2011 Fiscal Year Final Research Report
Expression of vasoactive substances in heart failure model of exercise therapy.
| Project/Area Number |
21300198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI Nobuyoshi 東北大学, 大学院・医学系研究科, 助教 (50463790)
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| Co-Investigator(Kenkyū-buntansha) |
KOHZUKI Masahiro 東北大学, 大学院・医学系研究科, 教授 (70234698)
ITO Osamu 東北大学, 大学院・医学系研究科, 准教授 (00361072)
TAKAHASHI Kazuhiro 東北大学, 医学系研究科, 教授 (80241628)
TOTSUNE Kazuhito 東北大学, 薬学研究科, 教授 (80241628)
KANAZAWA Masayuki 東北大学, 医学系研究科, 非常勤講師 (60282050)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リハビリテーション / 運動療法 / 心筋梗塞 / 心不全 |
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| Research Abstract |
Exercise therapy was performed in rats with myocardial infarction. Improvement in echocardiography of left ventricular ejection fraction was observed in the exercise group compared to non-exercise group. Wet lung weight per body weight and plasma BNP level was decreased by exercise therapy. Exercise therapy of heart failure there is also the possibility of improvement of cardiac function has been shown. mRNA expression of (pro)renin receptor, one of the renin-angiotensin-aldosterone system, has been increased is confirmed. The mechanisms of the effectiveness of exercise therapy, was to investigate the influence of (pro)renin receptor.
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[Journal Article] Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure2009
Author(s)
Takuo Hirose, Nobuyoshi Mori, Kazuhito Totsune, Ryo Morimoto, Takahiro Maejima, Takuya Kawamura, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Masahiro Kohzuki, Kazuhiro Takahashi, Yutaka Imai
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Journal Title
Peptides
Volume: 30
Pages: 2316-2322
Peer Reviewed
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