2011 Fiscal Year Final Research Report
New insulin resistance regulatory factor "susceptibility to fat loading"
| Project/Area Number |
21300255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
KAWAMORI Ryuzo 順天堂大学, 医学研究科, 特任教授 (00116021)
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| Co-Investigator(Kenkyū-buntansha) |
WATADA Hirotaka 順天堂大学, 医学部, 教授 (60343480)
TAMURA Yoshifumi 順天堂大学, 医学部, 准教授 (80420834)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨格筋細胞内脂質 / インスリン抵抗性 / 糖尿病 |
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| Research Abstract |
(Aim) We investigated the effect of high fat diet(HFD) on metabolism in skeletal muscle.(Method) Three days HFD were provided to healthy men after 3 days normal fat diet.(Results) We observed negative correlation between changes in intramyocellular lipid(IMCL) and changes insulin sensitivity(GIR) after HFD. Microarray analysis demonstrated that significant changes of metabolic pathway was observed in high responder group(HR ; increased IMCL and decreased GIR after HFD), but not in low responder group(LR). Gene expression level of fat uptake and oxidation were elevated in HR group.(Conclusion) Our data suggested that gene expression response after HFD in skeletal muscle is associated with IMCL and GIR changes.
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[Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men2011
Author(s)
Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
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Journal Title
Diabetes Invest
Volume: 2
Pages: 310-317
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