2012 Fiscal Year Final Research Report
Functional analysis of genes associated with miRNA expression
| Project/Area Number |
21310123
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UI-TEI Kumiko 東京大学, 大学院・理学系研究科, 准教授 (50213327)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHI Kenji 東京大学, 大学院・理学系研究科, 助教 (50466801)
NAITO Yuki ライフサイエンスデータベース統合センター, 特任助教 (60451829)
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| Project Period (FY) |
2009 – 2012
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| Keywords | ゲノム調節 / microRNA |
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| Research Abstract |
In this study, we first developed a high-throughput screening method to identify microRNA (miRNA) which maturation is inhibited at the processing steps, and found several candidate miRNAs. Second, we examined the effects of adenosine deaminases acting on RNAs (ADARs) on miRNA processing, and identified novel 48 editing sites in 24 miRNAs. Each ADAR isoform was considered to inhibit the processing of different miRNAs.
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Research Products
(60 results)
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[Journal Article] IFPA meeting 2012 workshop report I: Comparative placentation and animal models, advanced techniques in placental histopathology, human pluripotent stem cells as a model for trophoblast differentiation2013
Author(s)
Ackerman WE 4th, Carter AM, De Mestre AM, Golos TG, Jeschke U, Kusakabe K, Laurent LC, Parast MM, Roberts RM, Robinson JM, Rutherford J, Soma H, Takizawa T, Ui-Tei K, Las GE.
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Journal Title
Placenta
Volume: vol.34
Pages: S3-5
Peer Reviewed
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