2011 Fiscal Year Final Research Report
Cell transformation route and the developmental mechanics which assumed chromosomal aneuploidy an origin
| Project/Area Number |
21310036
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 染色体異数化 / 中心体 / 細胞がん化 / ミトコンドリア機能 / 自然発がん / メロテリック結合 / 長寿命ラジカル / 微小核細胞融合法 |
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| Research Abstract |
It has been believed that the first target of radiation carcinogenesis is DNA. However, this is not proved for radiation carcinogenesis yet. We discovered that frequency of aneuploid cell was closely related to that of radiation-induced cell transformation, but gene mutation was not. Aneuploidy was seen in high frequency in early process of cell transformation. These results strongly suggest that a main target of carcinogenesis by low dose radiation is not DNA, but is centrosome, which are the proteins to constitute chromosomal homeostasis maintenance mechanism.
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Research Products
(30 results)
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[Journal Article] UV B-irradiation enhances the racemization and isomerizationof aspartyl residues and production of N(.)-carboxymethyl lysine(CML) in keratin of skin2011
Author(s)
Mori Y, Aki K, Kuge K, Tajima S, Yamanaka N, Kaji Y, Yamamoto N, Nagai R, Yoshii H, Fujii N, Watanabe M, Kinouchi T, Fujii N.
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Journal Title
J Chromatogr B
Volume: 879(29)
Pages: 3303-3309
Peer Reviewed
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[Journal Article] Usefulness of hexamethylene tetramineas an adjuvant to radiation andcisplatin in the treatment of solidtumorsits independency of p53 status2011
Author(s)
Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Takahashi A, Tanaka H, Suzuki M, Ohnishi K, Kinashi Y, Liu Y, Ohnishi T, Ono K
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Journal Title
J Radiat Res(Tokyo)
Volume: 51(1)
Pages: 27-35
Peer Reviewed
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[Journal Article] FEN1functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells2010
Author(s)
Asagoshi K, Tano K, Chastain PD 2nd, Adachi N, Sonoda E, Kikuchi K, Koyama H, Nagata K, Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J
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Journal Title
Mol Cancer Res
Volume: 8(2)
Pages: 204-215
Peer Reviewed
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[Journal Article] SOD1 Is essential for the viability ofDT40 cells and nuclear SOD1 functions as a guardian of genomic DNA2010
Author(s)
Asagoshi K, Tano K, Chastain PD 2nd, Adachi N, Sonoda E, Kikuchi K, Inoue E, Tano K, Yoshii H, Nakamura J, Tada S, Watanabe M, Seki M, Enomoto T
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Journal Title
JNucleic Acids
Volume: 5
Pages: 795946
Peer Reviewed
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[Journal Article] Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylatedliposomal doxorubicin in vivo, referring to the effect on quiescent cells2009
Author(s)
Masunaga S, Kono K, Nakamura J, Tano K, Yoshida H, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Liu Y, Ono K
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Journal Title
Oncol Rep
Volume: 21(5)
Pages: 1307-1312
Peer Reviewed
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[Journal Article] Induction of DNA double-strand breaks and cellular migration through bystander effects in cells irradiated with the slit-type micro planar beam of the SPring-8 synchrotron2009
Author(s)
Kashino G, Kondoh T, Nariyama N, Umetani K, Ohigashi T, Shinohara K, Kurihara A, Fukumoto M, Tanaka H, Maruhashi A, Suzuki S, Kinashi Y, LiuYong, Masunaga S, Watanabe M, Ono K
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Journal Title
Intern JRadiat Oncol Biol Phys
Volume: 74(1)
Pages: 229-236
Peer Reviewed
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[Presentation] The origin of radiation carcinogenesis is chromosomal aneuploid2010
Author(s)
Watanabe M, Watanabe K, Kashino G, Nawata H, Tano K, Kumagai J, Watanabe M, Watanabe K, Kashino G, Nawata H, Tano K, Kumagai J
Organizer
In a Symposium of European Radiation Reseach Society 2010
Place of Presentation
Stockholm, Sweden.(Invited)
Year and Date
20100905-09
