2011 Fiscal Year Final Research Report
Central mechanisms underlying antihypertensive effects of daily exercise in hypertension
| Project/Area Number |
21300253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
WAKI Hidefumi 和歌山県立医科大学, 医学部, 講師 (50274957)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Masanobu 和歌山県立医科大学, 医学部, 教授 (80181593)
KOHSAKA Akira 和歌山県立医科大学, 医学部, 講師 (00458051)
GOURAUD Sabine 和歌山県立医科大学, 医学部, 学内助教 (30453179)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 孤束核 / 高血圧 / 有酸素運動 / 循環調節中枢 / 遺伝子発現 / ヒスタミン / セロトニン |
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| Research Abstract |
Daily exercise has been associated with antihypertensive benefits ; however, its mechanisms remain unclear. To explore this, we have investigated the effects of daily exercise on an important brain area in regulating blood pressure, the nucleus of the solitary tract(NTS), in spontaneously hypertensive rats(SHR). We have revealed that daily exercise alters gene expression profiles and neuronal functions in the NTS of SHR. These results suggest that the plastic changes in the NTS may be involved in the antihypertensive effects of daily exercise. Moreover, we have concluded that the serotoninergic system may have an important role in the functional changes in the NTS induced by daily exercise.
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[Presentation] ラット孤束核の血流阻害は高血圧を惹起する2010
Author(s)
和気秀文, Mohammad ER Bhuiyan, Sabine S Gouraud, 高岸美和, 向阪彰, Julion FR Paton, 前田正信
Organizer
Nuero2010第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会
Place of Presentation
神戸
Year and Date
20100900
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