目で見るパーキンソン病診療の進歩2009

    • Author(s)
      葛原茂樹
    • Journal Title

      日本医事新報

      Volume: 4460 Pages: 65-68

  • [Presentation] Neutron activation analysis of trace elements in scalp hair from ALS patients and residents of the Kii Peninsula, Japan2012

    • Author(s)
      Kihira T, Kokubo Y
    • Organizer
      23RD INTERNATIONAL SYMPOSIUM ON ALS/MND
    • Place of Presentation
      Chicago, USA
    • Year and Date
      20121205-07
  • [Presentation] No association between ATXN2 (SCA2) CAG repeat expansion and amyotrophic lateral sclerosis /parkinsonism-dementia complex of the Kii peninsula, Japan2012

    • Author(s)
      Tomiyama H, Kokubo Y
    • Organizer
      ASHG (American Society of Human Genetics) annual meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-11-06
  • [Presentation] The Asp620Asn mutation of VPS35 in Japanese patients with typical Parkinson disease.2012

    • Author(s)
      Ando M, Kokubo Y
    • Organizer
      ASHG (American Society of Human Genetics) annual meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-11-06
  • [Presentation] VPS35 Asp620Asn mutation in Japanese patients with Parkinson disease2012

    • Author(s)
      Ando M, Kokubo Y
    • Organizer
      7TH ANNUAL GEO-PD MEETING
    • Place of Presentation
      SEOUL, SOUTH KOREA
    • Year and Date
      2012-10-08
  • [Presentation] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS.2012

    • Author(s)
      Ogaki K, Kokubo Y
    • Organizer
      7TH ANNUAL GEO-PD MEETING
    • Place of Presentation
      SEOUL, SOUTH KOREA
    • Year and Date
      2012-10-08
  • [Presentation] Alfa-Synuclein pathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula, Japan2012

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Organizer
      8th International Conference on Frontotemporal Dementias
    • Place of Presentation
      Manchester, UK
    • Year and Date
      2012-09-05
  • [Presentation] Immunochemical Study Western blotting of tauopathy in ALS/ Parkinson Dementia Complex (PDC), Kii ,Japan2012

    • Author(s)
      Morimoto S, Kokubo Y
    • Organizer
      27th AANP (American Association of Neuropathologists) conference
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-06-24
  • [Presentation] Changing patterns of amyotrophic lateral sclerosis(ALS) and parkinsonism-dementia complex (PDC) of the Kii peninsula in Japan,2012

    • Author(s)
      Kuzuhara S, Kokubo Y
    • Organizer
      13th Asian Oceanian Congress of Neurology,
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2012-06-04
  • [Presentation] Predictors of increase in severity among Japanese amyotrophic lateral sclerosis patients by discriminant analysis2011

    • Author(s)
      Okamoto K, Kuzuhara S, Kokubo Y
    • Organizer
      22th International Symposium on ALS/MND
    • Place of Presentation
      Sydoney, Australia
    • Year and Date
      20111130-1202
  • [Presentation] Neuropsychological study of patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kiipeninsula of Japan2011

    • Author(s)
      SHINDO A, Kuzuhara S, KokuboY
    • Organizer
      22th International Symposium on ALS/MND
    • Place of Presentation
      Sydoney, Australia
    • Year and Date
      20111130-1202
  • [Presentation] Research Consortium of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of the Kii Peninsula of Japan2011

    • Author(s)
      Kokubo Y, Kuzuhara S
    • Organizer
      ICAD 2011
    • Place of Presentation
      Paris, France
    • Year and Date
      20110716-21
  • [Presentation] Parkinson' s disease subtypes based on an epidemiological cohort in a rural Japanese district: a cluster analysis2011

    • Author(s)
      Osaki Y
    • Organizer
      5th International Congress of Parkinson' s Disease & Movement Disorders
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      20110605-09
  • [Presentation] A Biological Marker of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of The Kii Peninsula Of Japan.-Analysis of Cerebrospinal Fluid Phosphorylated Tau2010

    • Author(s)
      Kokubo Y. Kuzuhara S
    • Organizer
      7th International Conference on Frontotemporal Dementias
    • Place of Presentation
      Indianapolis, USA.
    • Year and Date
      20101006-08
  • [Presentation] Amyotrophic lateral sclerosis (ALS)and parkinsoniam-dementia complex (PDC) of the Kii peninsula of Japan. Clinical and neuropathological review2010

    • Author(s)
      Kokubo Y
    • Organizer
      NeuroTalk-2010
    • Place of Presentation
      Singapore EXPO・Singapore
    • Year and Date
      20100626-27
  • [Presentation] Prevalence of Parkinson' s disease and atypical parkinsonian syndromes in a rural Japan2010

    • Author(s)
      Osaki Y
    • Organizer
      14^<th> Congress of the European Federation of Neurological Societies
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2010-09-26
  • [Book] 今日の神経疾患治療指針 第2版2013

    • Author(s)
      大崎康史
    • Total Pages
      873-876
    • Publisher
      西村書店
  • [Book] Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias2012

    • Author(s)
      Kuzuhara S, Kokubo Y
    • Total Pages
      39-54
    • Publisher
      Oxford University Press
  • [Book] 「パーキンソン病」北徹監修健康長寿学大事典-EBMからQOLまで-2012

    • Author(s)
      奥宮清人
    • Total Pages
      319-324.
    • Publisher
      西村書店,
  • [Book] ガイドラインサポートブックパーキンソン病2011

    • Author(s)
      大崎康史
    • Total Pages
      181-195
    • Publisher
      医薬ジャーナル社
  • [Book] 神経科用薬、治療薬マニュアル20112011

    • Author(s)
      葛原茂樹(高久史麿、矢崎義雄監修)
    • Total Pages
      271-385
    • Publisher
      医学書院
  • [Book] 「Q59」『パーキンソン病診療Q&A110』2009

    • Author(s)
      大崎康史
    • Total Pages
      178-179
    • Publisher
      中外医学社
  • [Book] 「パーキンソン認知症複合(グアム島、紀伊半島)」『パーキンソン病基礎・臨床研究のアップデート』2009

    • Author(s)
      小久保康昌
    • Total Pages
      259-263
    • Publisher
      日本臨床

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Published: 2014-08-29  

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