Synthesis of Biomolecule-Responsive Gels and Construction of Intelligent Biomedical Systems

2011 Fiscal Year Final Research Report

• Project/Area Number: 21300182
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kansai University
• Principal Investigator: MIYATA Takashi 関西大学, 化学生命工学部, 教授 (50239414)
• Co-Investigator(Renkei-kenkyūsha): IWASAKI Yasuhiko 関西大学, 化学生命工学部, 教授 (90280990)
• Project Period (FY): 2009 – 2011
• Keywords: インテリジェント材料 / 高分子ゲル / 刺激応答性ゲル / バイオコンジュゲーション

Research Abstract

In this study, biomolecule-responsive gels that underwent changes in the volume in response to a signal biomolecule were prepared as smart biomaterials for constructing novel bio-systems. Furthermore, self-regulated drug delivery systems(DDS), diagnostic sensors and so on were developed using biomolecule-responsive gels. We synthesized biomolecule-crosslinked gels and biomolecule-imprinted gels that swell and shrink in response to a signal biomolecule such as an antigen and a saccharide, and tried to apply their gels to DDS and diagnostic sensors.

Research Products

• [Journal Article] Responsive Behavior of Tumor-Marker-Imprinted Hydrogels Using Macromolecular Cross-linkers (2010)
  • Author(s): T. Miyata, T. Hayashi, Y. Kuriu, T. Uragami
  • Journal Title: J. Mol. Recognit. Volume: 25 Pages: 336-343
  • DOI: DOI:10.1002/jmr.2190
  • Peer Reviewed
• [Journal Article] Controlled Permeation of Model Drugs through a Bioconjugated Membrane with Antigen-Antibody Complexes as Reversible Crosslinks (2010)
  • Author(s): T. Miyata, N. Asami, Y. Okita, T. Uragami
  • Journal Title: Polym. J. Volume: 42 Pages: 834-837
  • DOI: DOI:10.1038/pj.2010.76
  • Peer Reviewed
• [Journal Article] Structural Design of Stimuli-Responsive Bioconjugated Hydrogels That Respond to a Target Antigen (2009)
  • Author(s): T. Miyata, N. Asami, T. Uragami
  • Journal Title: J. Polym. Sci., Polym. Phys. Volume: 47 Pages: 2144-2157
  • Peer Reviewed
• [Journal Article] Synthesis of Glucose-Responsive Bioconjugated Gel Particles Using Surfactant-Free Emulsion Polymerization
  • Author(s): A. Kawamura, Y. Hata, T. Miyata, T. Uragami
  • Journal Title: Colloids Surf. B : Biointerfaces Volume: (in press)
  • DOI: DOI:10.1016/j.colsurfb.2011.10.008
  • Peer Reviewed
• [Presentation] 分子応答性スマートゲルの創成 (2011)
  • Author(s): 宮田隆志
  • Organizer: 第20回ポリマー材料フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2011-11-25
• [Presentation] Bioconjugated Hydrogels That Respond to a Target Biomolecule (2010)
  • Author(s): T. Miyata
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-18
• [Presentation] Responsive Behavior of Biomolecularly Imprinted Hydrogels Having Biomolecules as Ligands (2010)
  • Author(s): T. Miyata
  • Organizer: The 6th International Meeting on Molecular Imprinting(MIP2010)
  • Place of Presentation: New Orleans
  • Year and Date: 2010-08-10
• [Presentation] Smart Hydrogels Exhibiting Biomolecule-Responsive Behavior (2009)
  • Author(s): T. Miyata
  • Organizer: Annual Spring Meeting of Polymer Society of Korea
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 2009-04-10
• [Book] Biomolecule-Responsive Hydrogels, Biomedical Applications of Hydrogels Handbook (2010)
  • Author(s): T. Miyata, M. Ottenbrite, K. Park, T. Okano
  • Total Pages: 65-86
  • Publisher: Springer
• [Book] 生体分子応答性ゲル,食品・化粧品・医療分野へのゲルの利用 (2010)
  • Author(s): 宮田隆志, 西成勝好, 梶原莞爾, 長崎幸夫, 金田勇
  • Total Pages: 168-177
  • Publisher: シーエムシー出版
• [Book] 生体分子応答性ゲル(第II部第8章), CSJカレントレビュー01驚異のソフトマテリアル-最新の機能性ゲル研究 (2010)
  • Author(s): 宮田隆志
  • Total Pages: 97-103
  • Publisher: 化学同人
• [Book] スマート3次元高分子ネットワーク-分子応答性ゲル-,超分子サイエンス & テクノロジー-基礎からイノベーションまで- (2009)
  • Author(s): 宮田隆志, 国武豊喜
  • Total Pages: 454-463
  • Publisher: エヌ・ティー・エス出版
• [Remarks] (1)関西大,光で微細模様-樹脂開発,タンパク質転写-低コストの加工,有望,日経産業新聞(2011年7月19日)(10面)
• [Remarks] (2)関大,表面形状自在に変わるフィルムを開発,日刊工業新聞(2011年5月23日)(24面)
• [Patent(Industrial Property Rights)] 複数物質応答性ゲルおよびその製造方法並びにその利用 (2011)
  • Inventor(s): 宮田隆志,浦上忠
  • Industrial Property Rights Holder: 独立行政法人科学技術振興機構,学校法人関西大学
  • Industrial Property Number: 特許権、特願2011-43017
  • Filing Date: 2011-02-28