2011 Fiscal Year Final Research Report
The elucidation of the molecular mechanisms of NO-mediated muscle atrophy
| Project/Area Number |
21300149
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
TAKEDA Shin ichi 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 部長 (90171644)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Yuuko 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 室長 (00342931)
IMAMURA Michihiro 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 室長 (80221787)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨格筋 / 筋萎縮 / 一酸化窒素 / 神経型一酸化窒素合成酵素 / 筋肥大 |
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| Research Abstract |
We found that nNOS was involved in not only in the unload-induced muscle atrophy, but also in the overload-induced muscle hypertrophy. nNOS was immediately activated by mechanical overload, and this activation promoted formation of peroxynitrite, a reaction product of nitric oxide with superoxide, which was derived from NADPH oxidase 4(NOX4). These findings may develop therapeutics for muscle atrophy by targeting NO/peroxynitrite.
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[Journal Article] Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle2011
Author(s)
Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Matev MM, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S
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Journal Title
J Cell Sci
Volume: 124(21)
Pages: 3654-3664
DOI
Peer Reviewed
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[Journal Article] Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers2011
Author(s)
F ukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H
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Journal Title
Development
Volume: 138
Pages: 4609-4619
DOI
Peer Reviewed
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[Journal Article] Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle2011
Author(s)
S himizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H
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Journal Title
Cell Metab
Volume: 13
Pages: 170-182
DOI
Peer Reviewed
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[Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading2009
Author(s)
N akao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
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Journal Title
Mol Cell Biol
Volume: 17
Pages: 4798-4811
DOI
Peer Reviewed
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[Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells2009
Author(s)
C hang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada S, Yamamoto H, Motohashi N, Miyagoe-Suzuki Y, Takeda S, Heike T, Nakahata T
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Journal Title
FASEB J
Volume: 23
Pages: 1907-1919
DOI
Peer Reviewed
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